Ethanol-induced damage in rat testis: oxidative stress-mediated germ cell apoptosis and vacuolization in Sertoli cells

Andrologia ◽  
2014 ◽  
Vol 47 (1) ◽  
pp. 3-3 ◽  
Author(s):  
N. Eid ◽  
Y. Ito ◽  
Y. Otsuki
Keyword(s):  
Oxidative Stress ◽  
Germ Cell ◽  
Sertoli Cells ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
Rat Testis

Germ cell apoptosis in rat testis after administration of 1,3-dinitrobenzene

1998 ◽  
Vol 12 (2) ◽  
pp. 97-103 ◽  
Author(s):  
Christina Strandgaard ◽  
Marion G. Miller
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
Rat Testis

Role of Sertoli Cells in Injury-Associated Testicular Germ Cell Apoptosis

2008 ◽  
Vol 225 (2) ◽  
pp. 105-115 ◽  
Author(s):  
Kim Boekelheide ◽  
Shawna L. Fleming ◽  
Kamin J. Johnson ◽  
Sutchin R. Patel ◽  
Heidi A. Schoenfeld
Keyword(s):  
Germ Cell ◽  
Sertoli Cells ◽  
Cell Apoptosis ◽  
Testicular Germ Cell ◽  
Germ Cell Apoptosis

hCG treatment raises H2O2 levels and induces germ cell apoptosis in rat testis

APOPTOSIS ◽  
2007 ◽  
Vol 12 (7) ◽  
pp. 1173-1182 ◽  
Author(s):  
Dinesh K. Gautam ◽  
M. M. Misro ◽  
S. P. Chaki ◽  
Mahesh Chandra ◽  
N. Sehgal
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
Rat Testis

scholarly journals Isoflurane impairs oogenesis through germ cell apoptosis in C. elegans

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tao Zhang ◽  
Cheng Ni ◽  
Cheng Li ◽  
Pan Lu ◽  
Dan Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Germ Cell ◽  
Fluorescence Imaging ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
C Elegans ◽  
Interaction Studies ◽  
Acetyl Cysteine ◽  
Induced Changes ◽  
And Oxidative Stress

AbstractAnesthetic isoflurane has been reported to induce toxicity. However, the effects of isoflurane on fecundity remain largely unknown. We established a system in C. elegans to investigate the effects of isoflurane on oogenesis. Synchronized L4 stage C. elegans were treated with 7% isoflurane for 4 h. Dead cells, ROS, embryos, and unfertilized eggs laid by hermaphrodites were measured by fluorescence imaging and counting. The C. elegans with losses of ced-3, cep-1, abl-1, male C. elegans, and oxidative stress inhibitor N-acetyl-cysteine were used in the interaction studies. We found that isoflurane decreased the numbers of embryos and unfertilized eggs and increased the levels of dead cells and ROS in C. elegans. The isoflurane-induced impairment of oogenesis was associated with abl-1, ced-3, but not cep-1. N-acetyl-cysteine attenuated the isoflurane-induced impairment of oogenesis in C. elegans. Mating with male C. elegans did not attenuate the isoflurane-induced changes in oogenesis. These findings suggest that isoflurane may impair oogenesis through abl-1- and ced-3-associated, but not cep-1-associated, germ cell apoptosis and oxidative stress, pending further investigation. These studies will promote more research to determine the potential effects of anesthesia on fecundity.

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