Questions and Answers The HPTN 052 Study: Preventing Sexual Transmission of HIV with Anti-HIV Drugs

2011 ◽  
Keyword(s):  
Sexual Transmission ◽  
Questions And Answers ◽  
Sexual Transmission Of Hiv ◽  
Hiv Drugs ◽  
Anti Hiv

3-Hydroxyphthaloyl-β-Lactoglobulin. I. Optimization of Production and Comparison with other Compounds Considered for Chemoprophylaxis of Mucosally Transmitted Human Immunodeficiency Virus Type 1

1997 ◽  
Vol 8 (2) ◽  
pp. 131-139 ◽  
Author(s):  
AR Neurath ◽  
AK Debnath ◽  
N Strick ◽  
Y-Y Li ◽  
K Lin ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiviral Activity ◽  
Chemical Modification ◽  
Elevated Temperatures ◽  
Sexual Transmission ◽  
Immunodeficiency Virus ◽  
Sexual Transmission Of Hiv ◽  
Β Lactoglobulin ◽  
Anti Hiv ◽  
Hiv 1

Modification of the major bovine whey protein, β-lactoglobulin (β-LG) by 3-hydroxyphthalic anhydride (3HP) leads to the generation of a potent inhibitor of infection by human immunodeficiency virus (HIV) types 1 and 2, designated 3HP-β-LG. 3HP-β-LG also has antiviral activity against herpesviruses, albeit at concentrations exceeding those required for inhibition of HIV-1 infection. The topical application of 3HP-β-LG to decrease the rate of sexual transmission of HIV and other sexually transmitted viruses worldwide is being considered. Results presented here: (i) define the conditions for chemical modification of β-LG by 3HP, resulting in 3HP-β-LG with optimum anti-HIV-1 activity; (ii) show that β-LG, prior to chemical modification, or 3HP-β-LG can be exposed to the elevated temperatures used to pasteurize milk without adversely affecting anti-HIV-1 activity; (iii) provide evidence that 3HP-β-LG is a more potent anti-HIV-1 compound than sulphated polysaccharides, other candidate compounds considered as prophylactic agents to prevent sexual transmission of HIV-1; and (iv) confirm that the primary target for 3HP-β-LG is CD4, although binding to the HIV-1 envelope protein gp120 was also observed and contributed to the antiviral activity of 3HP-β-LG.

Two New Anti-HIV Drugs Provide Effective Combo

2005 ◽  
Vol 35 (3) ◽  
pp. 32
Author(s):  
MITCHEL L. ZOLER
Keyword(s):  
Hiv Drugs ◽  
Anti Hiv

Multiscale Mapping of AIDS in U.S. Countries vs Anti-HIV Drugs Activity with Complex Networks and Information Indices

2015 ◽  
Vol 10 (5) ◽  
pp. 639-657 ◽  
Author(s):  
Diana Maria Herrera-Ibata ◽  
Ricardo Alfredo Orbegozo-Medina ◽  
Humberto Gonzalez-Diaz
Keyword(s):  
Complex Networks ◽  
Information Indices ◽  
Hiv Drugs ◽  
Anti Hiv

Lipid Based Nanocarriers for Delivery of Anti-HIV Drugs: A Mini Review

2018 ◽  
Vol 8 (2) ◽  
pp. 172-185
Author(s):  
Diksha Mishra ◽  
Anil B. Jindal
Keyword(s):  
Hiv Drugs ◽  
Anti Hiv
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