Diagnosis of chronic endometritis: How many CD138 + cells/HPF in endometrial stroma affect pregnancy outcome of infertile women?

2020 ◽  
Author(s):  
Yuye Li ◽  
Shiru Xu ◽  
Shuyi Yu ◽  
Chunyu Huang ◽  
Shenglai Lin ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Chronic Endometritis ◽  
Endometrial Stroma ◽  
Infertile Women

Endometrial Microbiota in Infertile Women With and Without Chronic Endometritis as Diagnosed Using a Quantitative and Reference Range-Based Method

2020 ◽  
Vol 75 (3) ◽  
pp. 170-171
Author(s):  
Yingyu Liu ◽  
Elaine Yee-Ling Ko ◽  
Karen Ka-Wing Wong ◽  
Xiaoyan Chen ◽  
Wing-Ching Cheung ◽  
...  
Keyword(s):  
Reference Range ◽  
Chronic Endometritis ◽  
Infertile Women

005. PREPARING FERTILE SOIL: THE IMPORTANCE OF ENDOMETRIAL RECEPTIVITY

2009 ◽  
Vol 21 (9) ◽  
pp. 4 ◽  
Author(s):  
L. A. Salamonsen
Keyword(s):  
Menstrual Cycle ◽  
Adhesion Molecules ◽  
Reproductive Technologies ◽  
Endometrial Receptivity ◽  
Present Review ◽  
Altered Expression ◽  
Endometrial Stroma ◽  
Infertile Women ◽  
Glandular Cells ◽  
Secretory Capacity

The human endometrium is receptive for implantation of a blastocyst, for only 4–5 days in each menstrual cycle. Failure of implantation is a major reason for infertility in women, and the inability to achieve endometrial receptivity is responsible for much of the failure of reproductive technologies. Endometrial receptivity requires alterations in the uterine luminal and glandular cells, particularly in terms of their secretory capacity and altered expression of adhesion molecules, along with decidualization of the endometrial stroma, which in women is initiated during the receptive phase, regardless of the presence of a blastocyst. Increased leukocyte numbers are also important. The microenvironments provided by the endometrium during the receptive phase and which support implantation are highly complex and constantly changing. The present review summarizes work from our laboratories and others, regarding these microenvironments, how they impact on receptivity and how they are disturbed in infertile women. Such microenvironments can also be manipulated to provide new contraceptive strategies for women.

scholarly journals Endometrial microbiota in infertile women with and without chronic endometritis as diagnosed using a quantitative and reference range-based method

2019 ◽  
Vol 112 (4) ◽  
pp. 707-717.e1 ◽  
Author(s):  
Yingyu Liu ◽  
Elaine Yee-Ling Ko ◽  
Karen Ka-Wing Wong ◽  
Xiaoyan Chen ◽  
Wing-Ching Cheung ◽  
...  
Keyword(s):  
Reference Range ◽  
Chronic Endometritis ◽  
Infertile Women

Effects of Sperm Immobilizing Antibodies on Pregnancy Outcome in Infertile Women Treated With IVF-ET

1996 ◽  
Vol 36 (2) ◽  
pp. 96-100 ◽  
Author(s):  
Hiroaki Shibahara ◽  
Mizumi Mitsuo ◽  
Yoshikazu Ikeda ◽  
Minoru Shigeta ◽  
Koji Koyama
Keyword(s):  
Pregnancy Outcome ◽  
Infertile Women ◽  
Ivf Et

scholarly journals Using Uterine Biophysical Profile as a Predictor of Endometrial Receptivity and Pregnancy in Stimulated IUI Cycles

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Rawaa Saad Hasan Abunayla ◽  
◽  
Lubna Amer Al-Anbari ◽  
Muayad S, Abood ◽  
Huda A. R. Hussaini ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Assisted Reproductive Technologies ◽  
Intrauterine Insemination ◽  
Reproductive Technologies ◽  
Endometrial Receptivity ◽  
Infertile Women ◽  
Biophysical Profile ◽  
The Mean

Implantation failure and disorders of endometrial receptivity represent an essential cause of infertility; multiple parameters were needed to predict the uterine receptivity understanding that no sole parameter could predict the same. A score was termed as (Uterine Biophysical Profile) could be utilized as a predictor of endometrial receptivity. To evaluate the predictive potential of Uterine biophysical profile of both endometrial receptivity and pregnancy outcome in infertile women undergoing Intrauterine Insemination (IUI). The current cross-sectional study was conducted in the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies in Al Nahrain University, Baghdad, Iraq from the 1st of Oct. 2018 till 1st of May 2019 involving seventy women of infertile couples with the same inclusion and exclusion criteria. Uterine biophysical profile was evaluated using a doppler ultrasound examination and then a score was calculated and correlated to pregnancy outcome. The mean Uterine Artery Pulsatility Index (UAPI) was significantly lower in women with positive pregnancy in comparison to women with negative pregnancy, 2.10±0.19 versus 2.47±0.65, respectively (P=0.032). Moreover, no women with Pulsatility Index (PI) score (0) succeeded to get pregnant and the higher the score, the higher the rate of pregnancy (P=0.006). Furthermore, Spearman correlation showed significant positive correlation between positive pregnancy outcome and UAPI (r=0.365; P=0.002). The mean total score was significantly higher for pregnant women than in women with negative pregnancy, 18.27±1.33 versus 16.35±2.47, respectively (P=0.005). The cutoff value was >17 with an acceptable accuracy level of 74.2. The sensitivity of that cutoff vale was 80 % and the specificity was 65.5%. Uterine artery pulsatility index and total uterine biophysical score are the principal predictors of positive pregnancy outcomes in infertile women undergoing IUI.

scholarly journals Prediction of chronic endometritis using 2D and 3D transvaginal ultrasound examination in infertile women

2021 ◽  
Vol 10 (3) ◽  
pp. 865
Author(s):  
Tamer H. Said
Keyword(s):  
Ultrasound Examination ◽  
Transvaginal Ultrasound ◽  
Uterine Cavity ◽  
Reproductive Age ◽  
University Hospital ◽  
Transvaginal Sonography ◽  
Chronic Endometritis ◽  
Infertile Women ◽  
3D Ultrasonography ◽  
2D And 3D

Background: Chronic endometritis is a pathology of continuous and hidden inflammatory process characterized by the infiltration of plasma cells into the endometrial stroma. Transvaginal bi-dimensional ultrasonography is in need to be evaluated in prediction of chronic endometritis in women with delayed pregnancy or infertility as a non-invasive, cheap, acceptable, and safe tool of diagnosis. Previously, 3D ultrasonography had been described as a novel for diagnosis of chronic endometritis and correlation of the images with hysteroscopic view results. Objectives were to predict the presence of chronic endometritis in infertile women during their reproductive age through examination of the uterine cavity by 2D and 3D transvaginal sonography to elicit proposed ultrasonographic signs of endometritis.Methods: This observational prospective study took place at Shatby university hospital, Alexanderia universtiy and was done on two hundred infertile women. Women were assigned for ultrasonographic evaluation as a part of pre-treatment assessment. Detailed history was taken from all the patients included in the study. General examination and routine laboratory investigations were done according to hospital protocol. All patients were asked to do ultrasound examination immediately postmenstrual and at the time of ovulation. We used 2D transvaginal ultrasound to predict chronic endometritis, we searched for 1) presence of persistent endometrial focal or diffuse thickening postmenstrual, 2) presence of focal echogenic foci in the triple line endometrium during ovulation. The 3D ultrasonography was done as confirmatory examination. Office hysteroscopy as the main method for diagnosis of endometritis was performed to all patients either after menses if the first sign was detected or at the time of ovulation if the second sign was detected.Results: The combination of persistent endometrial shreds and/or endometrial focal thickening or echogenicity can significantly predict presence of endometritis as the sensitivity and specificity of the combination were 94.90 and 81.37, respectively.Conclusions: Bi-dimensional ultrasonography done to infertile women at 2 phases of the menstrual period can predict the presence of chronic endometritis as a subtle cause of infertility and might be an indication for hysteroscopic evaluation for these patients.

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