Genetic Engineering of Recombinant Hypoallergenic Oligomers of the Major Birch Pollen Allergen, Bet v 1: Candidates for Specific Immunotherapy

1999 ◽  
Vol 118 (2-4) ◽  
pp. 218-219 ◽  
Author(s):  
Susanne Vrtala ◽  
Kora Hirtenlehner ◽  
Markus Susani ◽  
Peter Hufnagl ◽  
Bernd R. Binder ◽  
...  
Keyword(s):  
Genetic Engineering ◽  
Specific Immunotherapy ◽  
Birch Pollen ◽  
Pollen Allergen ◽  
Bet V 1 ◽  
Birch Pollen Allergen

scholarly journals Genetic engineering of trimers of hypoallergenic fragments of the major birch pollen allergen, Bet v 1, for allergy vaccination

Vaccine ◽  
2011 ◽  
Vol 29 (11) ◽  
pp. 2140-2148 ◽  
Author(s):  
Susanne Vrtala ◽  
Monika Fohr ◽  
Raffaela Campana ◽  
Christian Baumgartner ◽  
Peter Valent ◽  
...  
Keyword(s):  
Genetic Engineering ◽  
Birch Pollen ◽  
Pollen Allergen ◽  
Bet V 1 ◽  
Birch Pollen Allergen

Genetic engineering of a hypoallergenic trimer of the major birch pollen allergen, Bet v 1

2001 ◽  
Vol 15 (11) ◽  
pp. 2045-2047 ◽  
Author(s):  
Susanne Vrtala, ◽  
Kora Hirtenlehner ◽  
Markus Susani ◽  
Mübeccel Akdis ◽  
Fatimah Kussebi ◽  
...  
Keyword(s):  
Genetic Engineering ◽  
Birch Pollen ◽  
Pollen Allergen ◽  
Bet V 1 ◽  
Birch Pollen Allergen

scholarly journals Caveolar transport through nasal epithelium of birch pollen allergen Bet v 1 in allergic patients

2009 ◽  
Vol 124 (1) ◽  
pp. 135-142.e21 ◽  
Author(s):  
Sakari Joenväärä ◽  
Pirkko Mattila ◽  
Jutta Renkonen ◽  
Antti Mäkitie ◽  
Sanna Toppila-Salmi ◽  
...  
Keyword(s):  
Birch Pollen ◽  
Pollen Allergen ◽  
Nasal Epithelium ◽  
Bet V 1 ◽  
Birch Pollen Allergen

scholarly journals Genetic Variants in CHIA and CHI3L1 Are Associated with the IgE Response to the Ascaris Resistance Marker ABA-1 and the Birch Pollen Allergen Bet v 1

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167453 ◽  
Author(s):  
Nathalie Acevedo ◽  
Adriana Bornacelly ◽  
Dilia Mercado ◽  
Per Unneberg ◽  
Irene Mittermann ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Birch Pollen ◽  
Pollen Allergen ◽  
Resistance Marker ◽  
Bet V 1 ◽  
Birch Pollen Allergen ◽  
Ige Response

Two members of the Bet v 1 gene family encoding birch pathogenesis-related proteins display different patterns of root expression and wound-inducibility

1998 ◽  
Vol 25 (4) ◽  
pp. 459 ◽  
Author(s):  
Pascal Poupard ◽  
Désiré-Georges Strullu ◽  
Philippe Simoneau
Keyword(s):  
Birch Pollen ◽  
Polyclonal Antiserum ◽  
Pollen Allergen ◽  
Pathogenesis Related Proteins ◽  
Bet V 1 ◽  
New Family ◽  
Pathogenesis Related ◽  
Birch Pollen Allergen ◽  
Root Organogenesis ◽  
Related Proteins

Bet v 1-SC genes constitute a subset of a multigene family in birch (Betula pendula Roth) that includes the gene for the major pollen allergen and encode proteins belonging to a new family of intracellular pathogenesis-related proteins. We have investigated the expression in birch roots of the Bet v 1-SC1 and Bet v 1-SC3 genes by northern and reverse-transcription-polymerase chain reaction analyses. Only Bet v 1-SC3 was found to be highly expressed in roots under basal conditions but this gene was not wound-inducible. Conversely the expression of the Bet v 1-SC1 gene was markedly transiently induced 8 to 9 h after the stress. Immunoblotting with polyclonal antiserum raised against the major birch pollen allergen confirmed that Bet v 1-related polypeptides are present in root extracts. This first report of Bet v 1-SC gene expression and wound-inducibility in birch roots suggests a possible function of proteins encoded by these genes in plant defense and/or root organogenesis.

Mimotopes of birch pollen allergen Bet v 1 conjugated to albumin inhibit antibody binding to the natural antigen

2002 ◽  
Vol 109 (1) ◽  
pp. S130-S130
Author(s):  
Angelika Riemer ◽  
Isabella Schoell ◽  
Farideh Nasseri-Kia ◽  
Claudia Gusenbauer ◽  
Margarete Focke ◽  
...  
Keyword(s):  
Birch Pollen ◽  
Antibody Binding ◽  
Pollen Allergen ◽  
Bet V 1 ◽  
Birch Pollen Allergen ◽  
Inhibit Antibody
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