Evaluation of ameliorative effect of curcumin on imidacloprid-induced male reproductive toxicity in wistar rats

2015 ◽  
Vol 31 (10) ◽  
pp. 1250-1263 ◽  
Author(s):  
Milindmitra Lonare ◽  
Manoj Kumar ◽  
Sachin Raut ◽  
Amar More ◽  
Sagar Doltade ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Ameliorative Effect

scholarly journals Ameliorative effect of Allium atroviolaceum on sperm quality in cyclophosphamide-treated mice

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Alireza Hosseini ◽  
Mehrdad Shahrani ◽  
Shirin Asgharian ◽  
Maryam Anjomshoa ◽  
Ayoob Rostamzadeh ◽  
...  
Keyword(s):  
Side Effects ◽  
Alkylating Agent ◽  
Sperm Quality ◽  
Sperm Count ◽  
Reproductive Toxicity ◽  
Herbal Drugs ◽  
Sperm Viability ◽  
Complementary Treatment ◽  
Ameliorative Effect ◽  
Alternative Drugs

Abstract Background Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that is extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of the most important side effects of this drug. It is medically essential to use complementary and alternative drugs. Herbal drugs have long been used as a complementary treatment. Our purpose was to study the effect of hydroalcoholic Allium atroviolaceum L. extract on spermatogenesis in CP-treated mice. Results CP affected a significant decrease in sperm count, motility, viability, and morphology. Sperm count was significantly higher in the all extract groups than in the group of control (p<0.001) and CP group (p<0.001, p<0.01). Sperm motility was significantly greater in the extract (100 and 200mg/kg) groups than in the group of control (p<0.05 and <0.001). Sperm immotility and rotational movement were significantly higher in the CP group than in the CP+extract groups (p<0.001). The sperm viability was significantly greater in the CP+extract (200mg/kg) group than in the CP group (p<0.001). The number of headless sperm, sperm with initial tail, with coiled tail, and sperm with curved body, was significantly lower in the CP+extract (200mg/kg) group than in the CP group (p<0.001). Conclusion A. atroviolaceum extract treatment significantly improved CP-induced reproductive toxicity.

Cocos nucifera L. oil alleviates lead acetate-induced reproductive toxicity in sexually-matured male Wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Olugbemi T. Olaniyan ◽  
Olakunle A. Ojewale ◽  
Ayobami Dare ◽  
Olufemi Adebayo ◽  
Joseph E. Enyojo ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Histological Analysis ◽  
Cocos Nucifera ◽  
Reproductive Toxicity ◽  
Positive Control ◽  
Negative Control ◽  
Male Wistar Rats ◽  
Cocos Nucifera L

Abstract Objectives Lead primarily affects male reproductive functions via hormonal imbalance and morphological damage to the testicular tissue with significant alteration in sperm profile and oxidative markers. Though, different studies have reported that Cocos nucifera L. oil has a wide range of biological effects, this study aimed at investigating the effect of Cocos nucifera L. oil on lead acetate-induced reproductive toxicity in male Wistar rats. Methods Twenty (20) sexually matured male Wistar rats (55–65 days) were randomly distributed into four groups (n=5). Group I (negative control)—distilled water orally for 56 days, Group II (positive control)—5 mg/kg bwt lead acetate intraperitoneally (i.p.) for 14 days, Group III—6.7 mL/kg bwt Cocos nucifera L. oil orally for 56 days and Group IV—lead acetate intraperitoneally (i.p.) for 14 days and Cocos nucifera L. oil for orally for 56 days. Rats were sacrificed by diethyl ether, after which the serum, testis and epididymis were collected and used for semen analysis, biochemical and histological analysis. Results The lead acetate significantly increases (p<0.05) testicular and epididymal malondialdehyde (MDA) levels, while a significant reduction (p<0.05) in sperm parameters, organ weight, testosterone and luteinizing hormone was observed when compared with the negative control. The coadministration of Cocos nucifera oil with lead acetate significantly increases (p<0.05) testosterone, luteinizing hormone, sperm parameters and organ weight, with a significant decrease (p<0.05) in MDA levels compared with positive control. Histological analysis showed that lead acetate distorts testicular cytoarchitecture and germ cell integrity while this was normalized in the cotreated group. Conclusions Cocos nucifera oil attenuates the deleterious effects of lead acetate in male Wistar rats, which could be attributed to its polyphenol content and antioxidant properties.

Ameliorative effect of Alpinia officinarum Hance extract on nonylphenol‐induced reproductive toxicity in male rats

Andrologia ◽  
2021 ◽  
Author(s):  
Marzieh Pirzadeh ◽  
Mohammad Barary ◽  
Seyed Mohammad Hosseini ◽  
Sohrab Kazemi ◽  
Ali Akbar Moghadamnia
Keyword(s):  
Reproductive Toxicity ◽  
Male Rats ◽  
Alpinia Officinarum ◽  
Ameliorative Effect

Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum (Asteraceae) in male Wistar rats

2019 ◽  
Vol 17 (5) ◽  
pp. 366-373 ◽  
Author(s):  
Pierre Watcho ◽  
Ismaelle Rosine Mpeck ◽  
Patrick Brice Deeh Defo ◽  
Modeste Wankeu-Nya ◽  
Esther Ngadjui ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Beneficial Effects ◽  
Male Wistar Rats

scholarly journals Lead aggravates the diabetic-induced reproductive toxicity in male Wistar rats

2016 ◽  
Vol 5 (5) ◽  
pp. 1465-1476 ◽  
Author(s):  
K. Pratap Reddy ◽  
Madamsetti Narayana Rao ◽  
J. S. R. Murthy ◽  
P. Sreenivasula Reddy
Keyword(s):  
Metabolic Disorder ◽  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Lead Contamination ◽  
Contemporary Society ◽  
Male Wistar Rats

Diabetes, an unresolved metabolic disorder, and lead contamination are prevalent problems in contemporary society.

Ameliorative effect of vitamin C on the haematological changes induced by exposure of chlorpyriphos and lead acetate in Wistar rats

2013 ◽  
Vol 23 (4) ◽  
pp. 829-834
Author(s):  
Nisar Ahmad Nisar ◽  
Mudasir Sultana ◽  
Naseer Ahmad Baba ◽  
Parveez Ahmad Para ◽  
Hina Ashraf Waiz ◽  
...  
Keyword(s):  
Vitamin C ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Ameliorative Effect ◽  
Haematological Changes
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