scholarly journals Factors Related to the Development of CMV-Specific CD8+ T cell Response in CMV-Seropositive Solid Organ Transplant Candidates

2015 ◽  
Vol 15 (3) ◽  
pp. 715-722 ◽  
Author(s):  
S. Cantisán ◽  
C. Rodelo-Haad ◽  
A. Páez-Vega ◽  
A. Nieto ◽  
J. M. Vaquero ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Organ Transplant ◽  
Cd8 T Cell ◽  
Solid Organ Transplant ◽  
T Cell Response ◽  
Solid Organ ◽  
Transplant Candidates

Cell-Mediated Immune Responses After Influenza Vaccination of Solid Organ Transplant Recipients: Secondary Outcomes Analyses of a Randomized Controlled Trial

2019 ◽  
Vol 221 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Arnaud G L’huillier ◽  
Victor H Ferreira ◽  
Cedric Hirzel ◽  
Yoichiro Natori ◽  
Jaclyn Slomovic ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Influenza A ◽  
Organ Transplant ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Cell Responses ◽  
Influenza A H1n1

Abstract Background Despite annual immunization, solid organ transplant (SOT) patients remain at increased risk for severe influenza infection because of suboptimal vaccine immunogenicity. We aimed to compare the CD4+ and CD8+ T-cell responses of the high-dose (HD) and the standard-dose (SD) trivalent inactivated vaccine. Methods We collected peripheral blood mononuclear cells pre- and postimmunization from 60 patients enrolled in a randomized trial of HD versus SD vaccine (30 HD; 30 SD) during the 2016–2017 influenza season. Results The HD vaccine elicited significantly greater monofunctional and polyfunctional CD4+ and CD8+ T-cell responses against influenza A/H1N1, A/H3N2, and B. For example, median vaccine-elicited influenza-specific polyfunctional CD4+ T cells were higher in recipients of the HD than SD vaccine after stimulation with influenza A/H1N1 (1193 vs 0 per 106 CD4+ T cells; P = .003), A/H3N2 (1154 vs 51; P = .008), and B (1102 vs 0; P = .001). Likewise, vaccine-elicited influenza-specific polyfunctional CD8+ T cells were higher in recipients of the HD than SD vaccine after stimulation with influenza B (367 vs 0; P = .002). Conclusions Our study provides novel evidence that HD vaccine elicits greater cellular responses compared with the SD vaccine in SOT recipients, which provides support to preferentially consider use of HD vaccination in the SOT setting.

EBV-specific memory CD8+ T cell phenotype and function in stable solid organ transplant patients

2005 ◽  
Vol 14 (2) ◽  
pp. 109-116 ◽  
Author(s):  
Camila Macedo ◽  
Albert Donnenberg ◽  
Iulia Popescu ◽  
Jorge Reyes ◽  
Kareem Abu-Elmagd ◽  
...  
Keyword(s):  
T Cell ◽  
Organ Transplant ◽  
Cd8 T Cell ◽  
Solid Organ Transplant ◽  
Cell Phenotype ◽  
Solid Organ ◽  
Transplant Patients ◽  
Specific Memory ◽  
Memory Cd8 T Cell ◽  
And Function

scholarly journals Symptomatic and Asymptomatic Viral Recrudescence in Solid-Organ Transplant Recipients and Its Relationship with the Antigen-Specific CD8+ T-Cell Response

2007 ◽  
Vol 81 (20) ◽  
pp. 11538-11542 ◽  
Author(s):  
Tania Crough ◽  
Chrysa Fazou ◽  
Julissa Weiss ◽  
Scott Campbell ◽  
Miles P. Davenport ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Response ◽  
Ex Vivo ◽  
Organ Transplant ◽  
Hla Class I ◽  
T Cell Response ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Ifn Γ

ABSTRACT Using ex vivo antigen-specific T-cell analysis, we found that symptomatic cytomegalovirus recrudescence in transplant recipients was coincident with reduced expression of gamma interferon (IFN-γ) by virus-specific CD8+ T cells and an up-regulation of CD38 expression on these T cells, although there was no significant change in the absolute number of virus-specific cells (as assessed by major histocompatibility complex-peptide multimers). In contrast, HLA class I-matched transplant patients with asymptomatic viral recrudescence showed increased expansion of antigen-specific T cells and highly stable IFN-γ expression by epitope-specific T cells. These studies suggest that a strong functional T-cell response plays a crucial role in defining the clinical outcome of acute viral recrudescence.

scholarly journals Immune Response to BNT162b2 in Solid Organ Transplant Recipients: Negative Impact of Mycophenolate and High Responsiveness of SARS-CoV-2 Recovered Subjects against Delta Variant

2021 ◽  
Vol 9 (12) ◽  
pp. 2622
Author(s):  
Irene Cassaniti ◽  
Federica Bergami ◽  
Francesca Arena ◽  
Jose Camilla Sammartino ◽  
Alessandro Ferrari ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Negative Impact ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
T Cell Response ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

The immunogenicity of severe acute respiratory syndrome 2 virus (SARS-CoV-2) vaccines in immunocompromised patients remains to be further explored. Here, we evaluated the immunogenicity elicited by complete vaccination with BNT162b2 vaccine in solid organ transplant recipients (SOTRs). A cohort of 110 SOTRs from Northern Italy were vaccinated with two doses of BNT162b2 mRNA vaccine and prospectively monitored at baseline and after 42 days. Both SARS-CoV-2 naïve and recovered subjects were included. Humoral response elicited by vaccination, including SARS-CoV-2 neutralizing antibodies (SARS-CoV-2 NT Abs), was evaluated; additionally, ex-vivo ELISpot assay was performed for the quantification of Spike-specific T-cell response. Results were compared with those obtained in a cohort of healthy subjects. In a subset of patients, humoral and T-cell responses against delta variant were also evaluated. Less than 20% of transplanted subjects developed a positive humoral and cell-mediated response after complete vaccination schedule. Overall, median levels of immune response elicited by vaccination were significantly lower with respect to controls in SARS-CoV-2 naïve transplant, but not in SARS-CoV-2 recovered transplanted patients. Additionally, a significant impairment of both humoral and cell-mediated response was observed in mycophenolate-treated patients. Positive delta-SARS-CoV-2 NT Abs levels were detected in almost all the SARS-CoV-2 recovered subjects but not in previously uninfected patients. Our study supports previous observations of a low level of seroconversion after vaccination in transplanted patients.

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