Preventing Early‐Onset Group B Streptococcus neonatal infection and reducing antibiotic exposure using a rapid PCR test in term prelabour rupture of membranes

2020 ◽  
Vol 60 (5) ◽  
pp. 753-759
Author(s):  
Mandy Wang ◽  
Caitlin Keighley ◽  
Matthew Watts ◽  
Martin Plymoth ◽  
Therese M. McGee
Keyword(s):  
Early Onset ◽  
Group B Streptococcus ◽  
Neonatal Infection ◽  
Antibiotic Exposure ◽  
Rapid Pcr ◽  
Group B ◽  
Onset Group ◽  
Early Onset Group ◽  
Pcr Test

Early-Onset Pneumococcal Sepsis in Newborn Infants

PEDIATRICS ◽  
1977 ◽  
Vol 60 (3) ◽  
pp. 352-355
Author(s):  
Robert Bortolussi ◽  
Theodore R. Thompson ◽  
Patricia Ferrieri
Keyword(s):  
Early Onset ◽  
Streptococcal Infection ◽  
Group B Streptococcus ◽  
Newborn Infants ◽  
Clinical Signs ◽  
Pneumococcal Sepsis ◽  
Life Threatening ◽  
Group B ◽  
Onset Group ◽  
Early Onset Group

Five infants with pneumococcal sepsis presented with respiratory distress and clinical signs of infection in the first day of life. Although there was no apparent epidemiological relationship among the patients, four of the five were seen within a 12-month period. Pneumonia, prolonged rupture of fetal membranes, and prematurity were features in these patients. Three infants died, two within 12 hours of diagnosis. Streptococcus pneumoniae was isolated from the vagina of three of the mothers; in two, the serotype was identical to that recovered from their infants. Clinical features of neonatal pneumococcal sepsis are similar to those of early-onset group B streptococcal infection. Like the group B Streptococcus, S. pneumoniae acquired from the maternal vagina is a potential life-threatening pathogen in the newborn period.

Intrapartum Evidence of Early-Onset Group B Streptococcus

2012 ◽  
Vol 119 (3) ◽  
pp. 626-629 ◽  
Author(s):  
Carmen M. Tudela ◽  
Robert D. Stewart ◽  
Scott W. Roberts ◽  
George D. Wendel ◽  
Irene A. Stafford ◽  
...  
Keyword(s):  
Early Onset ◽  
Group B Streptococcus ◽  
Group B ◽  
Onset Group ◽  
Early Onset Group

scholarly journals Early onset group B streptococcal neonatal infection in Oxford 1985-96

1998 ◽  
Vol 79 (2) ◽  
pp. F148-F149 ◽  
Author(s):  
L. M Moses ◽  
P T Heath ◽  
A R Wilkinson ◽  
H E Jeffery ◽  
D Isaacs
Keyword(s):  
Early Onset ◽  
Neonatal Infection ◽  
Group B ◽  
Onset Group ◽  
Early Onset Group

scholarly journals Effect of Resident Physician Education Regarding Selective Chemoprophylaxis for the Prevention of Early Onset Group B Streptococcal Sepsis: An Outcome Study

1994 ◽  
Vol 1 (5) ◽  
pp. 210-215
Author(s):  
Jeffrey S. Greenspoon ◽  
Doron J. D. Rosen ◽  
Anita P. Sumen
Keyword(s):  
Risk Factors ◽  
Education Program ◽  
Early Onset ◽  
Neonatal Infection ◽  
Physician Education ◽  
Streptococcal Sepsis ◽  
The Difference ◽  
Group B ◽  
Onset Group ◽  
Early Onset Group

Objective:The aim of this study was to evaluate the effect of a voluntary protocol for selective intrapartum chemoprophylaxis on the incidence of early onset group B streptococcal sepsis (GBS EOS).Methods:Cases of GBS EOS were defined as a positive GBS culture from a normally sterile fluid obtained during the first 7 days of life. All cases of GBS EOS at an urban, university-affiliated community hospital were reviewed during 2 time periods. The 2-year period before instituting a resident education program to promote selective chemoprophylaxis (1988–89) was retrospectively reviewed; the 2-year period after the education program was introduced (1990–91) was prospectively recorded. The outcome measure was the incidence of GBS EOS.Results:The rate of GBS EOS was 7/14,335 deliveries (0.05%) before and 9/13,999 (0.064%) after the introduction of the education program (observed difference between proportions 0.016%, 95% confidence interval [CI] for the difference between the proportions –0.071% to 0.04%,P= not significant [NS]). The rate of GBS EOS in preterm infants was 5/1,331 (0.376%) before and 3/1,297 (0.23%) afterward (observed difference between proportions 0.14%, 95% CI –0.28% to 0.56%,P= NS). The incidence of GBS EOS did not decrease during the latter period due to failure of antepartum cultures to predict intrapartum GBS colonization (2 cases); non-compliance with voluntary recommendations to administer chemoprophylaxis (2 cases); failure of chemoprophylaxis or therapy for intraamniotic infection to prevent neonatal infection (3 cases); and occurrence of GBS EOS in infants without risk factors (2 cases).Conclusions:An education program for resident physicians regarding chemoprophylaxis for GBS EOS did not significantly reduce the absolute incidence of disease. Alternative strategies are needed that redress the causes of failure inherent in the current guidelines. Some cases of GBS EOS are not preventable because the parturient does not have risk factors that indicate chemoprophylaxis.

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