Lymphocyte immunotherapy in recurrent miscarriage and recurrent implantation failure

2021 ◽  
Author(s):  
Marcelo Borges Cavalcante ◽  
Manoel Sarno ◽  
Ricardo Barini
Keyword(s):  
Recurrent Miscarriage ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Lymphocyte Immunotherapy

The Impact of New Immunological Therapeutic Strategies on Recurrent Miscarriage and Recurrent Implantation Failure

2021 ◽  
Author(s):  
Forough Parhizkar ◽  
Roza Motavalli-Khiavi ◽  
Leili Aghebati-Maleki ◽  
Zahra Parhizkar ◽  
Ramin Pourakbari ◽  
...  
Keyword(s):  
Recurrent Miscarriage ◽  
Therapeutic Strategies ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
The Impact

scholarly journals HOXA-10 and E-cadherin expression in the endometrium of women with recurrent implantation failure and recurrent miscarriage

2017 ◽  
Vol 107 (1) ◽  
pp. 136-143.e2 ◽  
Author(s):  
Yihua Yang ◽  
Xiaoyan Chen ◽  
Sotirios H. Saravelos ◽  
Yingyu Liu ◽  
Jin Huang ◽  
...  
Keyword(s):  
Recurrent Miscarriage ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
E Cadherin

scholarly journals Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage

2015 ◽  
Vol 17 (4) ◽  
pp. 681 ◽  
Author(s):  
AllanA Pacey ◽  
Carol Coughlan ◽  
Helen Clarke ◽  
Rachel Cutting ◽  
Jane Saxton ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Recurrent Miscarriage ◽  
Sperm Dna Fragmentation ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Sperm Dna

scholarly journals The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1425
Author(s):  
Konstantinos Sfakianoudis ◽  
Anna Rapani ◽  
Sokratis Grigoriadis ◽  
Agni Pantou ◽  
Evangelos Maziotis ◽  
...  
Keyword(s):  
Natural Killer ◽  
Recurrent Miscarriage ◽  
Current Evidence ◽  
Routine Practice ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Causative Relationship ◽  
Unk Cells ◽  
Uterine Natural Killer

Uterine natural killer (uNK) cells constitute a unique uterine leucocyte subpopulation facilitating implantation and maintaining pregnancy. Herein, we critically analyze current evidence regarding the role of uNK cells in the events entailed in recurrent implantation failure (RIF) and recurrent miscarriages (RM). Data suggest an association between RIF and RM with abnormally elevated uNK cells’ numbers, as well as with a defective biological activity leading to cytotoxicity. However, other studies do not concur on these associations. Robust data suggesting a definitive causative relationship between uNK cells and RIF and RM is missing. Considering the possibility of uNK cells involvement on RIF and RM pathophysiology, possible treatments including glucocorticoids, intralipids, and intravenous immunoglobulin administration have been proposed towards addressing uNK related RIF and RM. When considering clinical routine practice, this study indicated that solid evidence is required to report on efficiency and safety of these treatments as there are recommendations that clearly advise against their employment. In conclusion, defining a causative relationship between uNK and RIF–RM pathologies certainly merits investigation. Future studies should serve as a prerequisite prior to proposing the use of uNK as a biomarker or prior to targeting uNK cells for therapeutic purposes addressing RIF and RM.

scholarly journals A comparison of transcriptomic profiles in endometrium during window of implantation between women with unexplained recurrent implantation failure and recurrent miscarriage

Reproduction ◽  
2017 ◽  
Vol 153 (6) ◽  
pp. 749-758 ◽  
Author(s):  
Jin Huang ◽  
Hao Qin ◽  
Yihua Yang ◽  
Xiaoyan Chen ◽  
Jiamiao Zhang ◽  
...  
Keyword(s):  
Differentially Expressed Genes ◽  
Recurrent Miscarriage ◽  
Expression Profiles ◽  
Differentially Expressed ◽  
Coagulation Cascade ◽  
Support Vector ◽  
Implantation Failure ◽  
Rna Seq ◽  
Recurrent Implantation Failure ◽  
Altered Expression

The endometrium becomes receptive to the embryo only in the mid-luteal phase, but not in the other stages of the menstrual cycle. Endometrial factors play an important role in implantation. Women with recurrent miscarriage and recurrent implantation failure have both been reported to have altered expression of receptivity markers during the window of implantation. We aimed to compare the gene expression profiles of the endometrium in the window of implantation among women with unexplained recurrent implantation failures (RIF) and unexplained recurrent miscarriages (RM) by RNA sequencing (RNA-Seq). In total 20 patients (9 RIF and 11 RM) were recruited. In addition 4 fertile subjects were included as reference. Endometrium samples were precisely timed on the 7th day after luteal hormone surge (LH + 7). All the 24 endometrium samples were extracted for total RNA. The transcriptome was determined by RNA-Seq in the first 14 RNA samples (5 RIF, 6 RM and 3 fertile). Differentially expressed genes between RM and RIF were validated by quantitative real-time PCR (qPCR) in all 24 RNA samples (9 RIF, 11 RM and 4 fertile). Transcriptomic profiles of RM and RIF, but not control samples, were separated from each other by principle component analysis (PCA) and support vector machine (SVM). Complementary and coagulation cascades pathway was significantly up-regulated in RIF while down-regulated in RM. Differentially expressed genes C3, C4, C4BP, DAF, DF and SERPING1 in complement and coagulation cascade pathway between RM and RIF were further validated by qPCR. This study compared endometrial transcriptome among patients with RIF and RM in the window of implantation; it identified differential molecular pathways in endometrium between RIF and RM, which potentially affect the implantation process.

Unexplained Recurrent Miscarriage and Recurrent Implantation Failure: Is There a Place for Immunomodulation?

2016 ◽  
Vol 76 (1) ◽  
pp. 8-28 ◽  
Author(s):  
Arsène Mekinian ◽  
Jonathan Cohen ◽  
Jaume Alijotas-Reig ◽  
Lionel Carbillon ◽  
Pascale Nicaise-Roland ◽  
...  
Keyword(s):  
Recurrent Miscarriage ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Unexplained Recurrent Miscarriage
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