scholarly journals Histone Deacetylase Inhibitor Suberanilohydroxamic Acid Treatment Reverses Hyposensitivity to γ-Aminobutyric Acid in the Ventral Tegmental Area During Ethanol Withdrawal

2018 ◽  
Vol 42 (11) ◽  
pp. 2160-2171 ◽  
Author(s):  
Chang You ◽  
Bertha J. Vandegrift ◽  
Huaibo Zhang ◽  
Amy W. Lasek ◽  
Subhash C. Pandey ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Acid Treatment ◽  
Ethanol Withdrawal ◽  
Aminobutyric Acid ◽  
Deacetylase Inhibitor ◽  
Ventral Tegmental

As a Histone Deacetylase Inhibitor, γ‐Aminobutyric Acid Upregulates GluR2 Expression: An In Vitro and In Vivo Study

2019 ◽  
Vol 63 (17) ◽  
pp. 1900001 ◽  
Author(s):  
Aiping Xing ◽  
Xinhui Li ◽  
Congmin Jiang ◽  
Yanqiu Chen ◽  
Sining Wu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Aminobutyric Acid ◽  
In Vivo Study ◽  
Deacetylase Inhibitor

scholarly journals Effect of Histone Deacetylase Inhibitor on Ethanol Withdrawal-Induced Hyperalgesia in Rats

2019 ◽  
Vol 22 (8) ◽  
pp. 523-527 ◽  
Author(s):  
Amynah A Pradhan ◽  
Alycia F Tipton ◽  
Huaibo Zhang ◽  
Areeb Akbari ◽  
Subhash C Pandey
Keyword(s):  
Histone Deacetylase ◽  
Alcohol Withdrawal ◽  
Histone Deacetylase Inhibitor ◽  
Pain Sensitivity ◽  
Histone Deacetylase Inhibitors ◽  
Ethanol Exposure ◽  
Ethanol Withdrawal ◽  
Chronic Ethanol ◽  
Chronic Ethanol Exposure ◽  
Deacetylase Inhibitor

Abstract Background Increased pain sensitivity is observed following alcohol withdrawal, and attempts to alleviate this hyperalgesia can contribute to the cycle of addiction. The aim of this study was to determine if alcohol withdrawal-induced hyperalgesia was observed in a chronic ethanol exposure model and if this pain was affected by histone deacetylase inhibitors, thus revealing an epigenetic mechanism. Methods Adult male Sprague Dawley rats received Lieber-DeCarli liquid control or ethanol (9% v/v) diet for 15 days. Mechanical sensitivity was measured with von Frey hair stimulation of the hindpaw during ethanol administration and 24- and 72-hour withdrawal. Results Ethanol withdrawal produced severe and sustained mechanical hyperalgesia, an effect not observed in the control or ethanol-maintained groups. Furthermore, this hyperalgesia was attenuated by the histone deacetylase inhibitor, suberoylanilide hydroxamic acid treatment. Conclusions Heightened pain sensitivity was observed following withdrawal from chronic ethanol exposure, and histone deacetylase inhibitors could be novel treatments for this alcohol withdrawal-induced hyperalgesia.

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