Ameliorative effect of edible Halopteris scoparia against cadmium‐induced reproductive toxicity in male mice: A biochemical and histopathologic study

Andrologia ◽  
2020 ◽  
Vol 52 (6) ◽  
Author(s):  
Özlem Güner ◽  
Adem Güner ◽  
Altuğ Yavaşoğlu ◽  
Nefise Ülkü Karabay Yavaşoğlu ◽  
Oya Kavlak
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Alireza Hosseini ◽  
Mehrdad Shahrani ◽  
Shirin Asgharian ◽  
Maryam Anjomshoa ◽  
Ayoob Rostamzadeh ◽  
...  

Abstract Background Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that is extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of the most important side effects of this drug. It is medically essential to use complementary and alternative drugs. Herbal drugs have long been used as a complementary treatment. Our purpose was to study the effect of hydroalcoholic Allium atroviolaceum L. extract on spermatogenesis in CP-treated mice. Results CP affected a significant decrease in sperm count, motility, viability, and morphology. Sperm count was significantly higher in the all extract groups than in the group of control (p<0.001) and CP group (p<0.001, p<0.01). Sperm motility was significantly greater in the extract (100 and 200mg/kg) groups than in the group of control (p<0.05 and <0.001). Sperm immotility and rotational movement were significantly higher in the CP group than in the CP+extract groups (p<0.001). The sperm viability was significantly greater in the CP+extract (200mg/kg) group than in the CP group (p<0.001). The number of headless sperm, sperm with initial tail, with coiled tail, and sperm with curved body, was significantly lower in the CP+extract (200mg/kg) group than in the CP group (p<0.001). Conclusion A. atroviolaceum extract treatment significantly improved CP-induced reproductive toxicity.


Andrologia ◽  
2021 ◽  
Author(s):  
Marzieh Pirzadeh ◽  
Mohammad Barary ◽  
Seyed Mohammad Hosseini ◽  
Sohrab Kazemi ◽  
Ali Akbar Moghadamnia

Toxicon ◽  
2019 ◽  
Vol 165 ◽  
pp. 13-21 ◽  
Author(s):  
Lucian Del Fabbro ◽  
Cristiano Ricardo Jesse ◽  
Marcelo Gomes de Gomes ◽  
Carlos Borges Filho ◽  
Franciele Donato ◽  
...  

2019 ◽  
Vol 30 (2) ◽  
pp. 100-106 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Chang Kong ◽  
Huimin Chi ◽  
Junxia Li ◽  
Jie Xing ◽  
...  

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Fenju Qin ◽  
Tao Shen ◽  
Jinlin Li ◽  
Junchao Qian ◽  
Jie Zhang ◽  
...  

2007 ◽  
Vol 23 (2) ◽  
pp. 232-238 ◽  
Author(s):  
Amina T. Farag ◽  
Ahmed F. El-Aswad ◽  
Nasra A. Shaaban

2005 ◽  
Vol 17 (4) ◽  
pp. 401 ◽  
Author(s):  
Homa Darmani ◽  
Ahmad S. Al-Hiyasat

The present study evaluated the effect of triethyleneglycol dimethacrylate (TEGDMA) on mouse fertility. Adult male mice were administered TEGDMA (0, 25 and 100 μg kg–1) intragastrically daily for 28 days and then allowed to mate for 10 days with sexually mature untreated female mice; fertility was assessed after a further 10 days. Females mated by males that had been treated with TEGDMA had a significant reduction in pregnancy rate, as well as a significant increase in the total number of resorptions as a percentage of the total number of implantations. Furthermore, the number of animals in which resorption occcurred was increased significantly. Males treated with TEGDMA exhibited a significant reduction in bodyweight, testis weight and the weight of the seminal vesicles and preputial glands. Testicular and epididymal sperm counts, as well as the efficiency of sperm production, were also significantly reduced in TEGDMA-treated males. The results suggest that TEGDMA has adverse effects on the fertility and reproductive system of male mice.


2015 ◽  
Vol 31 (10) ◽  
pp. 1250-1263 ◽  
Author(s):  
Milindmitra Lonare ◽  
Manoj Kumar ◽  
Sachin Raut ◽  
Amar More ◽  
Sagar Doltade ◽  
...  

2016 ◽  
Vol 32 (9) ◽  
pp. 1598-1606 ◽  
Author(s):  
Hong-wei Wang ◽  
Bian-hua Zhou ◽  
Sen Zhang ◽  
Hong-wei Guo ◽  
Ji-liang Zhang ◽  
...  

2018 ◽  
Vol 7 (4) ◽  
pp. 259-266
Author(s):  
Ali Soleimanzadeh ◽  
Mahdieh Pourebrahim ◽  
Nowruz Delirezh ◽  
Mehdi Kian

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