scholarly journals Hyposensitivity to Gamma-Aminobutyric Acid in the Ventral Tegmental Area During Alcohol Withdrawal: Reversal by Histone Deacetylase Inhibitors

2013 ◽  
Vol 38 (9) ◽  
pp. 1674-1684 ◽  
Author(s):  
Devinder S Arora ◽  
Sudarat Nimitvilai ◽  
Tara L Teppen ◽  
Maureen A McElvain ◽  
Amul J Sakharkar ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Histone Deacetylase ◽  
Alcohol Withdrawal ◽  
Histone Deacetylase Inhibitors ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Ventral Tegmental ◽  
Withdrawal Reversal

The Role of Ventral Tegmental Area Gamma-Aminobutyric Acid in Chronic Neuropathic Pain after Spinal Cord Injury in Rats

2018 ◽  
Vol 35 (15) ◽  
pp. 1755-1764 ◽  
Author(s):  
Moon Yi Ko ◽  
Eun Young Jang ◽  
June Yeon Lee ◽  
Soo Phil Kim ◽  
Sung Hun Whang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Ventral Tegmental Area ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Chronic Neuropathic Pain ◽  
Cord Injury ◽  
Ventral Tegmental

Chronic alcoholism influences the mRNA level of the orexin receptor type 1 (OX1R) in emotiogenic structures of the rat brain

2018 ◽  
Vol 64 (5) ◽  
pp. 451-454 ◽  
Author(s):  
M.I. Airapetov ◽  
E.A. Sekste ◽  
S.O. Eresko ◽  
E.R. Bychkov ◽  
A.A. Lebedev ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Ventral Tegmental Area ◽  
Alcohol Withdrawal ◽  
Alcohol Intoxication ◽  
Mrna Level ◽  
Receptor Type ◽  
Intact Control ◽  
Chronic Alcoholization ◽  
Ventral Tegmental

Orexin and its receptors were shown to be involved into mechanisms of pathological craving to alcohol. This paper demonstrates that the orexin receptor type 1 (OX1R) mRNA level significantly decreased in the prefrontal cortex of rats chronically (during 6 months) consuming ethanol compared with intact control. The same results were observed on day 1 and day 7 of alcohol withdrawal after chronic alcoholization. On the contrary, in the hippocampus, the OX1R mRNA level increased on day 1 and day 7 of alcohol withdrawal. In the ventral tegmental area, the OX1R mRNA level did not change on the day 1 and day 7 of alcohol withdrawal compared with the groups of chronic alcoholization and intact control. These findings point out involvement of the prefrontal cortex and hippocampus first of all in mechanisms mediating chronic alcohol intoxication. The ventral tegmental area is described as a typical dopaminergic structure providing the executive mechanism of emotion reactions connected with alcohol abuse in particular. It is possibe, that the modulating action of orexins on dopaminergic neurons in this structure does not provide a significant effect on control of emotion reactions in alcoholism.

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