Immediate and Catastrophic Antibody-Mediated Rejection in a Lung Transplant Recipient With Anti-Angiotensin II Receptor Type 1 and Anti-Endothelin-1 Receptor Type A Antibodies

2016 ◽  
Vol 17 (2) ◽  
pp. 557-564 ◽  
Author(s):  
E. Cozzi ◽  
F. Calabrese ◽  
M. Schiavon ◽  
P. Feltracco ◽  
M. Seveso ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Transplant Recipient ◽  
Lung Transplant ◽  
Type A ◽  
Receptor Type ◽  
Lung Transplant Recipient ◽  
Angiotensin Ii Receptor ◽  
Endothelin 1 ◽  
Antibody Mediated Rejection

Functional autoantibodies against Endothelin-1 receptor type A and Angiotensin II receptor type 1 in patients with preeclampsia

2018 ◽  
Vol 14 ◽  
pp. 189-194 ◽  
Author(s):  
Sara Buttrup Larsen ◽  
Gerd Wallukat ◽  
Ingolf Schimke ◽  
Anna Sandager ◽  
Therese Tvilum Christensen ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Type A ◽  
Receptor Type ◽  
Angiotensin Ii Receptor ◽  
Endothelin 1

scholarly journals Antibodies against Angiotensin II Type 1 and Endothelin 1 Type A Receptors in Cardiovascular Pathologies

2022 ◽  
Vol 23 (2) ◽  
pp. 927
Author(s):  
Giovanni Civieri ◽  
Laura Iop ◽  
Francesco Tona
Keyword(s):  
Angiotensin Ii ◽  
Type A ◽  
Receptor Type ◽  
Current Evidence ◽  
Circulatory Support ◽  
Angiotensin Ii Receptor ◽  
Endothelin 1 ◽  
Coronary Syndromes ◽  
Cardiovascular Pathologies

Angiotensin II receptor type 1 (AT1R) and endothelin-1 receptor type A (ETAR) are G-protein-coupled receptors (GPCRs) expressed on the surface of a great variety of cells: immune cells, vascular smooth cells, endothelial cells, and fibroblasts express ETAR and AT1R, which are activated by endothelin 1 (ET1) and angiotensin II (AngII), respectively. Certain autoantibodies are specific for these receptors and can regulate their function, thus being known as functional autoantibodies. The function of these antibodies is similar to that of natural ligands, and it involves not only vasoconstriction, but also the secretion of proinflammatory cytokines (such as interleukin-6 (IL6), IL8 and TNF-α), collagen production by fibroblasts, and reactive oxygen species (ROS) release by fibroblasts and neutrophils. The role of autoantibodies against AT1R and ETAR (AT1R-AAs and ETAR-AAs, respectively) is well described in the pathogenesis of many medical conditions (e.g., systemic sclerosis (SSc) and SSc-associated pulmonary hypertension, cystic fibrosis, and allograft dysfunction), but their implications in cardiovascular diseases are still unclear. This review summarizes the current evidence regarding the effects of AT1R-AAs and ETAR-AAs in cardiovascular pathologies, highlighting their roles in heart transplantation and mechanical circulatory support, preeclampsia, and acute coronary syndromes.

scholarly journals Antibodies Against Angiotensin II Receptor Type 1 and Endothelin A Receptor Are Associated With an Unfavorable COVID19 Disease Course

2021 ◽  
Vol 12 ◽  
Author(s):  
Jelle Miedema ◽  
Marco Schreurs ◽  
Simone van der Sar – van der Brugge ◽  
Marthe Paats ◽  
Sara Baart ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Transplant Rejection ◽  
Receptor Type ◽  
Disease Course ◽  
Angiotensin Ii Receptor ◽  
Laboratory Findings ◽  
Antibody Mediated Rejection ◽  
Lung Histopathology ◽  
Antibody Titers

BackgroundLung histopathology demonstrates vasculopathy in a subset of deceased COVID19 patients, which resembles histopathology observed in antibody-mediated lung transplant rejection. Autoantibodies against angiotensin II type 1 receptor (AT1R) and Endothelin receptor Type A (ETAR) have been demonstrated in antibody-mediated rejection and may also be associated with severe COVID19 infection. Objective To assess AT1R and ETAR auto-antibodies in COVID19 patients and controls, and explore their association with disease course.Methods65 hospitalized patients with COVID19 infection were included. Clinical and laboratory findings were retrospectively assessed. Patients with unfavorable disease course, admitted at the intensive care unit and/or deceased during hospital admission (n=33) were compared to admitted COVID19 patients with favorable disease course (n=32). The presence of antinuclear antibodies (ANA) and auto-antibodies against AT1R or ETAR in peripheral blood were compared between COVID19 with unfavorable and favorable disease course and age matched controls (n=20).ResultsThe presence of ANA was not significantly different between COVID19 patients with unfavorable (n=7/33; 21%) and favorable disease course (n=6/32; 19%) (p= 0.804) and controls (n=3/20; 15%). Auto-antibodies against AT1R were significantly increased in unfavorable disease course (median 14.59 U/mL, IQR 11.28 – 19.89) compared to favorable disease course (median 10.67 U/mL, IQR 8.55 – 13.0, p< 0.01). ETAR antibody titers were also significantly increased in unfavorable disease course (median 7.21, IQR 5.0 – 10.45) as compared to favorable disease course (median 4.0, IQR 3.0 – 6.0, p <0.05).ConclusionAuto-antibodies against AT1R and ETAR are significantly increased in COVID19 patients with an unfavorable disease course.

Angiotensin II Receptor Type 1 mRNA is Upregulated in Atria of Patients with End-stage Heart Failure

1997 ◽  
Vol 29 (8) ◽  
pp. 2299-2304 ◽  
Author(s):  
Raffi R Kaprielian ◽  
Emmanuel Dupont ◽  
Sassan Hafizi ◽  
Philip A Poole-Wilson ◽  
Asghar Khaghani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Angiotensin Ii ◽  
Receptor Type ◽  
Angiotensin Ii Receptor ◽  
End Stage Heart Failure ◽  
End Stage

Identification of Regions in the Human Angiotensin II Receptor Type 1 Responsible for Gi and Gq Coupling by Mutagenesis Study

1996 ◽  
Vol 218 (1) ◽  
pp. 383-389 ◽  
Author(s):  
Takeshi Shibata ◽  
Chiharu Suzuki ◽  
Junji Ohnishi ◽  
Kazuo Murakami ◽  
Hitoshi Miyazaki
Keyword(s):  
Angiotensin Ii ◽  
Receptor Type ◽  
Angiotensin Ii Receptor ◽  
Mutagenesis Study
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