Birch pollen allergen‐specific immunotherapy with glutaraldehyde‐modified allergoid induces IL ‐10 secretion and protective antibody responses

Allergy ◽  
2019 ◽  
Author(s):  
Michèle Myriam Rauber ◽  
Hoi Ka Wu ◽  
Britta Adams ◽  
Julia Pickert ◽  
Barbara Bohle ◽  
...  
Keyword(s):  
Specific Immunotherapy ◽  
Birch Pollen ◽  
Antibody Responses ◽  
Pollen Allergen ◽  
Allergen Specific Immunotherapy ◽  
Protective Antibody ◽  
Birch Pollen Allergen

Genetic Engineering of Recombinant Hypoallergenic Oligomers of the Major Birch Pollen Allergen, Bet v 1: Candidates for Specific Immunotherapy

1999 ◽  
Vol 118 (2-4) ◽  
pp. 218-219 ◽  
Author(s):  
Susanne Vrtala ◽  
Kora Hirtenlehner ◽  
Markus Susani ◽  
Peter Hufnagl ◽  
Bernd R. Binder ◽  
...  
Keyword(s):  
Genetic Engineering ◽  
Specific Immunotherapy ◽  
Birch Pollen ◽  
Pollen Allergen ◽  
Bet V 1 ◽  
Birch Pollen Allergen

Patient management plan for sublingual allergen specific immunotherapy with birch pollen allergen and the maintenance of patient compliance

2020 ◽  
Vol 17 (3) ◽  
pp. 64-73
Author(s):  
Olga V. Trusova ◽  
Andrey V. Kamaev ◽  
Irina V. Makarova
Keyword(s):  
Side Effects ◽  
Patient Management ◽  
Specific Immunotherapy ◽  
Birch Pollen ◽  
Management Plan ◽  
Allergen Specific Immunotherapy ◽  
Treatment Termination ◽  
Birch Pollen Allergen ◽  
Retention In Treatment ◽  
Patient Retention

BACKGROUND:Sublingual allergen-specific immunotherapy (SLIT) inefficiencie is mainly caused by non-compliance with the treatment regimen and premature treatment termination. AIM:Frequency and causes of dropouts determination in children receiving SLIT with birch pollen according to the pre-coseasonal protocol, and approbation of the developed visit-to-visit patient management plan (Plan). MATERIALS AND METHODS:332 cases of treatment with birch pollen in children are analyzed. 290 patients (72.1% boys, aged 518 years (9.82 years [5.93; 14.67]), received SLIT with birch pollen in 20122019. 42 patients received SLIT according to the Plan (69% boys, 8.95 years old [5.38; 11.79]) in 20172019. RESULTS:A low dropout frequency was noted in the 1st and 2nd year of therapy (2 years after the start of treatment, 85% patients continue it). However, only 63.1% complete 3 years of therapy, and 11% 4 years of therapy. It has been shown that experienced allergists have more efficient patient retention. The implementation of the Plan increased patient retention in treatment at the 3rdyear of treatment up to 82.9% (p=0.02). CONCLUSION:The study confirmed the main reasons for the withdrawal of patients from SLIT: doubts about the effectiveness, cost and side effects. A low dropout frequency was shown according to the results of the 1stand 2ndyears of therapy, but only a small proportion of patients (11%) receive 4 or more courses of therapy. Visit-to-visit Plan optimizes the patients management, reduces patients withdrawal from treatment and can be recommended for practical healthcare.

scholarly journals Caveolar transport through nasal epithelium of birch pollen allergen Bet v 1 in allergic patients

2009 ◽  
Vol 124 (1) ◽  
pp. 135-142.e21 ◽  
Author(s):  
Sakari Joenväärä ◽  
Pirkko Mattila ◽  
Jutta Renkonen ◽  
Antti Mäkitie ◽  
Sanna Toppila-Salmi ◽  
...  
Keyword(s):  
Birch Pollen ◽  
Pollen Allergen ◽  
Nasal Epithelium ◽  
Bet V 1 ◽  
Birch Pollen Allergen

scholarly journals Genetic Variants in CHIA and CHI3L1 Are Associated with the IgE Response to the Ascaris Resistance Marker ABA-1 and the Birch Pollen Allergen Bet v 1

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167453 ◽  
Author(s):  
Nathalie Acevedo ◽  
Adriana Bornacelly ◽  
Dilia Mercado ◽  
Per Unneberg ◽  
Irene Mittermann ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Birch Pollen ◽  
Pollen Allergen ◽  
Resistance Marker ◽  
Bet V 1 ◽  
Birch Pollen Allergen ◽  
Ige Response

scholarly journals Birch pollen allergen immunotherapy reprograms nasal epithelial transcriptome and recovers microbial diversity

2019 ◽  
Vol 143 (6) ◽  
pp. 2293-2296.e11 ◽  
Author(s):  
Tanzeela Hanif ◽  
Kishor Dhaygude ◽  
Matti Kankainen ◽  
Jutta Renkonen ◽  
Pirkko Mattila ◽  
...  
Keyword(s):  
Microbial Diversity ◽  
Allergen Immunotherapy ◽  
Birch Pollen ◽  
Pollen Allergen ◽  
Birch Pollen Allergen
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