scholarly journals Circadian gene × environment perturbations influence alcohol drinking in Cryptochrome ‐deficient mice

2021 ◽  
Author(s):  
Anisja Hühne ◽  
Lisa Echtler ◽  
Charlotte Kling ◽  
Marius Stephan ◽  
Mathias V. Schmidt ◽  
...  
Keyword(s):  
Alcohol Drinking ◽  
Circadian Gene ◽  
Gene Environment ◽  
Deficient Mice

scholarly journals Correction: Differential Effects of Prenatal Stress in 5-Htt Deficient Mice: Towards Molecular Mechanisms of Gene × Environment Interactions

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
Author(s):  
Daniel Louis Albert van den Hove ◽  
Sissi Brigitte Jakob ◽  
Karla-Gerlinde Schraut ◽  
Gunter Kenis ◽  
Angelika Gertrud Schmitt ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Molecular Mechanisms ◽  
Differential Effects ◽  
Gene Environment ◽  
Deficient Mice

Alcohol drinking and related behaviors in hypothalamic-specific Pomc-deficient mice

2015 ◽  
Vol 146 ◽  
pp. e31-e32
Author(s):  
Yan Zhou ◽  
M. Rubinstein ◽  
Malcolm J. Low ◽  
Mary Jeanne Kreek
Keyword(s):  
Alcohol Drinking ◽  
Deficient Mice

scholarly journals Interaction between ELMO1 gene polymorphisms and environment factors on susceptibility to diabetic nephropathy in Chinese Han population

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Yi Hou ◽  
Yong Gao ◽  
Yan Zhang ◽  
Si-Tong Lin ◽  
Yue Yu ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Alcohol Drinking ◽  
Control Group ◽  
Environment Interaction ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Increased Risk ◽  
Significant Gene

Abstract Background The association of diabetic nephropathy (DN) risk with single nucleotide polymorphisms (SNPs) within Engulfment and Cell Motility 1 (ELMO1) gene and gene–environment synergistic effect have not been extensively examined in, therefore, the purpose of this study is to explore the association between multiple SNPs in ELMO1 gene, and the relationship between gene–environment synergy effect and the risk of DN. Methods Genotyping for 4 SNPs was performed with polymerase chain reaction (PCR) and following restriction fragment length polymorphism (RFLP) methods. Hardy–Weinberg balance of the control group was tested by SNPstats (online software: http://bioinfo.iconologia.net/snpstats). The best combination of four SNPs of ELMO1 gene and environmental factors was screened by GMDR model. Logistic regression was used to calculating the OR values between different genotypes of ELMO1 gene and DN. Results The rs741301-G allele and the rs10255208-GG genotype were associated with an increased risk of DN risk, adjusted ORs (95% CI) were 1.75 (1.19–2.28) and 1.41 (1.06–1.92), respectively, both p-values were < 0.001. We also found that the others SNPs-rs1345365 and rs7782979 were not significantly associated with susceptibility to DN. GMDR model found a significant gene–alcohol drinking interaction combination (p = 0.0107), but no significant gene–hypertension interaction combinations. Alcohol drinkers with rs741301-AG/GG genotype also have the highest DN risk, compared to never drinkers with rs741301-AA genotype, OR (95% CI) 3.52 (1.93–4.98). Conclusions The rs741301-G allele and the rs10255208-GG genotype, gene–environment interaction between rs741301 and alcohol drinking were all associated with increased DN risk.

scholarly journals No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yan-Shen Shan ◽  
Li-Tzong Chen ◽  
Chih-Hsing Wu ◽  
Yin-Fan Chang ◽  
Chih-Ting Lee ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Alcohol Consumption ◽  
Alcohol Use ◽  
Cancer Risk ◽  
Alcohol Drinking ◽  
Environment Interaction ◽  
Carcinogenic Effect ◽  
Pancreatic Cancer Risk ◽  
Gene Environment ◽  
Slow Activity

AbstractInconsistent results have been reported for the association between alcohol use and pancreatic cancer, particularly at low levels of alcohol consumption. Individuals genetically susceptible to the carcinogenic effect of alcohol might have higher pancreatic cancer risk after drinking alcohol. The current study investigated the association between alcohol use and pancreatic cancer with 419 pancreatic cancer cases and 963 controls recruited by a hospital-based case–control study in Taiwan. Gene-environment interaction between alcohol use and polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on pancreatic risk was evaluated. Our results showed no significant association between alcohol drinking and an increased pancreatic cancer risk, even at high levels of alcohol consumption. Even among those genetically susceptible to the carcinogenic effect of alcohol (carriers of ADH1B*2/*2(fast activity) combined with ALDH2*1/*2(slow activity) or ALDH2*2/*2(almost non-functional)), no significant association between alcohol use and pancreatic cancer was observed. Overall, our results suggested that alcohol drinking is not a significant contributor to the occurrence of pancreatic cancer in Taiwan.

Alcohol Drinking in MCH Receptor-1-Deficient Mice

2007 ◽  
Vol 31 (8) ◽  
pp. 1325-1337 ◽  
Author(s):  
Elizabeth A. Duncan ◽  
Joyce E. Sorrell ◽  
Antoine Adamantidis ◽  
Therese Rider ◽  
Ronald J. Jandacek ◽  
...  
Keyword(s):  
Alcohol Drinking ◽  
Deficient Mice
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