scholarly journals EP02.01: Autoantibodies against the Endothelin-1 receptor type A and the Angiotensin II receptor type 1 in patients with pregnancy induced hypertension and pre-eclampsia

2018 ◽  
Vol 52 ◽  
pp. 196-196
Author(s):  
N. Tørring ◽  
S. Larsen ◽  
G. Wallukat ◽  
I. Schimke ◽  
A. Sandager ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Type A ◽  
Receptor Type ◽  
Pregnancy Induced Hypertension ◽  
Angiotensin Ii Receptor ◽  
Endothelin 1 ◽  
Induced Hypertension

Functional autoantibodies against Endothelin-1 receptor type A and Angiotensin II receptor type 1 in patients with preeclampsia

2018 ◽  
Vol 14 ◽  
pp. 189-194 ◽  
Author(s):  
Sara Buttrup Larsen ◽  
Gerd Wallukat ◽  
Ingolf Schimke ◽  
Anna Sandager ◽  
Therese Tvilum Christensen ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Type A ◽  
Receptor Type ◽  
Angiotensin Ii Receptor ◽  
Endothelin 1

scholarly journals Antibodies against Angiotensin II Type 1 and Endothelin 1 Type A Receptors in Cardiovascular Pathologies

2022 ◽  
Vol 23 (2) ◽  
pp. 927
Author(s):  
Giovanni Civieri ◽  
Laura Iop ◽  
Francesco Tona
Keyword(s):  
Angiotensin Ii ◽  
Type A ◽  
Receptor Type ◽  
Current Evidence ◽  
Circulatory Support ◽  
Angiotensin Ii Receptor ◽  
Endothelin 1 ◽  
Coronary Syndromes ◽  
Cardiovascular Pathologies

Angiotensin II receptor type 1 (AT1R) and endothelin-1 receptor type A (ETAR) are G-protein-coupled receptors (GPCRs) expressed on the surface of a great variety of cells: immune cells, vascular smooth cells, endothelial cells, and fibroblasts express ETAR and AT1R, which are activated by endothelin 1 (ET1) and angiotensin II (AngII), respectively. Certain autoantibodies are specific for these receptors and can regulate their function, thus being known as functional autoantibodies. The function of these antibodies is similar to that of natural ligands, and it involves not only vasoconstriction, but also the secretion of proinflammatory cytokines (such as interleukin-6 (IL6), IL8 and TNF-α), collagen production by fibroblasts, and reactive oxygen species (ROS) release by fibroblasts and neutrophils. The role of autoantibodies against AT1R and ETAR (AT1R-AAs and ETAR-AAs, respectively) is well described in the pathogenesis of many medical conditions (e.g., systemic sclerosis (SSc) and SSc-associated pulmonary hypertension, cystic fibrosis, and allograft dysfunction), but their implications in cardiovascular diseases are still unclear. This review summarizes the current evidence regarding the effects of AT1R-AAs and ETAR-AAs in cardiovascular pathologies, highlighting their roles in heart transplantation and mechanical circulatory support, preeclampsia, and acute coronary syndromes.

Angiotensin II Receptor Type 1 mRNA is Upregulated in Atria of Patients with End-stage Heart Failure

1997 ◽  
Vol 29 (8) ◽  
pp. 2299-2304 ◽  
Author(s):  
Raffi R Kaprielian ◽  
Emmanuel Dupont ◽  
Sassan Hafizi ◽  
Philip A Poole-Wilson ◽  
Asghar Khaghani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Angiotensin Ii ◽  
Receptor Type ◽  
Angiotensin Ii Receptor ◽  
End Stage Heart Failure ◽  
End Stage

Identification of Regions in the Human Angiotensin II Receptor Type 1 Responsible for Gi and Gq Coupling by Mutagenesis Study

1996 ◽  
Vol 218 (1) ◽  
pp. 383-389 ◽  
Author(s):  
Takeshi Shibata ◽  
Chiharu Suzuki ◽  
Junji Ohnishi ◽  
Kazuo Murakami ◽  
Hitoshi Miyazaki
Keyword(s):  
Angiotensin Ii ◽  
Receptor Type ◽  
Angiotensin Ii Receptor ◽  
Mutagenesis Study
Sign in / Sign up

Export Citation Format

Share Document