Protective effect of Pumpkin seed extract on sperm characteristics, biochemical parameters and epididymal histology in adult male rats treated with Cyclophosphamide

Andrologia ◽  
2013 ◽  
Vol 46 (8) ◽  
pp. 927-935 ◽  
Author(s):  
S. Aghaei ◽  
H. Nikzad ◽  
M. Taghizadeh ◽  
A. A. Tameh ◽  
A. Taherian ◽  
...  
2016 ◽  
Vol 81 ◽  
pp. 439-452 ◽  
Author(s):  
Siti Hajar Adam ◽  
Nelli Giribabu ◽  
Normadiah Kassim ◽  
Kilari Eswar Kumar ◽  
Manuri Brahmayya ◽  
...  

2018 ◽  
Vol 391 (7) ◽  
pp. 729-742 ◽  
Author(s):  
Rania I. Nadeem ◽  
Hebatalla I. Ahmed ◽  
Bahia M. El-Sayeh

2010 ◽  
Vol 48 (8-9) ◽  
pp. 2206-2211 ◽  
Author(s):  
Virginia Alonso ◽  
Victoria Linares ◽  
Montserrat Bellés ◽  
María Luisa Albina ◽  
Andreu Pujol ◽  
...  

Author(s):  
Omer Mahrouf Ali Shoshin ◽  
Ahmed Abdulaali Azeez Baker ◽  
Evan Mohammed Mostafa ◽  
Noor Abdulaali Azeez Baker ◽  
Ahmad Salih Helal

2016 ◽  
Vol 21 (4) ◽  
pp. 250-253 ◽  
Author(s):  
Mohammad Waheed El-Anwar ◽  
Said Abdelmonem ◽  
Ebtessam Nada ◽  
Dalia Galhoom ◽  
Ahmed A. Abdelsameea

Objectives: To find out the possible protective effect of cilostazol against amikacin-induced ototoxicity. Methods: This study was carried out on 24 adult male rats classified into 4 equal groups of 6 animals each. (1) The control group was administered saline (1 ml/day, p.o.) for 14 days. (2) The amikacin group was administered amikacin (200 mg/kg, i.m.) once daily for 14 days. (3) The cilostazol-amikacin (14 days) group was administered cilostazol (30 mg/kg, p.o.) once daily and amikacin (200 mg/kg, i.m.) once daily for 14 days. (4) The cilostazol (28 days)-amikacin (14 days) group was administered cilostazol (30 mg/kg, p.o.) once daily for 28 days and amikacin (200 mg/kg, i.m.) once daily for 14 days. Changes in the transient evoked otoacoustic emissions (TEOAEs) in the 4 groups were interpreted statistically. Results: No reported significant differences in TEOAE levels were detected between the groups at the start of the study. In all frequency bands, TEOAEs disappeared after amikacin treatment in the amikacin-alone group and remained absent in the amikacin-cilostazol (14 days) group, while TEOAEs reappeared in the amikacin-cilostazol (28 days) group. Conclusion: Cilostazol treatment for 28 days had a protective effect against amikacin-induced ototoxicity in rats.


2018 ◽  
Vol 70 (3) ◽  
pp. 531-541 ◽  
Author(s):  
Ivan Radic ◽  
Vojkan Nestorovic ◽  
Milica Mijovic ◽  
Nikola Tatalovic ◽  
Bojan Joksimovic ◽  
...  

We studied the effects of whey and pumpkin seed oil supplementation on the biochemical parameters in blood serum of male rats after chronic ad libitum alcohol consumption. The levels of AST, ALT, total bilirubin, ALP, LDH, triglycerides, total cholesterol, HDL, LDL, VLDL, triglyceride/HDL ratio, total cholesterol/HDL ratio (cholesterol ratio) and LDL/HDL ratio (index of atherosclerosis) were determined in rats after six weeks of treatment with: (i) ethanol (12% ethanol, ad libitum), (ii) whey (2 g/kg per day), (iii) pumpkin seed oil (2 mL/kg per day), (iv) both ethanol and whey, and (v) both ethanol and pumpkin seed oil. The results showed no changes in the levels of AST, ALT, total bilirubin, ALP, total cholesterol, HDL and VLDL in alcoholic rats when compared to the controls (fed with a standard laboratory diet ad libitum) and rats supplemented with whey and pumpkin seed oil. Our results suggest that alcohol consumption in small doses for 6 weeks changes lipid metabolism and significantly elevates the LDL/HDL ratio (index of atherosclerosis) but does not induce extensive liver damage. Ethanol consumption in our experimental conditions lowered the triglyceride level as well as the triglyceride/HDL ratio, suggesting lipid redistribution and the induction of some cardio-protective effect. However, ethanol induced a higher index of atherosclerosis. Pumpkin seed oil showed some protective potential in alcoholic rats by lowering the total cholesterol/HDL ratio, but it elevated the LDH. Whey consumption prevented elevation of the atherosclerosis index, pointing to its protective role, probably through the redistribution of lipids. However, whey in combination with ethanol elevated LDH.


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