Protective Effects of Facilitated Removal of Blood Alcohol and Acetaldehyde Against Liver Injury in Animal Models Fed Alcohol and Anti‐HIV Drugs

Alcoholism Clinical and Experimental Research ◽

10.1111/acer.14034 ◽

2019 ◽

Cited By ~ 1

Author(s):

Hui Han ◽

Yuxin He ◽

Heather Johnson ◽

Pratibha Mishra ◽

Harrison Lee ◽

...

Keyword(s):

Animal Models ◽

Liver Injury ◽

Blood Alcohol ◽

Protective Effects ◽

Hiv Drugs ◽

Anti Hiv

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P237 Enzyme complexes of alcohol metabolism protect against liver injury in animal models fed acute alcohol and anti-HIV drugs

10.1136/sextrans-2019-sti.373 ◽

2019 ◽

Author(s):

Cheng Ji

Keyword(s):

Animal Models ◽

Liver Injury ◽

Alcohol Metabolism ◽

Hiv Drugs ◽

Enzyme Complexes ◽

Anti Hiv

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Animal models of anti-HIV drugs exposure during pregnancy

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/s0278-5846(01)00325-6 ◽

2002 ◽

Vol 26 (4) ◽

pp. 747-761 ◽

Cited By ~ 9

Author(s):

Aldina Venerosi ◽

Gemma Calamandrei ◽

Enrico Alleva

Keyword(s):

Animal Models ◽

Exposure During Pregnancy ◽

Hiv Drugs ◽

Anti Hiv

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Protective effects of mildronate in indinavir- and efavirenz-induced toxicity in mice

Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences ◽

10.2478/v10046-010-0025-6 ◽

2010 ◽

Vol 64 (3-4) ◽

pp. 119-124

Author(s):

Jolanta Pupure ◽

Sergejs Isajevs ◽

Ivars Kalviņš ◽

Vija Kluša

Keyword(s):

Reverse Transcriptase ◽

Brain Tissue ◽

Liver Mitochondria ◽

Transcriptase Inhibitor ◽

Heart Tissue ◽

Rat Liver Mitochondria ◽

Protective Effects ◽

Hiv Drugs ◽

Reverse Transcriptase Inhibitor ◽

Anti Hiv

Protective effects of mildronate in indinavir- and efavirenz-induced toxicity in mice Previously we showed that mildronate effectively protected mice heart tissue against the toxic influence of anti-HIV drugs azidothymidine, stavudine and lamivudine, which belong to nucleosideanalogue reverse transcriptase inhibitor (NRTI) class. Recently we also demonstrated that mildronate protected isolated rat liver mitochondria against mitochondrial damage caused by azidothymidine. The present study was devoted to examine the possible protective effectiveness of mildronate in cardio-, hepato- and neurotoxicity models caused by anti-HIV drugs of other classes: indinavir, a representative of protease inhibitor (PI) class, and efavirenz, a non-nucleoside-analogue reverse transcriptase inhibitor (NNRTI). Drugs were administered intraperitoneally for two weeks, at the dose of 50 mg/kg of anti-HIV drugs and 100 mg/kg for mildronate. Afterwards, mice heart, liver and brain tissue were examined morphologically and immunohistochemically. The results showed that indinavir in heart tissue caused inflammatory and degenerative changes, manifested as increased expression of nuclear factor kappaBp65 (NF-kBp65), as well as cardiomyocyte necrosis and cellular infiltration. Efavirenz did not cause pathological changes in mice heart tissue, whereas it induced marked expression of caspase-3 and glial fibrillary acidic protein (GFAP) in mice brain tissue and small degenerative alterations in mice liver tissue. The data obtained show mildronate's protective properties in indinavir-induced cardiotoxicity and efavirenz-induced neurotoxicity.

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