scholarly journals Detection of Anti-HLA Antibodies in Maternal Blood in the Second Trimester to Identify Patients at Risk of Antibody-Mediated Maternal Anti-Fetal Rejection and Spontaneous Preterm Delivery

2013 ◽  
Vol 70 (2) ◽  
pp. 162-175 ◽  
Author(s):  
JoonHo Lee ◽  
Roberto Romero ◽  
Yi Xu ◽  
Jezid Miranda ◽  
Wonsuk Yoo ◽  
...  
Keyword(s):  
At Risk ◽  
Preterm Delivery ◽  
Maternal Blood ◽  
Second Trimester ◽  
Hla Antibodies ◽  
Spontaneous Preterm Delivery ◽  
Patients At Risk

scholarly journals Periodontal Disease, Inflammatory Cytokines, and PGE2 in Pregnant Patients at Risk of Preterm Delivery: A Pilot Study

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Catalina Latorre Uriza ◽  
Juliana Velosa-Porras ◽  
Nelly S. Roa ◽  
Stephani Margarita Quiñones Lara ◽  
Jaime Silva ◽  
...  
Keyword(s):  
At Risk ◽  
Pilot Study ◽  
High Risk ◽  
Periodontal Disease ◽  
Preterm Delivery ◽  
Inflammatory Cytokines ◽  
Inflammatory Responses ◽  
Low Risk ◽  
Prostaglandin E ◽  
Patients At Risk

Periodontal disease is an infection that, in pregnant women, can act as a risk factor for preterm delivery by increasing local and systemic inflammatory responses. Objective. To analyze the presence of periodontal disease, proinflammatory cytokines, and prostaglandin E2 (PGE2) in pregnant patients at high risk for preterm delivery. Materials and Methods. Pilot study for a case-control study. We included 46 pregnant patients (23 patients at risk of preterm delivery as cases and 23 patients without risk of preterm delivery as controls). We excluded patients who received periodontal treatment, antibiotics, or antimicrobials over the last 3 months as well as those with infections or diseases such as diabetes or hypercholesterolemia. The patients underwent a periodontal assessment, and their levels of cytokines (interleukin- [IL-] 2, IL-6, IL-10, and tumor necrosis factor- [TNF-] α) and prostaglandin E2 (PGE2) were quantified. Results. Patients with periodontal disease showed higher levels of cytokines (IL-2, IL-6, IL-10, and TNF-α) and PGE2. Patients at high risk for preterm birth showed higher IL levels compared with patients at low risk for preterm delivery. PGE2 increased with the severity of periodontal disease. PGE2 was higher in patients at low risk for preterm delivery, although this difference was not significant. Conclusion. Periodontal disease can increase the systemic inflammatory response as well as the levels of PGE2 and inflammatory cytokines in pregnant patients.

QUANTIFICATION OF PREFORMED HLA ANTIBODIES BY FLOW CYTOMETRY IDENTIFIES PATIENTS AT RISK FOR STEROID RESISTANT AND STEROID SENSITIVE LIVER TRANSPLANT REJECTION.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S183-S184
Author(s):  
Juan C. Scornik ◽  
Willem J. Van der Werf ◽  
Alan W. Hemming ◽  
Alan I. Reed ◽  
Consuelo Soldevilla Pico ◽  
...  
Keyword(s):  
At Risk ◽  
Flow Cytometry ◽  
Liver Transplant ◽  
Transplant Rejection ◽  
Hla Antibodies ◽  
Steroid Resistant ◽  
Patients At Risk ◽  
Steroid Sensitive ◽  
Liver Transplant Rejection

scholarly journals OC17.01: Risk assessment for early spontaneous preterm delivery combining markers from the first and second trimester of pregnancy

2010 ◽  
Vol 36 (S1) ◽  
pp. 32-32
Author(s):  
M. Parra-Cordero ◽  
D. Pedraza ◽  
G. Rencoret ◽  
H. Muñoz ◽  
R. Terra ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Preterm Delivery ◽  
Second Trimester ◽  
Spontaneous Preterm Delivery

Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-α and spontaneous preterm delivery in singleton pregnancies

2019 ◽  
Vol 47 (3) ◽  
pp. 304-310 ◽  
Author(s):  
Rauf Melekoglu ◽  
Ercan Yilmaz ◽  
Osman Ciftci ◽  
Yusuf Taner Kafadar ◽  
Ebru Celik
Keyword(s):  
Preterm Birth ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Preterm Delivery ◽  
Control Group ◽  
Second Trimester ◽  
Spontaneous Preterm Delivery ◽  
Tnf Α ◽  
Factor Α ◽  
Fluid Levels

Abstract Background We investigated the roles of inflammatory cytokines and the A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family in the etiopathogenesis of spontaneous preterm delivery by comparing the ADAMTS4, ADAMTS5, interleukin (IL)-6, and tumor necrosis factor-α (TNF-α) levels in second-trimester amniotic fluid between pregnant women with preterm birth and term controls. Methods All pregnant women who underwent second-trimester amniocentesis for genetic analysis between January 1, 2016, and January 1, 2018, were enrolled in this study. From this cohort, 22 patients who subsequently experienced spontaneous preterm delivery before 34 weeks of pregnancy formed the study group, and 22 age- and body mass index (BMI)-matched patients without preterm birth constituted the control group. Results No significant differences were observed between the preterm birth and control groups in terms of age, BMI, obstetric history of preterm delivery, gestational age at amniocentesis, or indication for amniocentesis. The mean amniotic fluid levels of ADAMTS4 and ADAMTS5 were significantly increased in the preterm birth group compared to the control group (248.3±22.6 and 182.4±19.8 pg/mL, P=0.012; and 198.6±21.6 and 159.1±21.7 pg/mL, P=0.035, respectively). Significantly increased IL-6 and TNF-α levels were also detected in the amniotic fluid of women who experienced spontaneous preterm delivery, relative to controls (142.1±16.2 and 95.8±16.4 pg/mL, P<0.001; and 139.4±12.5 and 89.6±11.2 pg/mL, P<0.001, respectively). Conclusion The results of this study imply that increased mid-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-α play an important role in the pathophysiology of spontaneous preterm delivery.

scholarly journals Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery

2010 ◽  
Vol 23 (12) ◽  
pp. 1344-1359 ◽  
Author(s):  
Roberto Romero ◽  
Shali Mazaki-Tovi ◽  
Edi Vaisbuch ◽  
Juan Pedro Kusanovic ◽  
Tinnakorn Chaiworapongsa ◽  
...  
Keyword(s):  
At Risk ◽  
Preterm Delivery ◽  
Premature Labor ◽  
Novel Approach ◽  
Patients At Risk

Early second trimester maternal plasma levels of thrombin-inhibitor complexes and subsequent spontaneous preterm delivery

2012 ◽  
Vol 32 (12) ◽  
pp. 1170-1173
Author(s):  
Da Eun Lee ◽  
So Yeon Park ◽  
June Seek Choi ◽  
Shin Young Kim ◽  
Ji Hyae Lim ◽  
...  
Keyword(s):  
Preterm Delivery ◽  
Plasma Levels ◽  
Maternal Plasma ◽  
Thrombin Inhibitor ◽  
Second Trimester ◽  
Spontaneous Preterm Delivery

Second-trimester uterine artery Doppler and spontaneous preterm delivery

2004 ◽  
Vol 24 (4) ◽  
pp. 435-439 ◽  
Author(s):  
F. Cobian-Sanchez ◽  
F. Prefumo ◽  
A. Bhide ◽  
B. Thilaganathan
Keyword(s):  
Preterm Delivery ◽  
Uterine Artery ◽  
Second Trimester ◽  
Uterine Artery Doppler ◽  
Spontaneous Preterm Delivery
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