scholarly journals Vitamin D insufficiency in the first 6 months of infancy and challenge-proven IgE-mediated food allergy at 1 year of age: a case-cohort study

Allergy ◽  
2017 ◽  
Vol 72 (8) ◽  
pp. 1222-1231 ◽  
Author(s):  
J. Molloy ◽  
J. J. Koplin ◽  
K. J. Allen ◽  
M. L. K. Tang ◽  
F. Collier ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Food Allergy ◽  
Vitamin D Insufficiency ◽  
Ige Mediated

scholarly journals Vitamin D insufficiency is associated with challenge-proven food allergy in infants

2013 ◽  
Vol 131 (4) ◽  
pp. 1109-1116.e6 ◽  
Author(s):  
Katrina J. Allen ◽  
Jennifer J. Koplin ◽  
Anne-Louise Ponsonby ◽  
Lyle C. Gurrin ◽  
Melissa Wake ◽  
...  
Keyword(s):  
Vitamin D ◽  
Food Allergy ◽  
Vitamin D Insufficiency

Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease-specific Cork BASELINE Birth Cohort Study

Allergy ◽  
2018 ◽  
Vol 73 (11) ◽  
pp. 2182-2191 ◽  
Author(s):  
Áine Hennessy ◽  
Jonathan O'B Hourihane ◽  
Lucio Malvisi ◽  
Alan D. Irvine ◽  
Louise C. Kenny ◽  
...  
Keyword(s):  
Vitamin D ◽  
Allergic Rhinitis ◽  
Cohort Study ◽  
Food Allergy ◽  
Birth Cohort ◽  
Atopic Disease ◽  
Birth Cohort Study ◽  
Disease Specific

scholarly journals Implications of Vitamin D Levels in COVID-19 Morbidity and Mortality

2020 ◽  
pp. 2-3
Author(s):  
Seyedeh Niki Sadat Afjeh ◽  
Nahal Emami Fard ◽  
Paniz Poursharif
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Clinical Outcomes ◽  
Vitamin D Insufficiency ◽  
T Regulatory Cell ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Randomized Controlled Studies ◽  
Vitamin D Levels ◽  
One Year

Vitamin D is a steroid hormone known for maintaining bone health. Vitamin D deficiency is a 25-hydroxyvitamin D (25(OH)D) serum concentration below 25 nmol/L. In contrast, vitamin D insufficiency occurs at levels below 75 nmol/L. Vitamin D insufficiency and deficiency affect 70% and 30% of the US population, respectively. Emerging evidence associates optimal vitamin D levels with better clinical outcomes in COVID-19. This literature review analyzed three preliminary articles that explored associations between vitamin D levels, COVID-19 mortality, and risk of adverse clinical outcomes in adult hospitalized patients. Google Scholar was used to find studies that diagnosed COVID-19 with reverse transcription (RT-PCR). In a cross-sectional analysis, Maghbooli et al. (2020) reported that vitamin D sufficient patients had a significantly lower chance (9.7%, n=77, p=0.01) of severe COVID-19 complications than deficient patients (32.8%, n=158, p=0.01). This study is under review for diagnosis accuracy and sample size. A retrospective cohort study by Raharusun et al. (2020), which included active and expired cases (n=780), found that 98.9% (p<0.001) of vitamin D deficient COVID-19 patients and 88% (p<0.001) with insufficiency died, but only 4% of sufficient individuals died. Lastly, a retroactive cohort study by Meltzer et al. (2020) reported higher rates of COVID-19 infection, 21.6% (95% CI, 14.0-29.2%), in vitamin D deficient groups (n=172), compared to 12.2% (95% CI, 8.5-15.4%) in sufficient groups (n=327). The 25(OH)D levels were measured within one year of COVID-19 testing. All studies controlled for age, sex, and comorbidities, while the first controlled for BMI and smoking, and the third controlled for race. Vitamin D sufficiency may activate the innate and adaptive immune systems, leading to an antiviral response. Receptor binding of vitamin D on neutrophils and macrophages stimulates cathelicidin expression, an antibacterial peptide. Macrophage and T-regulatory cell quantities also increase. These results reveal the need for randomized controlled studies of vitamin D sufficiency as a potential mitigator in COVID-19 outcomes.

A prospective cohort study of vitamin D in optic neuritis recovery

2016 ◽  
Vol 23 (1) ◽  
pp. 82-93 ◽  
Author(s):  
Jodie M Burton ◽  
Misha Eliasziw ◽  
Jessie Trufyn ◽  
Chelsia Tung ◽  
Gorden Carter ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Optic Neuritis ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Female Gender ◽  
Vitamin D Insufficiency ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Acute Optic Neuritis

Background: Vitamin D sufficiency is associated with better inflammatory outcomes in multiple sclerosis (MS). We hypothesize that it is also associated with better long-term neurodegenerative measures. Objectives: To show that vitamin D sufficient patients (25-hydroxy vitamin D (25(OH)D) > 80 nmol/L) have better optical coherence tomography (OCT) neuroaxonal measures of ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) thickness after optic neuritis. Methods: In this prospective cohort study, acute optic neuritis patients underwent OCT and serum 25(OH)D assessments at baseline and at month 6, with comparisons between vitamin D sufficient and insufficient patients, and men and women. Potential confounding variables were evaluated. Results: Of 49 enrolled, 36 had complete, analyzable data. At baseline, vitamin D insufficiency was associated with greater RNFL thickness (134.3 vs. 95.2 µm; p = 0.003) in affected eyes. At month 6, insufficient patients had greater GCL thinning (GCL inter-eye difference: 14.2 vs. 4.0 µm, p = 0.008). Men had greater RNFL and GCL thinning than women (GCL: 61.2 vs. 69.6 µm, p = 0.036). Conclusion: Acutely, in optic neuritis, RNFL thickness is increased with vitamin D insufficiency. Chronically, neuronal, and possibly axonal loss are associated with vitamin D insufficiency and male gender, suggesting vitamin D and female gender may confer neuroprotection in optic neuritis, and possibly, central nervous system (CNS) inflammatory disease.

Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study

Allergy ◽  
2012 ◽  
Vol 68 (2) ◽  
pp. 220-228 ◽  
Author(s):  
K. Weisse ◽  
S. Winkler ◽  
F. Hirche ◽  
G. Herberth ◽  
D. Hinz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Food Allergy ◽  
Vitamin D Status ◽  
Maternal And Newborn

scholarly journals Food allergy prevention, including early food introduction

2020 ◽  
Vol 2 (1) ◽  
pp. 69-74
Author(s):  
Stephanie A. Leonard
Keyword(s):  
Vitamin D ◽  
Food Allergy ◽  
Infant Feeding ◽  
Peanut Allergy ◽  
Diet Composition ◽  
Immunoglobulin E ◽  
Allergy Prevention ◽  
Early Interventions ◽  
Infant Feeding Practices ◽  
Ige Mediated

As the prevalence of immunoglobulin E (IgE)-mediated food allergy continues to increase without an imminent cure, prevention has become an urgent need. A breakthrough study that shows that early consumption of peanut can prevent the development of peanut allergy has led for a push in early interventions. Theories associated with the increasing prevalence of food allergy lend themselves to areas of potential intervention, e.g., age at time of food introduction, infant feeding practices, microbiome influences, diet composition, vitamin D deficiency, and increasing rates of eczema. This review focused on the available data from studies that investigated early interventions to decrease the risk of food allergy.

scholarly journals Vitamin D insufficiency over 5 years is associated with increased fracture risk—an observational cohort study of elderly women

2014 ◽  
Vol 25 (12) ◽  
pp. 2767-2775 ◽  
Author(s):  
D. Buchebner ◽  
F. McGuigan ◽  
P. Gerdhem ◽  
J. Malm ◽  
M. Ridderstråle ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Fracture Risk ◽  
Elderly Women ◽  
Vitamin D Insufficiency ◽  
Observational Cohort Study ◽  
Observational Cohort
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