scholarly journals Accelerated aging and motor control deficits are related to regional deformation of central cerebellar white matter in alcohol use disorder

2019 ◽  
Vol 25 (3) ◽  
Author(s):  
Qingyu Zhao ◽  
Adolf Pfefferbaum ◽  
Simon Podhajsky ◽  
Kilian M. Pohl ◽  
Edith V. Sullivan
Keyword(s):  
Motor Control ◽  
White Matter ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Accelerated Aging ◽  
Cerebellar White Matter ◽  
Regional Deformation

scholarly journals Microstructural damage of white-matter tracts connecting large-scale networks is related to impaired executive profile in alcohol use disorder

2020 ◽  
Vol 25 ◽  
pp. 102141 ◽  
Author(s):  
Chiara Crespi ◽  
Caterina Galandra ◽  
Nicola Canessa ◽  
Marina Manera ◽  
Paolo Poggi ◽  
...  
Keyword(s):  
White Matter ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Large Scale ◽  
White Matter Tracts ◽  
Microstructural Damage ◽  
Large Scale Networks

scholarly journals Differences in White Matter Microstructure and Connectivity in Nontreatment-Seeking Individuals with Alcohol Use Disorder

2018 ◽  
Vol 42 (5) ◽  
pp. 889-896 ◽  
Author(s):  
Evgeny J. Chumin ◽  
Joaquín Goñi ◽  
Meredith E. Halcomb ◽  
Timothy C. Durazzo ◽  
Mario Dzemidzic ◽  
...  
Keyword(s):  
White Matter ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
White Matter Microstructure

scholarly journals Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence

2019 ◽  
Vol 76 (7) ◽  
pp. 749 ◽  
Author(s):  
Silvia De Santis ◽  
Patrick Bach ◽  
Laura Pérez-Cervera ◽  
Alejandro Cosa-Linan ◽  
Georg Weil ◽  
...  
Keyword(s):  
White Matter ◽  
Alcohol Consumption ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol

scholarly journals A coordinate-based meta-analysis of white matter alterations in patients with alcohol use disorder

2021 ◽  
Author(s):  
Carolin Spindler ◽  
Louisa Mallien ◽  
Sebastian Trautmann ◽  
Nina Alexander ◽  
Markus Muehlhan
Keyword(s):  
White Matter ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Diffusion Tensor ◽  
Meta Analysis ◽  
Internal Capsule ◽  
Likelihood Estimation ◽  
Posterior Limb ◽  
Reference Space ◽  
The Right

Introduction: Besides the commonly described grey matter (GM) deficits, there is growing evidence of significant white matter (WM) alterations in patients with alcohol use disorder (AUD). WM changes can be assessed using volumetric and diffusive magnetic resonance imaging methods, such as voxel-based morphometry (VBM) and diffusion tensor imaging (DTI). The aim of the present meta-analysis is to investigate the spatial convergence of the reported findings on WM alterations in AUD. Methods: Systematic literature search on PubMed and further databases revealed 18 studies eligible for inclusion, entailing a total of 462 AUD patients and 416 healthy controls (up to January 18, 2021). All studies that had used either VBM or DTI whole-brain analyzing methods and reported results as peak-coordinates in standard reference space were considered for inclusion. We excluded studies using approaches nonconcordant with recent guidelines for neuroimaging meta-analyses and studies investigating patient groups with Korsakoff syndrome or other comorbid substance use disorders (except tobacco). Results: Anatomical Likelihood Estimation (ALE) revealed four significant clusters of convergent macro- and microstructural WM alterations in AUD patients that were assigned to the genu and body of the corpus callosum, anterior and posterior cingulum, fornix, and the right posterior limb of the internal capsule. Discussion: The changes in WM could to some extent explain the deteriorations in motor, cognitive, affective, and perceptual functions seen in AUD. Future studies are needed to clarify how WM alterations vary over the course of the disorder and to what extent they are reversible with prolonged abstinence.

scholarly journals Measures of possible allostatic load in comorbid cocaine and alcohol use disorder: Brain white matter integrity, telomere length, and anti-saccade performance

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0199729 ◽  
Author(s):  
Jonika Tannous ◽  
Benson Mwangi ◽  
Khader M. Hasan ◽  
Ponnada A. Narayana ◽  
Joel L. Steinberg ◽  
...  
Keyword(s):  
White Matter ◽  
Alcohol Use ◽  
Telomere Length ◽  
Allostatic Load ◽  
Alcohol Use Disorder ◽  
White Matter Integrity ◽  
Brain White Matter

scholarly journals Hippocampal subfield CA2+3 exhibits accelerated aging in Alcohol Use Disorder: A preliminary study

2019 ◽  
Vol 22 ◽  
pp. 101764 ◽  
Author(s):  
Natalie M. Zahr ◽  
Kilian M. Pohl ◽  
Manojkumar Saranathan ◽  
Edith V. Sullivan ◽  
Adolf Pfefferbaum
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Accelerated Aging ◽  
Preliminary Study
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