Diethyl maleate-induced oxidative stress leads to testicular germ cell apoptosis involving Bax and Bcl-2

2008 ◽  
Vol 22 (6) ◽  
pp. 371-381 ◽  
Author(s):  
Sumiti Kalia ◽  
M. P. Bansal
Keyword(s):  
Oxidative Stress ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Diethyl Maleate ◽  
Testicular Germ Cell ◽  
Germ Cell Apoptosis

Bcl-2 and Bax are involved in experimental cryptorchidism-induced testicular germ cell apoptosis in rhesus monkey

Contraception ◽  
2003 ◽  
Vol 68 (4) ◽  
pp. 297-301 ◽  
Author(s):  
Zhi-Hong Zhang ◽  
Xuan Jin ◽  
Xue-Sen Zhang ◽  
Zhao-Yuan Hu ◽  
Ru-Jin Zou ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Testicular Germ Cell ◽  
Germ Cell Apoptosis

MP66-13 14-3-3 EPSILON MAY PLAY AN IMPORTANT ROLE IN TESTICULAR GERM CELL APOPTOSIS: A FUNCTIONAL PROTEOMIC STUDIES OF EXPERIMENTAL VARICOCELE

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
Yan Zhang ◽  
Zhongmin Yuan ◽  
Qingqing He ◽  
Hao Zhang ◽  
Xiaopeng Liu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Testicular Germ Cell ◽  
Germ Cell Apoptosis

scholarly journals Vinclozolin Exposure in Utero Induces Postpubertal Prostatitis and Reduces Sperm Production via a Reversible Hormone-Regulated Mechanism

Endocrinology ◽  
2010 ◽  
Vol 151 (2) ◽  
pp. 783-792 ◽  
Author(s):  
Prue A. Cowin ◽  
Elspeth Gold ◽  
Jasna Aleksova ◽  
Moira K. O'Bryan ◽  
Paul M. D. Foster ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Reproductive Tract ◽  
Nuclear Factor Κb ◽  
In Utero ◽  
High Dose ◽  
Nuclear Factor ◽  
Testicular Germ Cell ◽  
Male Reproductive Tract ◽  
Germ Cell Apoptosis

Vinclozolin is an endocrine-disrupting chemical (EDC) that binds with high affinity to the androgen receptor (AR) and blocks the action of gonadal hormones on male reproductive organs. An alternative mechanism of action of Vinclozolin involves transgenerational effects on the male reproductive tract. We previously reported in utero Vinclozolin exposure-induced prostatitis (prostate inflammation) in postpubertal rats concurrent with down-regulation of AR and increased nuclear factor-κB activation. We postulated the male reproductive abnormalities induced by in utero Vinclozolin exposure could be reversed by testosterone supplementation, in contrast to the permanent modifications involving DNA methyltransferases (Dnmts) described by others. To test this hypothesis, we administered high-dose testosterone at puberty to Vinclozolin-treated rats and determined the effect on anogenital distance (AGD); testicular germ cell apoptosis, concentration of elongated spermatids, and the onset of prostatitis. Concurrently we examined Dnmt1, −3A, −3B, and −3L mRNA expression. Consistent with previous reports, in utero exposure to Vinclozolin significantly reduced AGD, increased testicular germ cell apoptosis 3-fold, reduced elongated spermatid number by 40%, and induced postpubertal prostatitis in 100% of exposed males. Administration of high-dose testosterone (25 mg/kg) at puberty normalized AGD, reduced germ cell apoptosis, and restored elongated spermatid number. Testosterone restored AR and nuclear factor-κB expression in the prostate and abolished Vinclozolin-induced prostatitis. Altered Dnmt expression was evident with in utero Vinclozolin exposure and was not normalized after testosterone treatment. These data demonstrate in utero Vinclozolin-induced male reproductive tract abnormalities are AR mediated and reversible and involve a mechanism independent of Dnmt expression.

FUNCTIONAL ROLE OF CASPASES IN HEAT-INDUCED TESTICULAR GERM CELL APOPTOSIS.

2004 ◽  
Vol 52 ◽  
pp. S99
Author(s):  
S. Rodriguez ◽  
Y. Vera ◽  
V. Pope ◽  
M. Castanares ◽  
R. S. Swerdloff ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Functional Role ◽  
Testicular Germ Cell ◽  
Germ Cell Apoptosis

Effects of losartan on experimental varicocele-induced testicular germ cell apoptosis

2016 ◽  
Vol 15 (5) ◽  
pp. e1247
Author(s):  
D. Bolat ◽  
F. Oltulu ◽  
A. Uysal ◽  
T. Kose ◽  
B. Gunlusoy ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Testicular Germ Cell ◽  
Germ Cell Apoptosis

scholarly journals Caspase-3 and Caspase-Activated Deoxyribonuclease Are Associated with Testicular Germ Cell Apoptosis Resulting from Reduced Intratesticular Testosterone

Endocrinology ◽  
2001 ◽  
Vol 142 (9) ◽  
pp. 3809-3816 ◽  
Author(s):  
Jong-Min Kim ◽  
Shampa R. Ghosh ◽  
Alexander C. P. Weil ◽  
Barry R. Zirkin
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Caspase 3 ◽  
Testicular Germ Cell ◽  
Germ Cell Apoptosis
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