LY294002, a PI3K pathway inhibitor, prevents leptin-induced adverse effects on spermatozoa in Sprague-Dawley rats

Andrologia ◽  
2018 ◽  
Vol 51 (3) ◽  
pp. e13196 ◽  
Author(s):  
Amir Hafidz Md Mokhtar ◽  
Ifrah Alam Malik ◽  
Noor Azean Anis Abd Aziz ◽  
Fayez A. Almabhouh ◽  
Damayanthi Durairajanayagam ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Pi3k Pathway ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Effect of Gasohol on The Rat Liver

1997 ◽  
Vol 3 (S2) ◽  
pp. 49-50
Author(s):  
B.A. MacDuff ◽  
A. Singh ◽  
I. Chu
Keyword(s):  
United States ◽  
Body Weight ◽  
Adverse Effects ◽  
Rat Liver ◽  
Corn Oil ◽  
The United States ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Although there are a variety of gasoline ethanol mixtures proposed as neat fuels (ethanol 85% + gasoline 15% = E85; E95) for automobiles, gasohol (gasoline 90% + ethanol 10%) is presently used as a fuel in the United States. The adverse effects, if any, of gasohol ingestion are unknown; effects on the liver of rats administered gasohol are examined in this study.Twenty-four female Sprague-Dawley rats received daily, via gavage, one of the three concentrations of gasohol for 28 days; LD50/20, LD50/100 and LD50/1000, where LD50 = 1.5g ethanol / kg body weight (bw) and 14g gasoline / kg bw. The LD50 was based on that of gasoline, which was obtained from literature value.1 The amount of ethanol added to stock gasohol was only 1/10 its LD50, required to maintain the gasoline ethanol proportion of 9:1. Gasohol was administered in corn oil with total volume 10 ml. Animals that received only corn oil served as controls.

Absence of adverse effects following the gavage administration of methyl propyl trisulfide to Sprague-Dawley rats for 90 days

2018 ◽  
Vol 120 ◽  
pp. 544-551
Author(s):  
Maria Bastaki ◽  
Michel Aubanel ◽  
Thierry Cachet ◽  
Jan Demyttenaere ◽  
Maodo Malick Diop ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Adverse effects of noise stress on glucose homeostasis and insulin resistance in Sprague-Dawley rats

Heliyon ◽  
2019 ◽  
Vol 5 (12) ◽  
pp. e03004 ◽  
Author(s):  
Ayodele Olufemi Morakinyo ◽  
Titilola Aderonke Samuel ◽  
Funmileyi Olubajo Awobajo ◽  
Daniel Abiodun Adekunbi ◽  
Idowu Olufemi Olatunji ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adverse Effects ◽  
Glucose Homeostasis ◽  
Sprague Dawley ◽  
Noise Stress ◽  
Sprague Dawley Rats

Absence of adverse effects following administration of piperine in the diet of Sprague-Dawley rats for 90 days

2018 ◽  
Vol 120 ◽  
pp. 213-221 ◽  
Author(s):  
Maria Bastaki ◽  
Michel Aubanel ◽  
Mark Bauter ◽  
Thierry Cachet ◽  
Jan Demyttenaere ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Effects of subchronic methyl tert-butyl ether ether exposure on male Sprague-Dawley rats

2009 ◽  
Vol 25 (1) ◽  
pp. 15-23 ◽  
Author(s):  
L Dong-mei ◽  
G Yi ◽  
Y Chun-tao ◽  
H Yu-feng ◽  
H Xiao-dong
Keyword(s):  
Adverse Effects ◽  
Blood Biochemistry ◽  
Organ Weight ◽  
Methyl Tert Butyl Ether ◽  
Sprague Dawley ◽  
Butyl Ether ◽  
Tert Butyl ◽  
Sprague Dawley Rats ◽  
Relative Organ Weight ◽  
Hematological Indicators

Methyl tert-butyl ether (MTBE) is an additive used to oxygenate gasoline to improve air quality by reducing tailpipe emissions of carbon monoxide and ozone precursors. Although several toxicity studies in rats have been conducted to examine the acute, subchronic, and chronic toxicities by employing various routes of exposure to MTBE, few data were available on the effects of MTBE exposure on blood. In this study, MTBE was administered to rats at dose levels of 0, 400, 800, and 1600 mg/kg/day, respectively. After 2- or 4-weeks treatment period, rats were euthanized and blood was collected for the assay of hematological indicators and blood biochemistry indicators. Some organs, including brain, heart, liver, spleen, lung, kidneys, testes, epididymis, thymus, and prostate, were immediately removed and weighed. Possible subchronic health effects of MTBE exposure by gavage were evaluated on mortality, body weight, relative organ weight, hematology, and blood biochemistry indicators in male Sprague-Dawley rats. The results indicated that MTBE did not disrupt the growth rate of rats. Relative organ weight showed change in heart, liver, kidney, testes, thymus, and prostate. In the 2-week treatment, MTBE exerted toxicity on white blood cell count, including lymphocyte, granulocyte, and eosinophil. This finding was especially strong at 1600 mg/kg/day MTBE. In the 4-week treatment, hemoglobin at high dose MTBE significantly increased. The results of the assay for the biochemistry indicators and relative organ weight indicated that MTBE could impair liver and kidney functions and also have adverse effects on lipid metabolism and immune system. It was conducted that subchronic MTBE exposure induced the adverse effects occurring in the relative organ weight, the hematological indicators, and the biochemistry indicators under high MTBE dose.

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