scholarly journals True effect of monoclonal Antibody for COVID‐19 in kidney transplant recipients

2021 ◽  
Author(s):  
Akshay Khatri ◽  
Mohammed Raja ◽  
Giselle Guerra ◽  
Yoichiro Natori
Keyword(s):  
Monoclonal Antibody ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
True Effect

Mycophenolate mofetil, together with cyclosporin A, prevents anti-OKT3 antibody response in kidney transplant recipients.

1998 ◽  
Vol 9 (8) ◽  
pp. 1521-1525
Author(s):  
N Broeders ◽  
K M Wissing ◽  
A Crusiaux ◽  
P Kinnaert ◽  
P Vereerstraeten ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Mycophenolate Mofetil ◽  
Kidney Transplant ◽  
Humoral Response ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Levels ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Serum Samples ◽  
The Impact

OKT3 monoclonal antibody, a murine IgG2a monoclonal antibody targeting the T cell CD3 antigen, elicits a neutralizing humoral response in 20 to 50% of kidney transplant recipients when the concomitant immunosuppression consists of CsA-Sandimmun (SAND) and azathioprine (AZA). In the present study, we investigated the impact of the newer agents, CsA-Neoral (NEO) and mycophenolate mofetil (MMF) on OKT3 sensitization. Sixty-two consecutive kidney transplant recipients received prophylactic OKT3 (5 mg/d) from days 0 to 13, together with steroids. Concomitant immunosuppression consisted of either AZA + SAND (n=20), AZA + NEO (n=31), or MMF + NEO (n=11). The following doses were used: AZA, 2 mg/kg per d from days 0 to 13, then 1 mg/kg per d; MMF, 2 g/d starting on day 1; and CsA, either SAND or NEO, 6 mg/kg per d from day 6. At least two serum samples per month were available during the initial 3 mo for each patient. IgG anti-OKT3 antibodies were first evaluated by enzyme-linked immunosorbent assay. Patients were considered sensitized if their serum scored positive at a dilution > or = 1/1000. Peak titers of IgG anti-OKT3 antibodies and the incidence of patients harboring neutralizing anti-idiotypic antibodies were also determined. A first reduction in OKT3 sensitization was seen in patients receiving Neoral instead of Sandimmun (AZA + SAND: 10 of 20 [50%] patients sensitized versus 6 of 31 [19%] in the AZA + NEO group; P=0.03). This was probably related to the achievement of higher mean CsA trough blood levels in the NEO group during the first month (253+/-44 versus 186+/-49 ng/ml in SAND patients). Peak antibody titers and the proportion of patients with anti-idiotypic antibodies were similar in the AZA + SAND and AZA + NEO groups. A further reduction in the sensitization rate was observed with the replacement of AZA by MMF (MMF + NEO: 0% sensitized patients; P=0.0013). It is concluded that the combination of CsA-Neoral and MMF efficiently prevents sensitization against OKT3.

OKT3 monoclonal antibody in pediatric kidney transplant recipients with recurrent and resistant allograft rejection

1987 ◽  
Vol 111 (1) ◽  
pp. 45-50 ◽  
Author(s):  
M.R. Leone ◽  
S.R. Alexander ◽  
J.M. Barry ◽  
K. Henell ◽  
M.B. Funnell ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Kidney Transplant ◽  
Allograft Rejection ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

OKT3 Monoclonal Antibody in Pediatric Kidney Transplant Recipients With Recurrent and Resistant Allograft Rejection

1987 ◽  
Vol 138 (6) ◽  
pp. 1487-1487
Author(s):  
M.R. Leone ◽  
S.R. Alexander ◽  
J.M. Barry ◽  
K. Henell ◽  
M.B. Funnell ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Kidney Transplant ◽  
Allograft Rejection ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Monoclonal antibody OKT3 therapy in pediatric kidney transplant recipients

1990 ◽  
Vol 116 (5) ◽  
pp. S86-S91 ◽  
Author(s):  
Michael R. Leone ◽  
John M. Barry ◽  
Steven R. Alexander ◽  
Tyrone Melvin ◽  
Jane Striegel ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Kidney Transplant ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Okt3 Therapy

scholarly journals Monoclonal Antibody Therapy for SARS-CoV-2 Infection in Kidney Transplant Recipients

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Guillaume Fernandes ◽  
Arnaud Devresse ◽  
Anais Scohy ◽  
Jean Cyr Yombi ◽  
Leila Belkhir ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Kidney Transplant ◽  
Antibody Therapy ◽  
Monoclonal Antibody Therapy ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients
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