Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques

2021 ◽  
Author(s):  
Melanie L. Graham ◽  
Sabarinathan Ramachandran ◽  
Amar Singh ◽  
Meghan E. G. Moore ◽  
E. Brian Flanagan ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Porcine Islet ◽  
Cynomolgus Macaques

Author response for "Overexpression of GILZ in macrophages limits systemic inflammation while increasing bacterial clearance in sepsis in mice"

2019 ◽  
Author(s):  
Mehdi Ellouze ◽  
Lola Vigouroux ◽  
Colas Tcherakian ◽  
Paul‐Louis Woerther ◽  
Aurélie Guguin ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Author Response ◽  
Bacterial Clearance

RELATION OF THE MARKERS OF MYOCARDIAL DYSFUNCTION AND SYSTEMIC INFLAMMATION WITH STRUCTURAL AND FUNCTIONAL PARAMETERS OF THE LUNGS IN MYOCARDIAL INFARCTION PATIENTS

2018 ◽  
Vol 17 (2) ◽  
pp. 24-28
Author(s):  
O. M. Polikutina ◽  
Y. S. Slepynina ◽  
E. D. Bazdyrev ◽  
V. N. Karetnikova ◽  
O. L. Barbarach
Keyword(s):  
Myocardial Infarction ◽  
Systemic Inflammation ◽  
Myocardial Dysfunction ◽  
Control Group ◽  
Chronic Obstructive ◽  
Lung Pathology ◽  
Functional Changes ◽  
Functional Parameters ◽  
Lung Capacity ◽  
Copd Patients

Aim. To evaluate the structural and functional changes in the lungs of ST elevation myocardial infarction (STEMI) patients with absence or presence of chronic obstructive lung disease (COPD), and the relation with myocardial dysfunction and systemic inflammation.Material and methods. Totally, 189 STEMI patients included: group 1 — STEMI with COPD of moderate and mild grade, 2 — STEMI with no lung pathology. Groups were comparable by clinical and anamnestic parameters. Assessment of lung function and blood collection were done at 10­12 day of STEMI. For comparison of the parameters representing structural and functional changes in the lungs and comparison of C­reactive protein (CRP), N­terminal pro­brain natriuretic peptide (NT­proBNP) concentration, a control group was formed with no pulmonary pathology, comparable by age and sex with the STEMI patients.Results. In COPD patients, higher values revealed of the parameters representing the part of residual volumes in pulmonary structure. Higher residual volume (RV) was found also in STEMI and no COPD comparing to controls, however the relation RV/TLC (total lung capacity) was not higher than normal range. In both groups there were lower values of diffusion lung capacity (DLCO) comparing to controls. The lowest DLCO found in COPD patients. Concentration of NT­proBNP (H=41,6; p<0,001) and CRP (H=38,6; p<0,001) in COPD was significantly higher in STEMI with no COPD patients than in controls. The negative correlations found for NT­proBNP and CRP with forced expiratory volume 1 sec, FEV/FVC1, DLCO, and positive — with the values of thoracic volume, RV/TLC.Conclusion. In STEMI patients the increase revealed of residual lung volumes. Mostly the level of residual volumes is high in STEMI and COPD patients. There are associations of NT­proBNP and CRP with structural and functional parameters of the lungs regardless of COPD.

1856-P: Hepatic Insulin Clearance Is Not Driven by Liver Fat but by Systemic Inflammation: A Mendelian Randomization Study

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1856-P
Author(s):  
APOSTOLIA LAMPRINOU ◽  
JÜRGEN MACHANN ◽  
FRITZ SCHICK ◽  
SABINE S. ECKSTEIN ◽  
CHIARA DALLA MAN ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Mendelian Randomization ◽  
Insulin Clearance ◽  
Liver Fat ◽  
Hepatic Insulin Clearance

2289-PUB: Comparison of GalT-KO Porcine Islet Xenograft Survival between Microcapsule against Hypoxia and Microcapsule against Fibrosis in Diabetic Mice Model

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2289-PUB
Author(s):  
EUN YOUNG LEE ◽  
YEOREE YANG ◽  
YUNJUNG CHO ◽  
SEUNG-HWAN LEE ◽  
JAE-HYOUNG CHO ◽  
...  
Keyword(s):  
Diabetic Mice ◽  
Mice Model ◽  
Porcine Islet
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