Sweet's syndrome following surgery: Cutaneous trauma as a possible aetiological co-factor in neutrophilic dermatoses

2014 ◽  
Vol 56 (3) ◽  
pp. e74-e76 ◽  
Author(s):  
Rashi Minocha ◽  
Deshan F Sebaratnam ◽  
James YJ Choi
Keyword(s):  
Sweet’S Syndrome ◽  
Sweet's Syndrome ◽  
Neutrophilic Dermatoses

scholarly journals A rare case of Acute Febrile Neutrophilc Dermatosis – Sweet’s syndrome

2021 ◽  
Vol 12 (e) ◽  
pp. 1-4
Author(s):  
Ashwini Kodigehalli Chikkanna Swamy ◽  
Sandhaya Prasad ◽  
Anjan Kumar Patra
Keyword(s):  
Upper Body ◽  
Sweet’S Syndrome ◽  
Left Forearm ◽  
Sweet Syndrome ◽  
Sweet's Syndrome ◽  
Inflammatory Dermatosis ◽  
Neutrophilic Dermatoses ◽  
Laboratory Investigations ◽  
High Index Of Suspicion ◽  
Erythematous Plaques

Sweet syndrome is an inflammatory dermatosis characterized by non-itchy, sometimes tender, erythematous plaques and papules most commonly distributed on the arms, upper body, head and neck. Histological findings include a dense dermal neutrophilic infiltrate with oedema. We report a case of 32year old female patient with solitary well defined erythematous edematous plaques with whitish scales at the centre of the lesion present over the extensor aspect of left forearm since 5days with sparing of palms , soles and mucosae. Laboratory investigations and histopathology were suggestive of Neutrophilic dermatoses (Sweet’s syndrome). This case was presented to highlight Atypical presentationof sweet syndrome – annular morphology and localization of lesions only over left forearm Therefore high index of suspicion is needed for its diagnosis in cases of solitary and isolated presentation along with necessary histopathological and laboratory investigations.

Case Report of Sweet’s Syndrome Associated With Autoimmune Hepatitis

2016 ◽  
Vol 21 (1) ◽  
pp. 72-74 ◽  
Author(s):  
Allison K. Cinats ◽  
Richard M. Haber
Keyword(s):  
Autoimmune Hepatitis ◽  
Neutrophilic Dermatosis ◽  
Sweet’S Syndrome ◽  
Drug Induced ◽  
Sweet's Syndrome ◽  
Clinical Presentations ◽  
Neutrophilic Dermatoses ◽  
History Of ◽  
Erythematous Plaques ◽  
Elevated Transaminases

Autoimmune hepatitis is a subtle diagnosis that has many diverse clinical presentations. It has been reported in the literature to occur concomitantly with pyoderma gangrenosum, a neutrophilic dermatosis. Sweet’s syndrome is another neutrophilic dermatosis and has been reported to be associated with autoimmune hepatitis in only 2 previous cases: 1 idiopathic and 1 drug induced. Here we report a third case in a 24-year-old woman diagnosed with Sweet’s syndrome in association with autoimmune hepatitis, documenting a possible trend between neutrophilic dermatoses and autoimmune hepatitis. The patient presented with a history of fever and tender, erythematous plaques on her legs. Skin biopsy of a plaque confirmed histiocytoid Sweet’s syndrome. Initial laboratory investigations revealed elevated transaminases, and liver biopsy confirmed autoimmune hepatitis. This case suggests autoimmune hepatitis should be considered as an association when investigating a patient with Sweet’s syndrome.

Sweet’s Syndrome: A Frequently Unrecognized Complication Following Acute Myeloid Leukemia (Aml) Induction Chemotherapy: A Case Report.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4547-4547
Author(s):  
Toru Okura ◽  
David M. Aboulafia ◽  
Vincent Picozzi
Keyword(s):  
Case Report ◽  
Induction Chemotherapy ◽  
Subcutaneous Tissue ◽  
Hematologic Malignancies ◽  
Myelogenous Leukemia ◽  
Leukemic Cells ◽  
Sweet’S Syndrome ◽  
Unknown Etiology ◽  
Sweet's Syndrome ◽  
Neutrophilic Dermatoses

Abstract Sweet’s syndrome, also known as acute febrile neutrophilic dermatoses, is a distinct clinicopathologic entity of unknown etiology characterized by acute onset of fever, leukocytosis, and cutaneous plaques. It has been associated with a variety of disorders including infections, neoplasms, and autoimmune diseases. Paraneoplastic Sweet’s syndrome is most often associated with hematologic malignancies, including myelogenous leukemia and myelodysplastic syndrome (MDS), are most often associated. Although patients with neutrophilia are most likely to be diagnosed with Sweet’s syndrome, so, too, may patients who are neutropenic post-cytotoxic chemotherapy. Herein, we describe the clinical course of a 60-year-old Caucasian man with a history of high-risk MDS who, after progressing to AML and while neutropenic post-induction chemotherapy, was diagnosed with Sweet’s syndrome. The patient developed a warm, tender, indurated, erythematous lesion over his left anterior chest on day +6 of induction chemotherapy consisting of idarubicin and cytarabine. Despite broad spectrum antibiotics, the lesion darkened, formed blisters, and progressed rapidly to involve much of his left chest. On day +11, his WBC had fallen to 0.7×109cells/l and the wound was surgically debrided due to concern that he had developed necrotizing fasciitis. Surgical samples showed significant dermal infiltration of neutrophils and severe necrosis of skin and subcutaneous tissue, but no pathologic organisms or leukemic cells. Empiric antibiotic coverage was broadened to include amphotericin B, voriconazole, and valganciclovir, but the patient failed to improve. On day +18, he began taking 60mg Prednisone daily and his lesions quickly improved. Although Sweet’s syndrome most often occurs in conjunction with neutrophilia, it may also occur in neutropenic patients who have received systemic chemotherapy. This association with neutropenia is more frequent than is generally appreciated; as many as 20–50% of patients with hematologic malignancies may be diagnosed with Sweet’s syndrome while recovering from therapy-associated neutropenia. Cancer-associated Sweet’s syndrome may be more severe than that seen in patients without malignancy. Lesions may progress from plaques and nodules to vesicular, bullous, and even ulcerative skin lesions, as was seen in our patient. Our case report serves as a reminder that Sweet’s syndrome may occur in the setting of neutropenia and, if diagnosis and treatment are delayed, can lead to a life-threatening complication. Early skin biopsy and histopathologic assessment followed by corticosteroids is essential for recognition and management of this entity.

scholarly journals Neutrophilic dermatoses: pyoderma gangrenosum and Sweet's syndrome.

1997 ◽  
Vol 73 (856) ◽  
pp. 65-68 ◽  
Author(s):  
J. T. Lear ◽  
M. T. Atherton ◽  
J. P. Byrne
Keyword(s):  
Pyoderma Gangrenosum ◽  
Sweet’S Syndrome ◽  
Sweet's Syndrome ◽  
Neutrophilic Dermatoses

Sweet's syndrome associated with Salmonella enteritidis infection

1999 ◽  
Vol 24 (3) ◽  
pp. 239-240 ◽  
Author(s):  
Flórez ◽  
Sánchez-Aguilar ◽  
Rosón ◽  
Prieto ◽  
Van den Eyden ◽  
...  
Keyword(s):  
Salmonella Enteritidis ◽  
Sweet’S Syndrome ◽  
Sweet's Syndrome
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