scholarly journals Job strain and the risk of severe asthma exacerbations: a meta-analysis of individual-participant data from 100 000 European men and women

Allergy ◽  
2014 ◽  
Vol 69 (6) ◽  
pp. 775-783 ◽  
Author(s):  
K. Heikkilä ◽  
I. E. H. Madsen ◽  
S. T. Nyberg ◽  
E. I. Fransson ◽  
H. Westerlund ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Job Strain ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
Men And Women ◽  
Asthma Exacerbations ◽  
Individual Participant

scholarly journals Job Strain and Alcohol Intake: A Collaborative Meta-Analysis of Individual-Participant Data from 140 000 Men and Women

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40101 ◽  
Author(s):  
Katriina Heikkilä ◽  
Solja T. Nyberg ◽  
Eleonor I. Fransson ◽  
Lars Alfredsson ◽  
Dirk De Bacquer ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Job Strain ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
Men And Women ◽  
Individual Participant

ADRB2 Haplotypes and Asthma Exacerbations in Children and Young Adults: An Individual Participant Data Meta‐Analysis

2021 ◽  
Author(s):  
Leila Karimi ◽  
Susanne J. Vijverberg ◽  
Marjolein Engelkes ◽  
Natalia Hernandez‐Pacheco ◽  
Niloufar Farzan ◽  
...  
Keyword(s):  
Young Adults ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
Asthma Exacerbations ◽  
Individual Participant ◽  
Children And Young Adults

scholarly journals Job Strain and Tobacco Smoking: An Individual-Participant Data Meta-Analysis of 166 130 Adults in 15 European Studies

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e35463 ◽  
Author(s):  
Katriina Heikkilä ◽  
Solja T. Nyberg ◽  
Eleonor I. Fransson ◽  
Lars Alfredsson ◽  
Dirk De Bacquer ◽  
...  
Keyword(s):  
Tobacco Smoking ◽  
Job Strain ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
European Studies ◽  
Individual Participant

scholarly journals Job Strain and the Risk of Inflammatory Bowel Diseases: Individual-Participant Meta-Analysis of 95 000 Men and Women

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88711 ◽  
Author(s):  
Katriina Heikkilä ◽  
Ida E. H. Madsen ◽  
Solja T. Nyberg ◽  
Eleonor I. Fransson ◽  
Kirsi Ahola ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Job Strain ◽  
Meta Analysis ◽  
Men And Women ◽  
Bowel Diseases ◽  
Individual Participant ◽  
Inflammatory Bowel

scholarly journals Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data

The Lancet ◽  
2012 ◽  
Vol 380 (9852) ◽  
pp. 1491-1497 ◽  
Author(s):  
Mika Kivimäki ◽  
Solja T Nyberg ◽  
G David Batty ◽  
Eleonor I Fransson ◽  
Katriina Heikkilä ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Job Strain ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
Individual Participant

scholarly journals Study protocol for examining job strain as a risk factor for severe unipolar depression in an individual participant meta-analysis of 14 European cohorts

F1000Research ◽  
2014 ◽  
Vol 2 ◽  
pp. 233 ◽  
Author(s):  
Ida E. H. Madsen ◽  
Harald Hannerz ◽  
Solja T. Nyberg ◽  
Linda L. Magnusson Hanson ◽  
Kirsi Ahola ◽  
...  
Keyword(s):  
Publication Bias ◽  
Study Protocol ◽  
Job Strain ◽  
Meta Analysis ◽  
Unipolar Depression ◽  
Hospital Treatment ◽  
Individual Participant Data ◽  
Risk Estimates ◽  
Increased Risk ◽  
Individual Participant

Background: Previous studies have shown that gainfully employed individuals with high work demands and low control at work (denoted “job strain”) are at increased risk of common mental disorders, including depression. Most existing studies have, however, measured depression using self-rated symptom scales that do not necessarily correspond to clinically diagnosed depression. In addition, a meta-analysis from 2008 indicated publication bias in the field. Methods: This study protocol describes the planned design and analyses of an individual participant data meta-analysis, to examine whether job strain is associated with an increased risk of clinically diagnosed unipolar depression based on hospital treatment registers.  The study will be based on data from approximately 120,000 individuals who participated in 14 studies on work environment and health in 4 European countries. The self-reported working conditions data will be merged with national registers on psychiatric hospital treatment, primarily hospital admissions. Study-specific risk estimates for the association between job strain and depression will be calculated using Cox regressions. The study-specific risk estimates will be pooled using random effects meta-analysis. Discussion: The planned analyses will help clarify whether job strain is associated with an increased risk of clinically diagnosed unipolar depression. As the analysis is based on pre-planned study protocols and an individual participant data meta-analysis, the pooled risk estimates will not be influenced by selective reporting and publication bias. However, the results of the planned study may only pertain to severe cases of unipolar depression, because of the outcome measure applied.

scholarly journals Does maintenance azithromycin reduce asthma exacerbations? An individual participant data meta-analysis

2019 ◽  
Vol 54 (5) ◽  
pp. 1901381 ◽  
Author(s):  
Sarah A. Hiles ◽  
Vanessa M. McDonald ◽  
Michelle Guilhermino ◽  
Guy G. Brusselle ◽  
Peter G. Gibson
Keyword(s):  
Severe Asthma ◽  
Oral Corticosteroid ◽  
Meta Analysis ◽  
Emergency Department Visits ◽  
Cochrane Library ◽  
Individual Participant Data ◽  
Double Blind ◽  
Eosinophilic Asthma ◽  
Long Term Treatment ◽  
Individual Participant

BackgroundPreventing exacerbations is an important goal of asthma treatment. Long-term treatment with azithromycin may help achieve this. Our aim was to conduct a systematic review and individual participant data (IPD) meta-analysis to examine the efficacy of azithromycin in reducing exacerbations in asthma, and in the subphenotypes of noneosinophilic asthma, eosinophilic asthma and severe asthma.MethodWe completed a systematic search of Embase, MEDLINE, PubMed, Cochrane Library, ClinicalTrials.gov and reference lists of previous systematic reviews in February 2019. We included parallel-group, double-blind, randomised controlled trials in adults comparing at least 8 weeks of azithromycin treatment with placebo, where the outcome of exacerbations was assessed over at least 6 months. Data were extracted from published sources, Cochrane Risk of Bias Tool was applied and IPD were sought from authors. Reviews were undertaken in duplicate. We conducted an IPD meta-analysis on the primary outcome of exacerbations and a random effects meta-analysis for secondary outcomes.ResultsThree studies were identified (n=604). In the IPD meta-analysis, treatment with azithromycin was associated with a reduced rate of exacerbations (oral corticosteroid course due to worsening asthma, antibiotic use for lower respiratory tract infection, hospitalisation and/or emergency department visits) in asthma as well as in the noneosinophilic, eosinophilic and severe asthma subgroups. Examining each exacerbation type separately, patients with eosinophilic asthma reported fewer oral corticosteroid courses, and patients with noneosinophilic and severe asthma reported fewer antibiotic courses. Azithromycin was well tolerated.DiscussionMaintenance use of azithromycin reduces exacerbations in patients with eosinophilic, noneosinophilic and severe asthma.

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