scholarly journals Job Strain as a Risk Factor for Leisure-Time Physical Inactivity: An Individual-Participant Meta-Analysis of Up to 170,000 Men and Women: The IPD-Work Consortium

2012 ◽  
Vol 176 (12) ◽  
pp. 1078-1089 ◽  
Author(s):  
E. I. Fransson ◽  
K. Heikkila ◽  
S. T. Nyberg ◽  
M. Zins ◽  
H. Westerlund ◽  
...  
Keyword(s):  
Risk Factor ◽  
Physical Inactivity ◽  
Leisure Time ◽  
Job Strain ◽  
Meta Analysis ◽  
Men And Women ◽  
Individual Participant

scholarly journals Job strain and the risk of severe asthma exacerbations: a meta-analysis of individual-participant data from 100 000 European men and women

Allergy ◽  
2014 ◽  
Vol 69 (6) ◽  
pp. 775-783 ◽  
Author(s):  
K. Heikkilä ◽  
I. E. H. Madsen ◽  
S. T. Nyberg ◽  
E. I. Fransson ◽  
H. Westerlund ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Job Strain ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
Men And Women ◽  
Asthma Exacerbations ◽  
Individual Participant

scholarly journals Job Strain and the Risk of Inflammatory Bowel Diseases: Individual-Participant Meta-Analysis of 95 000 Men and Women

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88711 ◽  
Author(s):  
Katriina Heikkilä ◽  
Ida E. H. Madsen ◽  
Solja T. Nyberg ◽  
Eleonor I. Fransson ◽  
Kirsi Ahola ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Job Strain ◽  
Meta Analysis ◽  
Men And Women ◽  
Bowel Diseases ◽  
Individual Participant ◽  
Inflammatory Bowel

scholarly journals Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data

The Lancet ◽  
2012 ◽  
Vol 380 (9852) ◽  
pp. 1491-1497 ◽  
Author(s):  
Mika Kivimäki ◽  
Solja T Nyberg ◽  
G David Batty ◽  
Eleonor I Fransson ◽  
Katriina Heikkilä ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Job Strain ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
Individual Participant

scholarly journals Job Strain and Alcohol Intake: A Collaborative Meta-Analysis of Individual-Participant Data from 140 000 Men and Women

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40101 ◽  
Author(s):  
Katriina Heikkilä ◽  
Solja T. Nyberg ◽  
Eleonor I. Fransson ◽  
Lars Alfredsson ◽  
Dirk De Bacquer ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Job Strain ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
Men And Women ◽  
Individual Participant

scholarly journals Job strain as a risk factor for clinical depression: systematic review and meta-analysis with additional individual participant data

2017 ◽  
Vol 47 (8) ◽  
pp. 1342-1356 ◽  
Author(s):  
I. E. H. Madsen ◽  
S. T. Nyberg ◽  
L. L. Magnusson Hanson ◽  
J. E. Ferrie ◽  
K. Ahola ◽  
...  
Keyword(s):  
Risk Factor ◽  
Depressive Symptoms ◽  
Job Strain ◽  
Meta Analysis ◽  
Clinical Depression ◽  
Individual Participant Data ◽  
Individual Level ◽  
Level Data ◽  
Increased Risk ◽  
Individual Participant

BackgroundAdverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for clinical depression.MethodWe identified published cohort studies from a systematic literature search in PubMed and PsycNET and obtained 14 cohort studies with unpublished individual-level data from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium. Summary estimates of the association were obtained using random-effects models. Individual-level data analyses were based on a pre-published study protocol.ResultsWe included six published studies with a total of 27 461 individuals and 914 incident cases of clinical depression. From unpublished datasets we included 120 221 individuals and 982 first episodes of hospital-treated clinical depression. Job strain was associated with an increased risk of clinical depression in both published [relative risk (RR) = 1.77, 95% confidence interval (CI) 1.47–2.13] and unpublished datasets (RR = 1.27, 95% CI 1.04–1.55). Further individual participant analyses showed a similar association across sociodemographic subgroups and after excluding individuals with baseline somatic disease. The association was unchanged when excluding individuals with baseline depressive symptoms (RR = 1.25, 95% CI 0.94–1.65), but attenuated on adjustment for a continuous depressive symptoms score (RR = 1.03, 95% CI 0.81–1.32).ConclusionsJob strain may precipitate clinical depression among employees. Future intervention studies should test whether job strain is a modifiable risk factor for depression.

scholarly journals Pregnancy as a risk factor for severe influenza infection: an individual participant data meta-analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Dominik Mertz ◽  
◽  
Calvin Ka-Fung Lo ◽  
Lyubov Lytvyn ◽  
Justin R. Ortiz ◽  
...  
Keyword(s):  
Risk Factor ◽  
Influenza Infection ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
Severe Influenza ◽  
Individual Participant

scholarly journals Job Strain and Tobacco Smoking: An Individual-Participant Data Meta-Analysis of 166 130 Adults in 15 European Studies

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e35463 ◽  
Author(s):  
Katriina Heikkilä ◽  
Solja T. Nyberg ◽  
Eleonor I. Fransson ◽  
Lars Alfredsson ◽  
Dirk De Bacquer ◽  
...  
Keyword(s):  
Tobacco Smoking ◽  
Job Strain ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
European Studies ◽  
Individual Participant

scholarly journals Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis

BMJ ◽  
2019 ◽  
pp. l1495 ◽  
Author(s):  
Mika Kivimäki ◽  
Archana Singh-Manoux ◽  
Jaana Pentti ◽  
Séverine Sabia ◽  
Solja T Nyberg ◽  
...  
Keyword(s):  
Physical Activity ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Physical Inactivity ◽  
Meta Analysis ◽  
Hazard Ratio ◽  
Cardiometabolic Disease ◽  
Reverse Causation ◽  
Individual Participant ◽  
Incident Cases

AbstractObjectiveTo examine whether physical inactivity is a risk factor for dementia, with attention to the role of cardiometabolic disease in this association and reverse causation bias that arises from changes in physical activity in the preclinical (prodromal) phase of dementia.DesignMeta-analysis of 19 prospective observational cohort studies.Data sourcesThe Individual-Participant-Data Meta-analysis in Working Populations Consortium, the Inter-University Consortium for Political and Social Research, and the UK Data Service, including a total of 19 of a potential 9741 studies.Review methodThe search strategy was designed to retrieve individual-participant data from prospective cohort studies. Exposure was physical inactivity; primary outcomes were incident all-cause dementia and Alzheimer’s disease; and the secondary outcome was incident cardiometabolic disease (that is, diabetes, coronary heart disease, and stroke). Summary estimates were obtained using random effects meta-analysis.ResultsStudy population included 404 840 people (mean age 45.5 years, 57.7% women) who were initially free of dementia, had a measurement of physical inactivity at study entry, and were linked to electronic health records. In 6.0 million person-years at risk, we recorded 2044 incident cases of all-cause dementia. In studies with data on dementia subtype, the number of incident cases of Alzheimer’s disease was 1602 in 5.2 million person-years. When measured <10 years before dementia diagnosis (that is, the preclinical stage of dementia), physical inactivity was associated with increased incidence of all-cause dementia (hazard ratio 1.40, 95% confidence interval 1.23 to 1.71) and Alzheimer’s disease (1.36, 1.12 to 1.65). When reverse causation was minimised by assessing physical activity ≥10 years before dementia onset, no difference in dementia risk between physically active and inactive participants was observed (hazard ratios 1.01 (0.89 to 1.14) and 0.96 (0.85 to 1.08) for the two outcomes). Physical inactivity was consistently associated with increased risk of incident diabetes (hazard ratio 1.42, 1.25 to 1.61), coronary heart disease (1.24, 1.13 to 1.36), and stroke (1.16, 1.05 to 1.27). Among people in whom cardiometabolic disease preceded dementia, physical inactivity was non-significantly associated with dementia (hazard ratio for physical activity assessed >10 before dementia onset 1.30, 0.79 to 2.14).ConclusionsIn analyses that addressed bias due to reverse causation, physical inactivity was not associated with all-cause dementia or Alzheimer’s disease, although an indication of excess dementia risk was observed in a subgroup of physically inactive individuals who developed cardiometabolic disease.

scholarly journals Job Strain as a Risk Factor for Type 2 Diabetes: A Pooled Analysis of 124,808 Men and Women

Diabetes Care ◽  
2014 ◽  
Vol 37 (8) ◽  
pp. 2268-2275 ◽  
Author(s):  
Solja T. Nyberg ◽  
Eleonor I. Fransson ◽  
Katriina Heikkilä ◽  
Kirsi Ahola ◽  
Lars Alfredsson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Factor ◽  
Job Strain ◽  
Pooled Analysis ◽  
Men And Women
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