Adverse effects of neonatal exposure to 3,3′,4,4′,5,5′-hexachlorobiphenyl on hormone levels and testicular function in male Sprague-Dawley rats

2011 ◽  
Vol 26 (6) ◽  
pp. 657-668 ◽  
Author(s):  
Wusheng Xiao ◽  
Jie Zhang ◽  
Jiren Liang ◽  
Hongyan Zhu ◽  
Zhijun Zhou ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Neonatal Exposure ◽  
Testicular Function ◽  
Sprague Dawley ◽  
Hormone Levels ◽  
Sprague Dawley Rats

Effect of Gasohol on The Rat Liver

1997 ◽  
Vol 3 (S2) ◽  
pp. 49-50
Author(s):  
B.A. MacDuff ◽  
A. Singh ◽  
I. Chu
Keyword(s):  
United States ◽  
Body Weight ◽  
Adverse Effects ◽  
Rat Liver ◽  
Corn Oil ◽  
The United States ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Although there are a variety of gasoline ethanol mixtures proposed as neat fuels (ethanol 85% + gasoline 15% = E85; E95) for automobiles, gasohol (gasoline 90% + ethanol 10%) is presently used as a fuel in the United States. The adverse effects, if any, of gasohol ingestion are unknown; effects on the liver of rats administered gasohol are examined in this study.Twenty-four female Sprague-Dawley rats received daily, via gavage, one of the three concentrations of gasohol for 28 days; LD50/20, LD50/100 and LD50/1000, where LD50 = 1.5g ethanol / kg body weight (bw) and 14g gasoline / kg bw. The LD50 was based on that of gasoline, which was obtained from literature value.1 The amount of ethanol added to stock gasohol was only 1/10 its LD50, required to maintain the gasoline ethanol proportion of 9:1. Gasohol was administered in corn oil with total volume 10 ml. Animals that received only corn oil served as controls.

Absence of adverse effects following the gavage administration of methyl propyl trisulfide to Sprague-Dawley rats for 90 days

2018 ◽  
Vol 120 ◽  
pp. 544-551
Author(s):  
Maria Bastaki ◽  
Michel Aubanel ◽  
Thierry Cachet ◽  
Jan Demyttenaere ◽  
Maodo Malick Diop ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats

2001 ◽  
Vol 170 (3) ◽  
pp. 591-599 ◽  
Author(s):  
KS Weber ◽  
KD Setchell ◽  
DM Stocco ◽  
ED Lephart
Keyword(s):  
Enzyme Activity ◽  
Locomotor Activity ◽  
Plasma Testosterone ◽  
Sprague Dawley ◽  
Regulatory Peptide ◽  
Hormone Levels ◽  
Prostate Weight ◽  
Sprague Dawley Rats ◽  
Short Period ◽  
Steroidogenic Acute Regulatory

Nutritional factors, especially phytoestrogens, have been extensively studied for their potential beneficial effects against hormone-dependent and age-related diseases. The present study describes the short-term effects of dietary phytoestrogens on regulatory behaviors (food/water intake, locomotor activity and body weight), prostate weight, prostate 5alpha-reductase enzyme activity, reproductive hormone levels, and testicular steroidogenic acute regulatory peptide (StAR) levels in adult Sprague-Dawley rats. Animals were fed either a phytoestrogen-rich diet containing approximately 600 microg/g isoflavones (as determined by HPLC) or a phytoestrogen-free diet. After 5 weeks of consuming these diets, plasma phytoestrogen levels were 35 times higher in animals fed the phytoestrogen-rich vs phytoestrogen-free diets. Body and prostate weights were significantly decreased in animals fed the phytoestrogen-rich diet vs the phytoestrogen-free fed animals; however, no significant change in prostate 5alpha-reductase enzyme activity was observed between the treatment groups. Locomotor activity levels were higher in the phytoestrogen-rich vs the phytoestrogen-free animals during the course of the treatment interval. Plasma testosterone and androstenedione levels were significantly lower in the animals fed the phytoestrogen-rich diet compared with animals fed the phytoestrogen-free diet. However, there were no significant differences in plasma LH or estradiol levels between the diet groups. Testicular StAR levels were not significantly different between the phytoestrogen-rich vs the phytoestrogen-free fed animals. These results indicated that consumption of dietary phytoestrogens resulting in very high plasma isoflavone levels over a relatively short period can significantly alter body and prostate weight and plasma androgen hormone levels without affecting gonadotropin or testicular StAR levels. The findings of this study identify the biological actions of phytoestrogens on male reproductive endocrinology and provide insights into the protective effects these estrogen mimics exert in male reproductive disorders such as benign prostatic hyperplasia and prostate cancer.

LY294002, a PI3K pathway inhibitor, prevents leptin-induced adverse effects on spermatozoa in Sprague-Dawley rats

Andrologia ◽  
2018 ◽  
Vol 51 (3) ◽  
pp. e13196 ◽  
Author(s):  
Amir Hafidz Md Mokhtar ◽  
Ifrah Alam Malik ◽  
Noor Azean Anis Abd Aziz ◽  
Fayez A. Almabhouh ◽  
Damayanthi Durairajanayagam ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Pi3k Pathway ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Adverse effects of noise stress on glucose homeostasis and insulin resistance in Sprague-Dawley rats

Heliyon ◽  
2019 ◽  
Vol 5 (12) ◽  
pp. e03004 ◽  
Author(s):  
Ayodele Olufemi Morakinyo ◽  
Titilola Aderonke Samuel ◽  
Funmileyi Olubajo Awobajo ◽  
Daniel Abiodun Adekunbi ◽  
Idowu Olufemi Olatunji ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adverse Effects ◽  
Glucose Homeostasis ◽  
Sprague Dawley ◽  
Noise Stress ◽  
Sprague Dawley Rats

The effect of 20-week continuous 60 Hz magnetic field exposure on testicular function in sprague-dawley rats

2018 ◽  
Vol 39 (7) ◽  
pp. 539-546
Author(s):  
Sungman Park ◽  
Young-Jin Kim ◽  
Min Soo Kim ◽  
Hee-Sung Kim ◽  
Min-Woo Kim ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Testicular Function ◽  
Sprague Dawley ◽  
Field Exposure ◽  
Magnetic Field Exposure ◽  
Sprague Dawley Rats
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