CD40, CD80, and CD86 Costimulatory Molecules are Differentially Expressed on Murine Splenic Antigen-presenting Cells During the Pre-implantation Period of Pregnancy, and they Modulate Regulatory T-cell Abundance, Peripheral Cytokine Response, and Pregnanc

2013 ◽  
Vol 70 (2) ◽  
pp. 116-126 ◽  
Author(s):  
Anna Slawek ◽  
Tomasz Maj ◽  
Anna Chelmonska-Soyta
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Antigen Presenting Cells ◽  
Costimulatory Molecules ◽  
Cytokine Response ◽  
Differentially Expressed ◽  
Cell Abundance ◽  
Antigen Presenting ◽  
Implantation Period

scholarly journals Altered Decidual DC-SIGN+ Antigen-Presenting Cells and Impaired Regulatory T-Cell Induction in Preeclampsia

2012 ◽  
Vol 181 (6) ◽  
pp. 2149-2160 ◽  
Author(s):  
Peter Hsu ◽  
Brigitte Santner-Nanan ◽  
Jane E. Dahlstrom ◽  
Mitali Fadia ◽  
Arin Chandra ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Antigen Presenting Cells ◽  
Cell Induction ◽  
Antigen Presenting

Antigen-presenting cells exposed to Lactobacillus acidophilus NCFM, Bifidobacterium bifidum BI-98, and BI-504 reduce regulatory T cell activity

2010 ◽  
Vol 16 (3) ◽  
pp. 390-400 ◽  
Author(s):  
Esben Gjerlff Wedebye Schmidt ◽  
Mogens Helweg Claesson ◽  
Simon Skjde Jensen ◽  
Peter Ravn ◽  
Nanna Ny Kristensen
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Lactobacillus Acidophilus ◽  
Cell Activity ◽  
Antigen Presenting Cells ◽  
Bifidobacterium Bifidum ◽  
Lactobacillus Acidophilus Ncfm ◽  
Antigen Presenting

scholarly journals Chaperone-rich tumor cell lysate-mediated activation of antigen-presenting cells resists regulatory T cell suppression

2008 ◽  
Vol 83 (4) ◽  
pp. 1049-1059 ◽  
Author(s):  
N. Larmonier ◽  
J. Cantrell ◽  
C. LaCasse ◽  
G. Li ◽  
N. Janikashvili ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Cell ◽  
Regulatory T Cell ◽  
Antigen Presenting Cells ◽  
Cell Lysate ◽  
T Cell Suppression ◽  
Tumor Cell Lysate ◽  
Cell Suppression ◽  
Antigen Presenting

Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD

Blood ◽  
2007 ◽  
Vol 109 (11) ◽  
pp. 5049-5057 ◽  
Author(s):  
Kelli P. A. MacDonald ◽  
Rachel D. Kuns ◽  
Vanessa Rowe ◽  
Edward S. Morris ◽  
Tatjana Banovic ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Regulatory T Cell ◽  
Molecular Mechanisms ◽  
Cell Function ◽  
Nuclear Translocation ◽  
Tissue Injury ◽  
Antigen Presenting Cells ◽  
T Cell Function ◽  
Antigen Presenting

Abstract Antigen-presenting cells (APCs) are critical for the initiation of graft-versus-host disease (GVHD), although the responsible APC subset and molecular mechanisms remain unclear. Because dendritic cells (DCs) are the most potent APCs and the NF-kB/Rel family member RelB is associated with DC maturation and potent APC function, we examined their role in GVHD. Within 4 hours of total body irradiation, RelB nuclear translocation was increased and restricted to CD11chi DCs within the host APC compartment. Furthermore, the transient depletion of CD11chi donor DCs that reconstitute in the second week after transplantation resulted in a transient decrease in GVHD severity. By using RelB−/− bone marrow chimeras as transplant recipients or RelB−/− donor bone marrow, we demonstrate that the induction and maintenance of GVHD is critically dependent on this transcription factor within both host and donor APCs. Critically, RelB within APCs was required for the expansion of donor helper T cell type 1 (Th1) effectors and subsequent alloreactivity, but not the peripheral expansion or function of donor FoxP3+ regulatory T cells. These data suggest that the targeted inhibition of nuclear RelB translocation within APCs represents an attractive therapeutic strategy to dissociate effector and regulatory T-cell function in settings of Th1-mediated tissue injury.

Sa.116. Loss of Regulatory T Cell Function Mediated by Antigen Presenting Cells from Surgically Resected Colons from IBD Patients

2008 ◽  
Vol 127 ◽  
pp. S118
Author(s):  
James Lord ◽  
Richard Thirlby ◽  
Karine Valliant-Saunders ◽  
Amanda Moklebust ◽  
Robert Hackman ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Antigen Presenting Cells ◽  
T Cell Function ◽  
Antigen Presenting

scholarly journals CD80 and CD86 Costimulatory Molecules Differentially Regulate OT-II CD4+T Lymphocyte Proliferation and Cytokine Response in Cocultures with Antigen-Presenting Cells Derived from Pregnant and Pseudopregnant Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Tomasz Maj ◽  
Anna Slawek ◽  
Anna Chelmonska-Soyta
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
Costimulatory Molecule ◽  
Antigen Presenting Cells ◽  
Costimulatory Molecules ◽  
Cytokine Response ◽  
Cytokine Balance ◽  
T Lymphocyte Proliferation ◽  
Antigen Presenting

Immune phenomena during the preimplantation period of pregnancy are poorly understood. The aim of our study was to assess the capacity for antigen presentation of splenic antigen-presenting cells (APCs) derived from pregnant and pseudopregnant mice inin vitroconditions. Therefore, sorted CD11c+dendritic cells and macrophages F4/80+and CD11b+presenting ovalbumin (OVA) were cocultured with CD4+T cells derived from OT-II mice’s (C57BL6/J-Tg(TcraTcrb)1100Mjb/J) spleen. After 132 hours of cell culture, proliferation of lymphocytes (ELISA-BrdU), activation of these cells (flow cytometry), cytokine profile (ELISA), and influence of costimulatory molecules blocking on these parameters were measured. We did not detect any differences in regulation of Th1/Th2 cytokine balance. CD86 seems to be the main costimulatory molecule involved in the proliferation response but CD80 is the main costimulatory molecule influencing cytokine secretion in pregnant mice. In conclusion, this study showed that CD80 and CD86 costimulatory molecules regulate OT-II CD4+T lymphocyte proliferation and cytokine response in cocultures with antigen-presenting cells derived from pregnant and pseudopregnant mice. The implications of these changes still remain unclear.

scholarly journals Myeloma Bone Marrow Plasma Cells: Evidence for Their Capacity as Antigen-Presenting Cells

Blood ◽  
1997 ◽  
Vol 90 (5) ◽  
pp. 1960-1967 ◽  
Author(s):  
Qing Yi ◽  
Sunil Dabadghao ◽  
Anders Österborg ◽  
Susanne Bergenbrant ◽  
Göran Holm
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
T Cell ◽  
Plasma Cells ◽  
Antigen Presenting Cells ◽  
Costimulatory Molecules ◽  
Hla Dr ◽  
Hla Dq ◽  
Ifn Γ ◽  
Antigen Presenting

Abstract Myeloma plasma cells constitute 10% to 90% of the total bone marrow cell count in patients with multiple myeloma (MM). These cells express a variety of cell surface markers, such as HLA-ABC and HLA-DR, and surface antigens that are necessary for professional antigen-presenting cells, including adhesion and costimulatory molecules. In this study, we examined the expression of major histocompatability complex (MHC) and costimulatory molecules on CD38(bright,++) plasma cells in bone marrow aspirates from eight MM patients. Small percentages of plasma cells expressed weak but detectable levels of HLA-DR, HLA-DQ, CD40, CD80, and CD86, which could be upregulated by interferon-γ (IFN-γ) and tumor necrosis factor-α. CD38++ plasma cell and CD38(dim,+) cells were sorted from freshly isolated bone marrow mononuclear cells and tested for their capacity to act as antigen-presenting cells. Indeed, both CD38++ plasma cells and CD38+ cells were able to stimulate allogeneic T cells and present the soluble antigens purified protein derivative and tetanus toxoid to autologous T cells. Recognition of the antigens led to T-cell proliferation and secretion of IFN-γ and was MHC class-I and -II restricted. Antigen processing and presentation by CD38++ and CD38+ cells were abolished by treatment of the cells with chloroquine. Hence, our study provides for the first time evidence that myeloma plasma cells may act as antigen-presenting cells. Further studies are warranted to examine in detail the molecules required for inducing T-cell stimulation.

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