005. PREPARING FERTILE SOIL: THE IMPORTANCE OF ENDOMETRIAL RECEPTIVITY

2009 ◽  
Vol 21 (9) ◽  
pp. 4 ◽  
Author(s):  
L. A. Salamonsen
Keyword(s):  
Menstrual Cycle ◽  
Adhesion Molecules ◽  
Reproductive Technologies ◽  
Endometrial Receptivity ◽  
Present Review ◽  
Altered Expression ◽  
Endometrial Stroma ◽  
Infertile Women ◽  
Glandular Cells ◽  
Secretory Capacity

The human endometrium is receptive for implantation of a blastocyst, for only 4–5 days in each menstrual cycle. Failure of implantation is a major reason for infertility in women, and the inability to achieve endometrial receptivity is responsible for much of the failure of reproductive technologies. Endometrial receptivity requires alterations in the uterine luminal and glandular cells, particularly in terms of their secretory capacity and altered expression of adhesion molecules, along with decidualization of the endometrial stroma, which in women is initiated during the receptive phase, regardless of the presence of a blastocyst. Increased leukocyte numbers are also important. The microenvironments provided by the endometrium during the receptive phase and which support implantation are highly complex and constantly changing. The present review summarizes work from our laboratories and others, regarding these microenvironments, how they impact on receptivity and how they are disturbed in infertile women. Such microenvironments can also be manipulated to provide new contraceptive strategies for women.

Society for Reproductive Biology Founders' Lecture 2009. Preparing fertile soil: the importance of endometrial receptivity

2009 ◽  
Vol 21 (7) ◽  
pp. 923 ◽  
Author(s):  
Lois A. Salamonsen ◽  
Guiying Nie ◽  
Natalie J. Hannan ◽  
Evdokia Dimitriadis
Keyword(s):  
Reproductive Technologies ◽  
Endometrial Receptivity ◽  
Leukaemia Inhibitory Factor ◽  
Uterine Receptivity ◽  
Comprehensive Overview ◽  
Altered Expression ◽  
Molecular Events ◽  
Glandular Cells ◽  
Interleukin 11 ◽  
Secretory Capacity

The human endometrium is receptive for implantation of a blastocyst for only 4–5 days in each menstrual cycle. Failure of implantation is a major reason for infertility in women and the inability to achieve endometrial receptivity is responsible for much of the failure of reproductive technologies. Endometrial receptivity requires changes in the uterine luminal and glandular cells, particularly in terms of their secretory capacity and altered expression of adhesion molecules. In parallel with these changes, decidualisation (differentiation) of the endometrial stroma is initiated in women during the receptive phase, regardless of the presence of a blastocyst. Increased leucocyte numbers are also important. The microenvironments provided by the endometrium during the receptive phase and that support implantation are highly complex and constantly changing as implantation progresses. The present review provides a comprehensive overview of the cellular and molecular events of human implantation. It also summarises work from our laboratories emphasising the functional importance of proprotein convertase 6, along with key cytokines (interleukin-11, leukaemia inhibitory factor, activin A) and chemokines (including CX3CL1 and CCL14), during implantation. Of particular importance is how these mediators contribute to receptivity and how they are disturbed in infertile women. Factors that are critical for uterine receptivity may also be manipulated to provide new contraceptive strategies for women.

scholarly journals Using Uterine Biophysical Profile as a Predictor of Endometrial Receptivity and Pregnancy in Stimulated IUI Cycles

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Rawaa Saad Hasan Abunayla ◽  
◽  
Lubna Amer Al-Anbari ◽  
Muayad S, Abood ◽  
Huda A. R. Hussaini ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Assisted Reproductive Technologies ◽  
Intrauterine Insemination ◽  
Reproductive Technologies ◽  
Endometrial Receptivity ◽  
Infertile Women ◽  
Biophysical Profile ◽  
The Mean

Implantation failure and disorders of endometrial receptivity represent an essential cause of infertility; multiple parameters were needed to predict the uterine receptivity understanding that no sole parameter could predict the same. A score was termed as (Uterine Biophysical Profile) could be utilized as a predictor of endometrial receptivity. To evaluate the predictive potential of Uterine biophysical profile of both endometrial receptivity and pregnancy outcome in infertile women undergoing Intrauterine Insemination (IUI). The current cross-sectional study was conducted in the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies in Al Nahrain University, Baghdad, Iraq from the 1st of Oct. 2018 till 1st of May 2019 involving seventy women of infertile couples with the same inclusion and exclusion criteria. Uterine biophysical profile was evaluated using a doppler ultrasound examination and then a score was calculated and correlated to pregnancy outcome. The mean Uterine Artery Pulsatility Index (UAPI) was significantly lower in women with positive pregnancy in comparison to women with negative pregnancy, 2.10±0.19 versus 2.47±0.65, respectively (P=0.032). Moreover, no women with Pulsatility Index (PI) score (0) succeeded to get pregnant and the higher the score, the higher the rate of pregnancy (P=0.006). Furthermore, Spearman correlation showed significant positive correlation between positive pregnancy outcome and UAPI (r=0.365; P=0.002). The mean total score was significantly higher for pregnant women than in women with negative pregnancy, 18.27±1.33 versus 16.35±2.47, respectively (P=0.005). The cutoff value was >17 with an acceptable accuracy level of 74.2. The sensitivity of that cutoff vale was 80 % and the specificity was 65.5%. Uterine artery pulsatility index and total uterine biophysical score are the principal predictors of positive pregnancy outcomes in infertile women undergoing IUI.

Uterine Function: From Normal to Polycystic Ovarian Syndrome Alterations

2018 ◽  
Vol 25 (15) ◽  
pp. 1792-1804 ◽  
Author(s):  
Silvana R. Ferreira ◽  
Alicia B. Motta
Keyword(s):  
Endometrial Cancer ◽  
Adhesion Molecules ◽  
Polycystic Ovarian Syndrome ◽  
Cellular Proliferation ◽  
Steroid Receptors ◽  
Reproductive Age ◽  
Present Review ◽  
Implantation Failure ◽  
Uterine Function ◽  
Ovarian Syndrome

Background: The endometrium is one of the most important female reproductive organs. Polycystic ovarian syndrome (PCOS) is a reproductive and endocrine pathology that affect women of reproductive age. PCOS negatively affects the endometrium, leading to implantation failure and proliferative aberrations. Methods: We conducted a search at the http://www.ncbi.nlm.nhi.gov/pubmed/electronic database using the following key words: endometrial steroid receptors, endometrium, uterine function, endometrium and PCOS, implantation window, implantation and PCOS, implantation markers, inflammation, oxidative stress. We selected the articles based on their titles and abstracts, then we analyzed the full text and classified the articles depending on the information provided according to the sections of the present review. Results: The endocrine and metabolic abnormalities displayed in women with PCOS promote complex effects on the endometrium, leading to a low rate of implantation and even infertility. Women with PCOS show alterations in the Hypothalamic-Pituitary- Ovarian axis, which results in constant circulating levels of estrogen, similar to those at the early follicular phase, and a deficiency in the withdrawal of estrogen and progesterone. Besides this deficiency in the withdrawal of estrogen and progesterone, the insulin/ glucose pathway, adhesion molecules, cytokines and the inflammatory cascade, together with the establishment of a pro-oxidative status, lead to an imbalance in the uterine function, which in turn leads to implantation failure or even endometrial cancer. Conclusion: Women with PCOS display a dysregulation of the Hypothalamic-Pituitary- Ovarian axis, which alters the steroid pathway. In addition, the deficiency in the withdrawal of estrogen and progesterone in the endometrium results in abnormal endometrial cellular proliferation. The imbalance in adipose tissue observed in PCOS patients reinforces the increase in circulating hormones. The present review describes the role of hormones, metabolites, cytokines, adhesion molecules and the insulin/glucose pathway related to the uterine endometrium in women with PCOS and their role in implantation failure and development of endometrial cancer.

scholarly journals Altered expression of cell adhesion molecules in uninvolved gut in inflammatory bowel disease

2008 ◽  
Vol 94 (2) ◽  
pp. 341-347 ◽  
Author(s):  
G. M. SCHUERMANN ◽  
A. E. ABER-BISHOP ◽  
P. FACER ◽  
J. C. LEE ◽  
D. S. RAMPTON ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Bowel Disease ◽  
Cell Adhesion Molecules ◽  
Altered Expression ◽  
Inflammatory Bowel

scholarly journals A Two-Cohort RNA-seq Study Reveals Changes in Endometrial and Blood miRNome in Fertile and Infertile Women

Genes ◽  
2018 ◽  
Vol 9 (12) ◽  
pp. 574 ◽  
Author(s):  
Kadri Rekker ◽  
Signe Altmäe ◽  
Marina Suhorutshenko ◽  
Maire Peters ◽  
Juan F. Martinez-Blanch ◽  
...  
Keyword(s):  
Embryo Implantation ◽  
Endometrial Receptivity ◽  
Small Rna Sequencing ◽  
Rna Seq ◽  
Recurrent Implantation Failure ◽  
Secretory Phase ◽  
Blood Samples ◽  
Infertile Women ◽  
Secretory Endometrium ◽  
Fertile Women

The endometrium undergoes extensive changes to prepare for embryo implantation and microRNAs (miRNAs) have been described as playing a significant role in the regulation of endometrial receptivity. However, there is no consensus about the miRNAs involved in mid-secretory endometrial functions. We analysed the complete endometrial miRNome from early secretory (pre-receptive) and mid-secretory (receptive) phases from fertile women and from patients with recurrent implantation failure (RIF) to reveal differentially expressed (DE) miRNAs in the mid-secretory endometrium. Furthermore, we investigated whether the overall changes during early to mid-secretory phase transition and with RIF condition could be reflected in blood miRNA profiles. In total, 116 endometrial and 114 matched blood samples collected from two different population cohorts were subjected to small RNA sequencing. Among fertile women, 91 DE miRNAs were identified in the mid-secretory vs. early secretory endometrium, while no differences were found in the corresponding blood samples. The comparison of mid-secretory phase samples between fertile and infertile women revealed 21 DE miRNAs from the endometrium and one from blood samples. Among discovered novel miRNAs, chr2_4401 was validated and showed up-regulation in the mid-secretory endometrium. Besides novel findings, we confirmed the involvement of miR-30 and miR-200 family members in mid-secretory endometrial functions.

scholarly journals Synergism of Hypothyroidism and Hyperprolactinemia to impact on efficiency of menstrual cycle and ovulatory status

2017 ◽  
Vol 1 (28) ◽  
pp. 661-670
Author(s):  
NASSER NAFAA ABRAHEM ◽  
SAAD HASSAN DREIJ ◽  
Mahdi Saber Al-Deresawi
Keyword(s):  
Thyroid Hormone ◽  
Menstrual Cycle ◽  
Teaching Hospital ◽  
Infertile Women ◽  
Menstrual Disturbance ◽  
Menstrual Irregularities ◽  
Relationship Of ◽  
The Relationship ◽  
Hormonal Assay

This study aimed to determine the relationship of  thyroid hormone disturbance and prolactin over production to impact on the menstrual irregularities anovulation .This  study were carried out in Al-Karama teaching hospital and  included (47) primary infertile women, (30 ) of them were with hypothyroidism , the patients aged between (18-40). This study extended from February to June  2017. The hormonal assay of TSH, FT3, FT4 ,FSH , LH and PRL that revealed  :- There were high  significantly (p < 0.01) increased in TSH concentrations , significantly (p < 0.05) decreased in levels of FT3 and  FT4.Gonadotropins hormones recorded significantly ( p <0.05) decreased in levels of FSH and non significantly increased in levels of LH. Prolactin concentrations that obtained revealed to significantly (p < 0.05) increased in patients with hypothyroidism . This study reported there were (70%) of hypothyroidism patients with menstrual disturbance. We concluded , that hypothyroidism and Hyperprolactinemia commonly related and synergized to menstrual irregularities and ovulatory failure. 

scholarly journals Safety of Ovaleap® (Follitropin Alfa) in Infertile Women Undergoing Superovulation for Assisted Reproductive Technologies: A Multinational Comparative, Prospective Cohort Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Sigal Kaplan ◽  
Rachel Levy-Toledano ◽  
Miranda Davies ◽  
Debabrata Roy ◽  
Colin M. Howles ◽  
...  
Keyword(s):  
Cohort Study ◽  
Live Birth ◽  
Assisted Reproductive Technologies ◽  
Follicle Stimulating Hormone ◽  
Reproductive Technologies ◽  
Birth Rates ◽  
Infertile Women ◽  
Live Birth Rates ◽  
Follitropin Alfa ◽  
Incidence Proportion

BackgroundOvaleap® (follitropin alfa), a recombinant human follicle stimulating hormone, is a biosimilar medicinal product to Gonal-f® and is used for ovarian stimulation. The main objective of this study was to assess the safety and effectiveness of Ovaleap® compared to Gonal-f® in one treatment cycle in routine clinical practice.MethodsSafety of Ovaleap® Follitropin alfa in Infertile women undergoing superovulation for Assisted reproductive technologies (SOFIA) was a prospective cohort study conducted in six European countries. Eligible patients were infertile women undergoing superovulation for assisted reproductive technology, who were administered Ovaleap® or Gonal-f® for ovarian stimulation and were naïve to follicle stimulating hormone treatment. The recruitment ratio was 1:1. The primary endpoint was incidence proportion of ovarian hyperstimulation syndrome (OHSS) and the secondary endpoint was OHSS severity (Grades I, II, III). The effect of risk factors or potential confounders on the odds ratio for OHSS incidence as well as treatment effect on OHSS incidence was explored using univariate logistic regression. Pregnancy and live birth rates were also assessed.ResultsA total of 408 women who were administered Ovaleap® and 409 women who were administered Gonal-f® were eligible for analysis. The incidence proportion of OHSS was 5.1% (95% CI: 3.4, 7.7) in the Ovaleap® cohort and 3.2% (95% CI: 1.9, 5.4) in the Gonal-f® cohort. This difference in OHSS incidence proportion between the two cohorts was not statistically significant neither before (p = 0.159) nor after univariate adjustment for each potential confounder (p &gt; 0.05). The incidence proportion of OHSS severity grades was similar in the two treatment groups (3.4% versus 2.0% for Grade I, 1.2% versus 1.0% for Grade II, and 0.5% versus 0.2% for Grade III, in the Ovaleap® and Gonal-f® cohorts, respectively), without a significant statistical difference (p = 0.865, for each grade). Among patients who had embryo transfer, clinical pregnancy rates were 33% and 31% and live birth rates were 27% and 26%, in the two cohorts, respectively.ConclusionsFindings from the SOFIA study indicate that the incidence proportions of OHSS and OHSS severity, as well as pregnancy and live birth rates, are similar between Ovaleap® and Gonal-f® treatments and corroborate the safety and effectiveness of Ovaleap® as a biosimilar to Gonal-f®.

scholarly journals Endometrial receptivity: the molecularmechanisms regulation of implantation

2013 ◽  
Vol 62 (2) ◽  
pp. 63-74 ◽  
Author(s):  
Yuliya Sergeyevna Krylova ◽  
Igor Moiseyevich Kvetnoy ◽  
Eduard Karpovich Aylamazyan
Keyword(s):  
Parameter Estimation ◽  
Molecular Mechanisms ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Signaling Molecules ◽  
Endometrial Receptivity

Presents current views on endometrial receptivity and the molecular mechanisms regulation of implantation. Examines the signaling molecules as potential markers of parameter estimation window of implantation in assisted reproductive technologies.

Changes in the Expression of Endometrial Receptivity Genes after Hysteroscopic Metroplasty in Infertile Women with Uterine Malformation

2021 ◽  
Vol 28 (11) ◽  
pp. S14-S15
Author(s):  
A. Di Spiezio Sardo ◽  
M.C. De Angelis ◽  
B. Zizolfi ◽  
V. Foreste ◽  
A. Gallo ◽  
...  
Keyword(s):  
Endometrial Receptivity ◽  
Infertile Women ◽  
Uterine Malformation

Progression in Human Melanoma Is Accompanied by the Altered Expression of Cell Adhesion Molecules

1993 ◽  
pp. 97-105
Author(s):  
J. P. Johnson ◽  
B. G. Stade ◽  
U. Rothbächer ◽  
S. Stratil ◽  
G. Riethmüller
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Human Melanoma ◽  
Altered Expression
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