Quantitative trait loci mapping for conjugated linoleic acid, vaccenic acid and ∆9-desaturase in Italian Brown Swiss dairy cattle using selective DNA pooling

2014 ◽  
Vol 45 (4) ◽  
pp. 485-499 ◽  
Author(s):  
M. G. Strillacci ◽  
E. Frigo ◽  
F. Canavesi ◽  
Y. Ungar ◽  
F. Schiavini ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Quantitative Trait Loci ◽  
Dairy Cattle ◽  
Conjugated Linoleic Acid ◽  
Quantitative Trait ◽  
Vaccenic Acid ◽  
Quantitative Trait Loci Mapping ◽  
Dna Pooling ◽  
Brown Swiss ◽  
Selective Dna Pooling

scholarly journals Quantitative Trait Loci Mapping for Lameness Associated Phenotypes in Holstein–Friesian Dairy Cattle

2019 ◽  
Vol 10 ◽  
Author(s):  
Enrique Sánchez-Molano ◽  
Veysel Bay ◽  
Robert F. Smith ◽  
Georgios Oikonomou ◽  
Georgios Banos
Keyword(s):  
Quantitative Trait Loci ◽  
Dairy Cattle ◽  
Quantitative Trait ◽  
Quantitative Trait Loci Mapping ◽  
Holstein Friesian ◽  
Trait Loci

scholarly journals A Whole Genome Scan for Quantitative Trait Loci Affecting Milk Protein Percentage in Israeli-Holstein Cattle, by Means of Selective Milk DNA Pooling in a Daughter Design, Using an Adjusted False Discovery Rate Criterion

Genetics ◽  
2001 ◽  
Vol 157 (4) ◽  
pp. 1683-1698 ◽  
Author(s):  
Mathias O Mosig ◽  
Ehud Lipkin ◽  
Galina Khutoreskaya ◽  
Elena Tchourzyna ◽  
Morris Soller ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
False Discovery Rate ◽  
Quantitative Trait ◽  
Milk Protein ◽  
Dna Pooling ◽  
Protein Percentage ◽  
False Discovery ◽  
Data Points ◽  
Selective Dna Pooling ◽  
Daughter Design

Abstract Selective DNA pooling was employed in a daughter design to screen all bovine autosomes for quantitative trait loci (QTL) affecting estimated breeding value for milk protein percentage (EBVP%). Milk pools prepared from high and low daughters of each of seven sires were genotyped for 138 dinucleotide microsatellites. Shadow-corrected estimates of sire allele frequencies were compared between high and low pools. An adjusted false discovery rate (FDR) method was employed to calculate experimentwise significance levels and empirical power. Significant associations with milk protein percentage were found for 61 of the markers (adjusted FDR = 0.10; estimated power, 0.68). The significant markers appear to be linked to 19–28 QTL. Mean allele substitution effects of the putative QTL averaged 0.016 (0.009–0.028) in units of the within-sire family standard deviation of EBVP% and summed to 0.460 EBVP%. Overall QTL heterozygosity was 0.40. The identified QTL appear to account for all of the variation in EBVP% in the population. Through use of selective DNA pooling, 4400 pool data points provided the statistical power of 600,000 individual data points.

scholarly journals Quantitative trait loci mapping in dairy cattle: review and meta-analysis

2004 ◽  
Vol 36 (2) ◽  
pp. 163 ◽  
Author(s):  
Mehar S Khatkar ◽  
Peter C Thomson ◽  
Imke Tammen ◽  
Herman W Raadsma
Keyword(s):  
Quantitative Trait Loci ◽  
Dairy Cattle ◽  
Quantitative Trait ◽  
Meta Analysis ◽  
Quantitative Trait Loci Mapping ◽  
Trait Loci

scholarly journals cis-9, trans-11 Conjugated Linoleic Acid Is Synthesized Directly from Vaccenic Acid in Lactating Dairy Cattle

2006 ◽  
Vol 136 (3) ◽  
pp. 570-575 ◽  
Author(s):  
Erin E. Mosley ◽  
Bahman Shafii† ◽  
Peter J. Moate ◽  
Mark A. McGuire
Keyword(s):  
Linoleic Acid ◽  
Dairy Cattle ◽  
Conjugated Linoleic Acid ◽  
Vaccenic Acid ◽  
Lactating Dairy Cattle

scholarly journals Quantitative Trait Locus Mapping in Dairy Cattle by Means of Selective Milk DNA Pooling Using Dinucleotide Microsatellite Markers: Analysis of Milk Protein Percentage

Genetics ◽  
1998 ◽  
Vol 149 (3) ◽  
pp. 1557-1567 ◽  
Author(s):  
Ehud Lipkin ◽  
Mathias O Mosig ◽  
Ariel Darvasi ◽  
Ephraim Ezra ◽  
A Shalom ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Dairy Cattle ◽  
Quantitative Trait ◽  
Statistical Power ◽  
Milk Protein ◽  
Dna Pooling ◽  
Marker Allele ◽  
Protein Percentage ◽  
Trait Locus ◽  
Selective Dna Pooling

Abstract “Selective DNA pooling” accomplishes quantitative trait locus (QTL) mapping through densitometric estimates of marker allele frequencies in pooled DNA samples of phenotypically extreme individuals. With poly(TG) microsatellites, such estimates are confounded by “shadow” (“stutter”) bands. A correction procedure was developed on the basis of an observed linear regression between shadow band intensity and allele TG repeat number. Using this procedure, a selective DNA pooling study with respect to milk protein percentage was implemented in Israel-Holstein dairy cattle. Pools were prepared from milk samples of high and low daughters of each of seven sires and genotyped with respect to 11 markers. Highly significant associations with milk protein percentage were found for 5 of the markers; 4 of these markers confirmed previous reports. Selective DNA pooling accessed 80.6 and 48.3%, respectively, of the information that would have been available through individual selective genotyping or total population genotyping. In effect, the statistical power of 45,600 individual genotypings was obtained from 328 pool genotypings. This methodology can make genome-wide mapping of QTL accessible to moderately sized breeding organizations.

scholarly journals Diets Rich in Conjugated Linoleic Acid and Vaccenic Acid Have No Effect on Blood Pressure and Isobaric Arterial Elasticity in Healthy Young Men

2006 ◽  
Vol 136 (4) ◽  
pp. 992-997 ◽  
Author(s):  
Marianne Raff ◽  
Tine Tholstrup ◽  
Kristen Sejrsen ◽  
Ellen M. Straarup ◽  
Niels Wiinberg
Keyword(s):  
Blood Pressure ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Vaccenic Acid ◽  
Young Men ◽  
Arterial Elasticity
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