scholarly journals Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer

2008 ◽  
Vol 123 (10) ◽  
pp. 2343-2353 ◽  
Author(s):  
Sonja Textor ◽  
Matthias Dürst ◽  
Lars Jansen ◽  
Rosita Accardi ◽  
Massimo Tommasino ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Nk Cell ◽  
Cell Receptor ◽  
Differentially Expressed ◽  
Receptor Ligands ◽  
Nk Cell Receptor

scholarly journals Back signaling of HLA class I molecules and T/ NK cell receptor ligands in epithelial cells reflects the rejection‐specific microenvironment in renal allograft biopsies

2019 ◽  
Vol 19 (10) ◽  
pp. 2692-2704 ◽  
Author(s):  
Johanna Egelkamp ◽  
Evgeny Chichelnitskiy ◽  
Jenny F. Kühne ◽  
Franziska Wandrer ◽  
Kerstin Daemen ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Renal Allograft ◽  
Nk Cell ◽  
Hla Class I ◽  
Cell Receptor ◽  
Class I ◽  
Receptor Ligands ◽  
Hla Class I Molecules ◽  
Nk Cell Receptor

CORRELATION OF SPECIFIC NK CELL RECEPTOR LIGANDS WITH COPD SEVERITY

CHEST Journal ◽  
2018 ◽  
Vol 154 (4) ◽  
pp. 766A
Author(s):  
JEFF MILLER ◽  
MICHAEL BORCHERS ◽  
ANDREW OSTERBURG
Keyword(s):  
Nk Cell ◽  
Cell Receptor ◽  
Receptor Ligands ◽  
Nk Cell Receptor

scholarly journals Expression of NK cell receptor ligands in primary colorectal cancer tissue in relation to the phenotype of circulating NK- and NKT cells, and clinical outcome

2020 ◽  
Vol 128 ◽  
pp. 205-218
Author(s):  
Daniëlle Krijgsman ◽  
Jessica Roelands ◽  
Morten N. Andersen ◽  
Cornelia H.L.A. Wieringa ◽  
Rob A.E.M. Tollenaar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Outcome ◽  
Nk Cell ◽  
Cell Receptor ◽  
Nkt Cells ◽  
Cancer Tissue ◽  
Primary Colorectal Cancer ◽  
Receptor Ligands ◽  
Colorectal Cancer Tissue ◽  
Nk Cell Receptor

scholarly journals Functionally and Structurally Distinct NK Cell Receptor Repertoires in the Peripheral Blood of Two Human Donors

Immunity ◽  
1997 ◽  
Vol 7 (6) ◽  
pp. 739-751 ◽  
Author(s):  
Nicholas M Valiante ◽  
Markus Uhrberg ◽  
Heather G Shilling ◽  
Kristin Lienert-Weidenbach ◽  
Kelly L Arnett ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Nk Cell ◽  
Cell Receptor ◽  
Nk Cell Receptor

KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity

Blood ◽  
2004 ◽  
Vol 104 (9) ◽  
pp. 2858-2866 ◽  
Author(s):  
Yanmei Han ◽  
Minghui Zhang ◽  
Nan Li ◽  
Taoyong Chen ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Killer Cell ◽  
Cell Receptor ◽  
Sh2 Domain ◽  
Target Cells ◽  
Lymphoid Tissues ◽  
Nk Cell Receptor ◽  
Human And Mouse

Abstract Natural killer (NK) cell inhibitory receptors play important roles in the regulation of target susceptibility to natural killing. Here, we report the molecular cloning and functional characterization of a novel NK cell receptor, KLRL1, from human and mouse dendritic cells. KLRL1 is a type II transmembrane protein with an immunoreceptor tyrosine-based inhibitory motif and a C-type lectinlike domain. The KLRL1 gene is located in the central region of the NK gene complex in both humans and mice, on human chromosome 12p13 and mouse chromosome 6F3, adjacent to the other KLR genes. KLRL1 is preferentially expressed in lymphoid tissues and immune cells, including NK cells, T cells, dendritic cells, and monocytes or macrophages. Western blot and fluorescence confocal microscopy analyses indicated that KLRL1 is a membrane-associated glycoprotein, which forms a heterodimer with an as yet unidentified partner. Human and mouse KLRL1 are both predicted to contain putative immunoreceptor tyrosine-based inhibitory motifs (ITIMs), and immunoprecipitation experiments demonstrated that KLRL1 associates with the tyrosine phosphatases SHP-1 (SH2-domain-containing protein tyrosine phosphatase 1) and SHP-2. Consistent with its potential inhibitory function, pretreatment of target cells with human KLRL1-Fc fusion protein enhances NK-mediated cytotoxicity. Taken together, our results demonstrate that KLRL1 belongs to the KLR family and is a novel inhibitory NK cell receptor.

scholarly journals Deletion of the activating NK cell receptor NKG2D accelerates rejection of cardiac allografts

2017 ◽  
Vol 17 (12) ◽  
pp. 3199-3209 ◽  
Author(s):  
Cornelia Fabritius ◽  
Paul Viktor Ritschl ◽  
Thomas Resch ◽  
Mario Roth ◽  
Susanne Ebner ◽  
...  
Keyword(s):  
Nk Cell ◽  
Cell Receptor ◽  
Cardiac Allografts ◽  
Nk Cell Receptor
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