Unexplained Recurrent Miscarriage and Recurrent Implantation Failure: Is There a Place for Immunomodulation?

2016 ◽  
Vol 76 (1) ◽  
pp. 8-28 ◽  
Author(s):  
Arsène Mekinian ◽  
Jonathan Cohen ◽  
Jaume Alijotas-Reig ◽  
Lionel Carbillon ◽  
Pascale Nicaise-Roland ◽  
...  
Keyword(s):  
Recurrent Miscarriage ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Unexplained Recurrent Miscarriage

The Impact of New Immunological Therapeutic Strategies on Recurrent Miscarriage and Recurrent Implantation Failure

2021 ◽  
Author(s):  
Forough Parhizkar ◽  
Roza Motavalli-Khiavi ◽  
Leili Aghebati-Maleki ◽  
Zahra Parhizkar ◽  
Ramin Pourakbari ◽  
...  
Keyword(s):  
Recurrent Miscarriage ◽  
Therapeutic Strategies ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
The Impact

scholarly journals HOXA-10 and E-cadherin expression in the endometrium of women with recurrent implantation failure and recurrent miscarriage

2017 ◽  
Vol 107 (1) ◽  
pp. 136-143.e2 ◽  
Author(s):  
Yihua Yang ◽  
Xiaoyan Chen ◽  
Sotirios H. Saravelos ◽  
Yingyu Liu ◽  
Jin Huang ◽  
...  
Keyword(s):  
Recurrent Miscarriage ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
E Cadherin

scholarly journals Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage

2015 ◽  
Vol 17 (4) ◽  
pp. 681 ◽  
Author(s):  
AllanA Pacey ◽  
Carol Coughlan ◽  
Helen Clarke ◽  
Rachel Cutting ◽  
Jane Saxton ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Recurrent Miscarriage ◽  
Sperm Dna Fragmentation ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Sperm Dna

scholarly journals The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1425
Author(s):  
Konstantinos Sfakianoudis ◽  
Anna Rapani ◽  
Sokratis Grigoriadis ◽  
Agni Pantou ◽  
Evangelos Maziotis ◽  
...  
Keyword(s):  
Natural Killer ◽  
Recurrent Miscarriage ◽  
Current Evidence ◽  
Routine Practice ◽  
Implantation Failure ◽  
Recurrent Implantation Failure ◽  
Causative Relationship ◽  
Unk Cells ◽  
Uterine Natural Killer

Uterine natural killer (uNK) cells constitute a unique uterine leucocyte subpopulation facilitating implantation and maintaining pregnancy. Herein, we critically analyze current evidence regarding the role of uNK cells in the events entailed in recurrent implantation failure (RIF) and recurrent miscarriages (RM). Data suggest an association between RIF and RM with abnormally elevated uNK cells’ numbers, as well as with a defective biological activity leading to cytotoxicity. However, other studies do not concur on these associations. Robust data suggesting a definitive causative relationship between uNK cells and RIF and RM is missing. Considering the possibility of uNK cells involvement on RIF and RM pathophysiology, possible treatments including glucocorticoids, intralipids, and intravenous immunoglobulin administration have been proposed towards addressing uNK related RIF and RM. When considering clinical routine practice, this study indicated that solid evidence is required to report on efficiency and safety of these treatments as there are recommendations that clearly advise against their employment. In conclusion, defining a causative relationship between uNK and RIF–RM pathologies certainly merits investigation. Future studies should serve as a prerequisite prior to proposing the use of uNK as a biomarker or prior to targeting uNK cells for therapeutic purposes addressing RIF and RM.

Sign in / Sign up

Export Citation Format

Share Document