scholarly journals Cerebral radiation necrosis

2013 ◽  
Vol 10 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Angelika Na ◽  
Neda Haghigi ◽  
Katharine J Drummond
Keyword(s):  
Radiation Necrosis ◽  
Cerebral Radiation Necrosis

Cerebral Radiation Necrosis: Incidence, Pathogenesis, Diagnostic Challenges, and Future Opportunities

2019 ◽  
Vol 21 (8) ◽  
Author(s):  
Faisal S. Ali ◽  
Octavio Arevalo ◽  
Soheil Zorofchian ◽  
Anthony Patrizz ◽  
Roy Riascos ◽  
...  
Keyword(s):  
Radiation Necrosis ◽  
Cerebral Radiation Necrosis

scholarly journals NCMP-01. COMPARISON AND QUANTITATION OF HISTOPATHOLOGY ABNORMALITIES IN SURGICALLY RESECTED CEREBRAL RADIATION NECROSIS AS COMPARED WITH RECURRENT BRAIN TUMOR FOLLOWING RADIATION

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi194-vi194
Author(s):  
Lisa Rogers ◽  
Curt Tatsuoka ◽  
Mitchell Machtay ◽  
Chaitra Badve ◽  
Pallavi Tiwari ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Radiation Necrosis ◽  
Cerebral Radiation Necrosis ◽  
Recurrent Brain Tumor

scholarly journals Adrenal Insufficiency in Patients with Corticosteroid-Refractory Cerebral Radiation Necrosis Treated with Bevacizumab

2019 ◽  
Vol 8 (10) ◽  
pp. 1608 ◽  
Author(s):  
Voss ◽  
Batarfi ◽  
Steidl ◽  
Wagner ◽  
Forster ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Steroid Therapy ◽  
Radiation Necrosis ◽  
Standard Of Care ◽  
Serum Cortisol ◽  
Hormone Substitution ◽  
Cerebral Radiation Necrosis ◽  
Bevacizumab Treatment ◽  
Highly Effective ◽  
Endothelial Growth Factor

Cerebral radiation necrosis is a common complication of the radiotherapy of brain tumours that can cause significant mortality. Corticosteroids are the standard of care, but their efficacy is limited and the consequences of long-term steroid therapy are problematic, including the risk of adrenal insufficiency (AI). Off-label treatment with the vascular endothelial growth factor A antibody bevacizumab is highly effective in steroid-resistant radiation necrosis. Both the preservation of neural tissue integrity and the cessation of steroid therapy are key goals of bevacizumab treatment. However, the withdrawal of steroids may be impossible in patients who develop AI. In order to elucidate the frequency of AI in patients with cerebral radiation necrosis after treatment with corticosteroids and bevacizumab, we performed a retrospective study at our institution’s brain tumour centre. We obtained data on the tumour histology, age, duration and maximum dose of dexamethasone, radiologic response to bevacizumab, serum cortisol, and the need for hydrocortisone substitution for AI. We identified 17 patients with cerebral radiation necrosis who had received treatment with bevacizumab and had at least one available cortisol analysis. Fifteen patients (88%) had a radiologic response to bevacizumab. Five of the 17 patients (29%) fulfilled criteria for AI and required hormone substitution. Age, duration of dexamethasone treatment, and time since radiation were not statistically associated with the development of AI. In summary, despite the highly effective treatment of cerebral radiation necrosis with bevacizumab, steroids could yet not be discontinued due to the development of AI in roughly one-third of patients. Vigilance to spot the clinical and laboratory signs of AI and appropriate testing and management are, therefore, mandated.

scholarly journals Laser Interstitial Thermal Therapy for Focal Cerebral Radiation Necrosis: A Case Report and Literature Review

2012 ◽  
Vol 90 (3) ◽  
pp. 192-200 ◽  
Author(s):  
Gazanfar Rahmathulla ◽  
Pablo F. Recinos ◽  
Jose E. Valerio ◽  
Sam Chao ◽  
Gene H. Barnett
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Radiation Necrosis ◽  
Thermal Therapy ◽  
Laser Interstitial Thermal Therapy ◽  
Cerebral Radiation Necrosis

Cerebral ?radiation necrosis?: Vascular and glial features

1976 ◽  
Vol 36 (4) ◽  
pp. 381-385 ◽  
Author(s):  
Muhammad M. Husain ◽  
Julio H. Garcia
Keyword(s):  
Radiation Necrosis ◽  
Cerebral Radiation Necrosis

Exacerbation of Cerebral Radiation Necrosis by Bevacizumab

2011 ◽  
Vol 29 (7) ◽  
pp. e159-e162 ◽  
Author(s):  
Deva Sanjeeva Jeyaretna ◽  
William T. Curry ◽  
Tracy T. Batchelor ◽  
Anat Stemmer-Rachamimov ◽  
Scott R. Plotkin
Keyword(s):  
Radiation Necrosis ◽  
Cerebral Radiation Necrosis
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