Quantitative analysis of EBV-specific CD4/CD8 T cell numbers, absolute CD4/CD8 T cell numbers and EBV load in solid organ transplant recipients with PLTD

2007 ◽  
Vol 17 (3) ◽  
pp. 203-210 ◽  
Author(s):  
Kathrin Sebelin-Wulf ◽  
Tuan D. Nguyen ◽  
Stephan Oertel ◽  
Matthias Papp-Vary ◽  
Ralf Ulrich Trappe ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
T Cell ◽  
Organ Transplant ◽  
Cd8 T Cell ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Cell Numbers ◽  
Solid Organ Transplant Recipients

P-glycoprotein (P-gp) Is Upregulated in Peripheral T-Cell Subsets from Solid Organ Transplant Recipients

2001 ◽  
Vol 41 (12) ◽  
pp. 1271-1279 ◽  
Author(s):  
Ms. Vera S. Donnenberg ◽  
Gilbert J. Burckart ◽  
Bartley P. Griffith ◽  
Ashok B. Jain ◽  
Adriana Zeevi ◽  
...  
Keyword(s):  
T Cell ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
T Cell Subsets ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Glycoprotein P ◽  
Organ Transplant Recipients ◽  
P Glycoprotein ◽  
Solid Organ Transplant Recipients

scholarly journals Immune Response to BNT162b2 in Solid Organ Transplant Recipients: Negative Impact of Mycophenolate and High Responsiveness of SARS-CoV-2 Recovered Subjects against Delta Variant

2021 ◽  
Vol 9 (12) ◽  
pp. 2622
Author(s):  
Irene Cassaniti ◽  
Federica Bergami ◽  
Francesca Arena ◽  
Jose Camilla Sammartino ◽  
Alessandro Ferrari ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Negative Impact ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
T Cell Response ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Solid Organ Transplant Recipients

The immunogenicity of severe acute respiratory syndrome 2 virus (SARS-CoV-2) vaccines in immunocompromised patients remains to be further explored. Here, we evaluated the immunogenicity elicited by complete vaccination with BNT162b2 vaccine in solid organ transplant recipients (SOTRs). A cohort of 110 SOTRs from Northern Italy were vaccinated with two doses of BNT162b2 mRNA vaccine and prospectively monitored at baseline and after 42 days. Both SARS-CoV-2 naïve and recovered subjects were included. Humoral response elicited by vaccination, including SARS-CoV-2 neutralizing antibodies (SARS-CoV-2 NT Abs), was evaluated; additionally, ex-vivo ELISpot assay was performed for the quantification of Spike-specific T-cell response. Results were compared with those obtained in a cohort of healthy subjects. In a subset of patients, humoral and T-cell responses against delta variant were also evaluated. Less than 20% of transplanted subjects developed a positive humoral and cell-mediated response after complete vaccination schedule. Overall, median levels of immune response elicited by vaccination were significantly lower with respect to controls in SARS-CoV-2 naïve transplant, but not in SARS-CoV-2 recovered transplanted patients. Additionally, a significant impairment of both humoral and cell-mediated response was observed in mycophenolate-treated patients. Positive delta-SARS-CoV-2 NT Abs levels were detected in almost all the SARS-CoV-2 recovered subjects but not in previously uninfected patients. Our study supports previous observations of a low level of seroconversion after vaccination in transplanted patients.

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