Polymorphisms in Genes Coding for the NK-Cell Receptor NKG2D and its Ligand MICA in Recurrent Miscarriage

2014 ◽  
Vol 72 (6) ◽  
pp. 577-585 ◽  
Author(s):  
Sondes Hizem ◽  
Nabil Mtiraoui ◽  
Safia Massaoudi ◽  
Catherine Fortier ◽  
Wahid Boukouaci ◽  
...  
Keyword(s):  
Nk Cell ◽  
Recurrent Miscarriage ◽  
Cell Receptor ◽  
Nk Cell Receptor

scholarly journals Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer

2008 ◽  
Vol 123 (10) ◽  
pp. 2343-2353 ◽  
Author(s):  
Sonja Textor ◽  
Matthias Dürst ◽  
Lars Jansen ◽  
Rosita Accardi ◽  
Massimo Tommasino ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Nk Cell ◽  
Cell Receptor ◽  
Differentially Expressed ◽  
Receptor Ligands ◽  
Nk Cell Receptor

scholarly journals Functionally and Structurally Distinct NK Cell Receptor Repertoires in the Peripheral Blood of Two Human Donors

Immunity ◽  
1997 ◽  
Vol 7 (6) ◽  
pp. 739-751 ◽  
Author(s):  
Nicholas M Valiante ◽  
Markus Uhrberg ◽  
Heather G Shilling ◽  
Kristin Lienert-Weidenbach ◽  
Kelly L Arnett ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Nk Cell ◽  
Cell Receptor ◽  
Nk Cell Receptor

KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity

Blood ◽  
2004 ◽  
Vol 104 (9) ◽  
pp. 2858-2866 ◽  
Author(s):  
Yanmei Han ◽  
Minghui Zhang ◽  
Nan Li ◽  
Taoyong Chen ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Killer Cell ◽  
Cell Receptor ◽  
Sh2 Domain ◽  
Target Cells ◽  
Lymphoid Tissues ◽  
Nk Cell Receptor ◽  
Human And Mouse

Abstract Natural killer (NK) cell inhibitory receptors play important roles in the regulation of target susceptibility to natural killing. Here, we report the molecular cloning and functional characterization of a novel NK cell receptor, KLRL1, from human and mouse dendritic cells. KLRL1 is a type II transmembrane protein with an immunoreceptor tyrosine-based inhibitory motif and a C-type lectinlike domain. The KLRL1 gene is located in the central region of the NK gene complex in both humans and mice, on human chromosome 12p13 and mouse chromosome 6F3, adjacent to the other KLR genes. KLRL1 is preferentially expressed in lymphoid tissues and immune cells, including NK cells, T cells, dendritic cells, and monocytes or macrophages. Western blot and fluorescence confocal microscopy analyses indicated that KLRL1 is a membrane-associated glycoprotein, which forms a heterodimer with an as yet unidentified partner. Human and mouse KLRL1 are both predicted to contain putative immunoreceptor tyrosine-based inhibitory motifs (ITIMs), and immunoprecipitation experiments demonstrated that KLRL1 associates with the tyrosine phosphatases SHP-1 (SH2-domain-containing protein tyrosine phosphatase 1) and SHP-2. Consistent with its potential inhibitory function, pretreatment of target cells with human KLRL1-Fc fusion protein enhances NK-mediated cytotoxicity. Taken together, our results demonstrate that KLRL1 belongs to the KLR family and is a novel inhibitory NK cell receptor.

scholarly journals Back signaling of HLA class I molecules and T/ NK cell receptor ligands in epithelial cells reflects the rejection‐specific microenvironment in renal allograft biopsies

2019 ◽  
Vol 19 (10) ◽  
pp. 2692-2704 ◽  
Author(s):  
Johanna Egelkamp ◽  
Evgeny Chichelnitskiy ◽  
Jenny F. Kühne ◽  
Franziska Wandrer ◽  
Kerstin Daemen ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Renal Allograft ◽  
Nk Cell ◽  
Hla Class I ◽  
Cell Receptor ◽  
Class I ◽  
Receptor Ligands ◽  
Hla Class I Molecules ◽  
Nk Cell Receptor

scholarly journals Deletion of the activating NK cell receptor NKG2D accelerates rejection of cardiac allografts

2017 ◽  
Vol 17 (12) ◽  
pp. 3199-3209 ◽  
Author(s):  
Cornelia Fabritius ◽  
Paul Viktor Ritschl ◽  
Thomas Resch ◽  
Mario Roth ◽  
Susanne Ebner ◽  
...  
Keyword(s):  
Nk Cell ◽  
Cell Receptor ◽  
Cardiac Allografts ◽  
Nk Cell Receptor

Mono-allelic Ly49 NK cell receptor expression

1999 ◽  
Vol 11 (5) ◽  
pp. 349-355 ◽  
Author(s):  
Werner Held ◽  
Béatrice Kunz ◽  
Vasilios Ioannidis ◽  
Bente Lowin-Kropf
Keyword(s):  
Nk Cell ◽  
Cell Receptor ◽  
Receptor Expression ◽  
Nk Cell Receptor

scholarly journals The Structure of the Poxvirus A33 Protein Reveals a Dimer of Unique C-Type Lectin-Like Domains

2009 ◽  
Vol 84 (5) ◽  
pp. 2502-2510 ◽  
Author(s):  
Hua-Poo Su ◽  
Kavita Singh ◽  
Apostolos G. Gittis ◽  
David N. Garboczi
Keyword(s):  
Vaccinia Virus ◽  
Nk Cell ◽  
Structural Data ◽  
Cell Receptor ◽  
Viral Envelope ◽  
Crystal Lattices ◽  
Current Vaccine ◽  
Link Module ◽  
Nk Cell Receptor ◽  
Infectious Form

ABSTRACT The current vaccine against smallpox is an infectious form of vaccinia virus that has significant side effects. Alternative vaccine approaches using recombinant viral proteins are being developed. A target of subunit vaccine strategies is the poxvirus protein A33, a conserved protein in the Chordopoxvirinae subfamily of Poxviridae that is expressed on the outer viral envelope. Here we have determined the structure of the A33 ectodomain of vaccinia virus. The structure revealed C-type lectin-like domains (CTLDs) that occur as dimers in A33 crystals with five different crystal lattices. Comparison of the A33 dimer models shows that the A33 monomers have a degree of flexibility in position within the dimer. Structural comparisons show that the A33 monomer is a close match to the Link module class of CTLDs but that the A33 dimer is most similar to the natural killer (NK)-cell receptor class of CTLDs. Structural data on Link modules and NK-cell receptor-ligand complexes suggest a surface of A33 that could interact with viral or host ligands. The dimer interface is well conserved in all known A33 sequences, indicating an important role for the A33 dimer. The structure indicates how previously described A33 mutations disrupt protein folding and locates the positions of N-linked glycosylations and the epitope of a protective antibody.

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