scholarly journals Altered Decidual DC-SIGN+ Antigen-Presenting Cells and Impaired Regulatory T-Cell Induction in Preeclampsia

2012 ◽  
Vol 181 (6) ◽  
pp. 2149-2160 ◽  
Author(s):  
Peter Hsu ◽  
Brigitte Santner-Nanan ◽  
Jane E. Dahlstrom ◽  
Mitali Fadia ◽  
Arin Chandra ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Antigen Presenting Cells ◽  
Cell Induction ◽  
Antigen Presenting

scholarly journals Biomimetic tolerogenic artificial antigen presenting cells for regulatory T cell induction

2020 ◽  
Vol 112 ◽  
pp. 136-148 ◽  
Author(s):  
Kelly R. Rhodes ◽  
Randall A. Meyer ◽  
Justin Wang ◽  
Stephany Y. Tzeng ◽  
Jordan J. Green
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Antigen Presenting Cells ◽  
Artificial Antigen ◽  
Cell Induction ◽  
Antigen Presenting

Antigen-presenting cells exposed to Lactobacillus acidophilus NCFM, Bifidobacterium bifidum BI-98, and BI-504 reduce regulatory T cell activity

2010 ◽  
Vol 16 (3) ◽  
pp. 390-400 ◽  
Author(s):  
Esben Gjerlff Wedebye Schmidt ◽  
Mogens Helweg Claesson ◽  
Simon Skjde Jensen ◽  
Peter Ravn ◽  
Nanna Ny Kristensen
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Lactobacillus Acidophilus ◽  
Cell Activity ◽  
Antigen Presenting Cells ◽  
Bifidobacterium Bifidum ◽  
Lactobacillus Acidophilus Ncfm ◽  
Antigen Presenting

scholarly journals Chaperone-rich tumor cell lysate-mediated activation of antigen-presenting cells resists regulatory T cell suppression

2008 ◽  
Vol 83 (4) ◽  
pp. 1049-1059 ◽  
Author(s):  
N. Larmonier ◽  
J. Cantrell ◽  
C. LaCasse ◽  
G. Li ◽  
N. Janikashvili ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Cell ◽  
Regulatory T Cell ◽  
Antigen Presenting Cells ◽  
Cell Lysate ◽  
T Cell Suppression ◽  
Tumor Cell Lysate ◽  
Cell Suppression ◽  
Antigen Presenting

Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD

Blood ◽  
2007 ◽  
Vol 109 (11) ◽  
pp. 5049-5057 ◽  
Author(s):  
Kelli P. A. MacDonald ◽  
Rachel D. Kuns ◽  
Vanessa Rowe ◽  
Edward S. Morris ◽  
Tatjana Banovic ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Regulatory T Cell ◽  
Molecular Mechanisms ◽  
Cell Function ◽  
Nuclear Translocation ◽  
Tissue Injury ◽  
Antigen Presenting Cells ◽  
T Cell Function ◽  
Antigen Presenting

Abstract Antigen-presenting cells (APCs) are critical for the initiation of graft-versus-host disease (GVHD), although the responsible APC subset and molecular mechanisms remain unclear. Because dendritic cells (DCs) are the most potent APCs and the NF-kB/Rel family member RelB is associated with DC maturation and potent APC function, we examined their role in GVHD. Within 4 hours of total body irradiation, RelB nuclear translocation was increased and restricted to CD11chi DCs within the host APC compartment. Furthermore, the transient depletion of CD11chi donor DCs that reconstitute in the second week after transplantation resulted in a transient decrease in GVHD severity. By using RelB−/− bone marrow chimeras as transplant recipients or RelB−/− donor bone marrow, we demonstrate that the induction and maintenance of GVHD is critically dependent on this transcription factor within both host and donor APCs. Critically, RelB within APCs was required for the expansion of donor helper T cell type 1 (Th1) effectors and subsequent alloreactivity, but not the peripheral expansion or function of donor FoxP3+ regulatory T cells. These data suggest that the targeted inhibition of nuclear RelB translocation within APCs represents an attractive therapeutic strategy to dissociate effector and regulatory T-cell function in settings of Th1-mediated tissue injury.

Sa.116. Loss of Regulatory T Cell Function Mediated by Antigen Presenting Cells from Surgically Resected Colons from IBD Patients

2008 ◽  
Vol 127 ◽  
pp. S118
Author(s):  
James Lord ◽  
Richard Thirlby ◽  
Karine Valliant-Saunders ◽  
Amanda Moklebust ◽  
Robert Hackman ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Antigen Presenting Cells ◽  
T Cell Function ◽  
Antigen Presenting

703 Aberrant Antigen Presenting Cells Activate Effector T Cells and Inhibit Regulatory T Cell Function

2009 ◽  
Vol 136 (5) ◽  
pp. A-111
Author(s):  
Deanna D. Nguyen ◽  
Michelle Eston ◽  
Elisa K. Boden ◽  
Bayasi Guleng ◽  
Hans-Christian Reinecker ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Function ◽  
Antigen Presenting Cells ◽  
Effector T Cells ◽  
T Cell Function ◽  
Antigen Presenting
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