Cannabis and bipolar disorder: does quitting cannabis use during manic/mixed episode improve clinical/functional outcomes?

2014 ◽  
Vol 131 (2) ◽  
pp. 100-110 ◽  
Author(s):  
I. Zorrilla ◽  
J. Aguado ◽  
J. M. Haro ◽  
S. Barbeito ◽  
S. López Zurbano ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Functional Outcomes ◽  
Cannabis Use ◽  
Mixed Episode

P.2.d.055 Cannabis and bipolar disorder: does quitting cannabis use during manic/mixed episode improve clinical/functional outcomes?

2014 ◽  
Vol 24 ◽  
pp. S446
Author(s):  
N.I. Nuñez Morales ◽  
S. López Zurbano ◽  
M.P. López-Peña ◽  
I. Zorrilla ◽  
A.M. González-Pinto
Keyword(s):  
Bipolar Disorder ◽  
Functional Outcomes ◽  
Cannabis Use ◽  
Mixed Episode

12-Month Outcome of Patients With Bipolar Disorder Following Hospitalization for a Manic or Mixed Episode

2003 ◽  
Vol 1 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Paul E. Keck ◽  
Susan L. McElroy ◽  
Stephen M. Strakowski ◽  
Scott A. West ◽  
Kenji W. Sax ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Mixed Episode

scholarly journals Functional and Mood Outcomes in Bipolar Disorder Patients With and Without Substance Use Disorders Undergoing Psychotherapy

2021 ◽  
Vol 12 ◽  
Author(s):  
William Moot ◽  
Marie Crowe ◽  
Maree Inder ◽  
Kate Eggleston ◽  
Christopher Frampton ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Substance Use ◽  
Social Adjustment ◽  
Functional Outcomes ◽  
Secondary Analysis ◽  
Adjunctive Treatment ◽  
Life Score ◽  
The Social ◽  
Negative Effect ◽  
Social Rhythm

Objectives: Research suggests that patients with co-morbid bipolar disorder (BD) and substance use disorder (SUD) have a poorer illness course and clinical outcome. The evidence is limited as SUD patients are often excluded from BD studies. In particular, evidence regarding long term outcomes from studies using psychotherapies as an adjunctive treatment is limited. We therefore examined data from two studies of Interpersonal Social Rhythm Therapy (IPSRT) for BD to determine whether lifetime or current SUD affected outcomes.Methods: Data were analyzed from two previous clinical trials of IPSRT for BD patients. Change in scores on the Social Adjustment Scale (SAS) from 0 to 78 weeks and cumulative mood scores from 0 to 78 weeks, measured using the Life Interval Follow-Up Evaluation (LIFE), were analyzed.Results: Of 122 patients (non-SUD n = 67, lifetime SUD but no current n = 43, current SUD n = 12), 79 received IPSRT and 43 received a comparison therapy—specialist supportive care—over 18 months. Lifetime SUD had a significant negative effect on change in SAS score but not LIFE score. There was no effect of current SUD on either change in score. Secondary analysis showed no correlation between symptom count and change in SAS total score or LIFE score.Conclusion: Current SUD has no impact on mood or functional outcomes, however, current SUD numbers were small, limiting conclusions. Lifetime SUD appears to be associated with impaired functional outcomes from psychotherapy. There is limited research on co-morbid BD and SUD patients undergoing psychotherapy.

scholarly journals Recent Perceived Stress, Amygdala Reactivity to Acute Psychosocial Stress, and Alcohol and Cannabis Use in Adolescents and Young Adults With Bipolar Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Vanessa Le ◽  
Dylan E. Kirsch ◽  
Valeria Tretyak ◽  
Wade Weber ◽  
Stephen M. Strakowski ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Substance Use ◽  
Young Adults ◽  
Perceived Stress ◽  
Psychosocial Stress ◽  
Acute Stress ◽  
Cannabis Use ◽  
Typically Developing ◽  
Amygdala Activation ◽  
Amygdala Reactivity

Background: Psychosocial stress negatively affects the clinical course of bipolar disorder. Studies primarily focused on adults with bipolar disorder suggest the impact of stress is progressive, i.e., stress response sensitizes with age. Neural mechanisms underlying stress sensitization are unknown. As stress-related mechanisms contribute to alcohol/substance use disorders, variation in stress response in youth with bipolar disorder may contribute to development of co-occurring alcohol/substance use disorders. This study investigated relations between psychosocial stress, amygdala reactivity, and alcohol and cannabis use in youth with bipolar disorder, compared to typically developing youth.Methods: Forty-two adolescents/young adults [19 with bipolar disorder, 23 typically developing, 71% female, agemean ± SD = 21 ± 2 years] completed the Perceived Stress Scale (PSS), Daily Drinking Questionnaire modified for heaviest drinking week, and a modified Montreal Imaging Stress functional MRI Task. Amygdala activation was measured for both the control and stress conditions. Main effects of group, condition, total PSS, and their interactions on amygdala activation were modeled. Relationships between amygdala response to acute stress with recent alcohol/cannabis use were investigated.Results: Greater perceived stress related to increased right amygdala activation in response to the stress, compared to control, condition in bipolar disorder, but not in typically developing youth (group × condition × PSS interaction, p = 0.02). Greater amygdala reactivity to acute stress correlated with greater quantity and frequency of alcohol use and frequency of cannabis use in bipolar disorder.Conclusion: Recent perceived stress is associated with changes in amygdala activation during acute stress with amygdala reactivity related to alcohol/cannabis use in youth with bipolar disorder.

scholarly journals Psychotic symptoms in bipolar disorder: Two years’ retrospective study

2017 ◽  
Vol 13 (1) ◽  
pp. 49-57
Author(s):  
Baikuntha Raj Adhikari ◽  
S Mishra ◽  
S Nepal ◽  
N Sapkota
Keyword(s):  
Bipolar Disorder ◽  
Retrospective Study ◽  
Bipolar Depression ◽  
Bipolar Disorders ◽  
Unipolar Depression ◽  
Common Type ◽  
Psychotic Symptoms ◽  
Mixed Episode ◽  
Auditory Verbal Hallucinations ◽  
Primary Substance

Background: Psychosis in bipolar disorder is common but still not well understood. There is paucity of literature from our country and none from this institute which serves the eastern part of Nepal.Objective: To describe the hallucinations and delusions in bipolar disorders in our place.Methods: Patients-record files of bipolar disorders with psychosis discharged in two years’ time from 2012 to 2014 were analysed. Patients with unipolar depression, recurrent depressive disorder, serious organic illness, and primary substance use disorders were excluded. Information was collected in a structured performa. Association of delusion and hallucination was observed.Results: During the study period, ninety-five patients with bipolardisorder had psychosis. Hallucination was present in 29 (30.5%) cases, and out of these 23 (79.3%) were cases of mania. In 26 (89.7%) patients, the hallucinations were mood congruent. The median duration of appearance of hallucination was 10 days and appeared early in mania. Among hallucinations, auditory verbal hallucinations were present in all 29 patients. Delusions were present in 77 (81.1%) of patients, and grandiose delusions were the most common. Grandiose delusions tended to occur even in the absence of hallucinations. Conclusion: Psychosis is common in bipolar disorder. Grandiose delusions are the most common delusion and are relatively independent of hallucination. The auditory verbal hallucinations are the most common type of hallucination. Hallucinations in mania tend to manifest earlier than in bipolar depression and mixed episode, and most of the hallucinations in bipolar disorder are mood congruent. Health Renaissance 2015;13 (1): 49-57

scholarly journals The influence of stage of illness on functional outcomes after psychological treatment in bipolar disorder: A systematic review

2020 ◽  
Vol 22 (7) ◽  
pp. 666-692
Author(s):  
Hailey Tremain ◽  
Kathryn Fletcher ◽  
Jan Scott ◽  
Carla McEnery ◽  
Michael Berk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Functional Outcomes ◽  
Psychological Treatment

Sex differences in bipolar disorder: Impact of lifetime cannabis use on clinical course, functioning, and quality of life in bipolar disorder

2020 ◽  
Vol 266 ◽  
pp. 258-262 ◽  
Author(s):  
Lorena de la Fuente-Tomás ◽  
Belén Arranz ◽  
Angela Velasco ◽  
Pilar Sierra ◽  
Mónica Sanchez-Autet ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bipolar Disorder ◽  
Sex Differences ◽  
Clinical Course ◽  
Cannabis Use
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