scholarly journals Involvement of Purinergic P2X4 Receptors in Alcohol Intake of High-Alcohol-Drinking (HAD) Rats

2015 ◽  
Vol 39 (10) ◽  
pp. 2022-2031 ◽  
Author(s):  
Kelle M. Franklin ◽  
Sheketha R. Hauser ◽  
Amy W. Lasek ◽  
Richard L. Bell ◽  
William J. McBride
Keyword(s):  
Alcohol Drinking ◽  
Alcohol Intake ◽  
High Alcohol ◽  
P2x4 Receptors

scholarly journals Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats

2009 ◽  
Vol 14 (2) ◽  
pp. 152-164 ◽  
Author(s):  
Zachary A. Rodd ◽  
Richard L. Bell ◽  
Kelly A. Kuc ◽  
James M. Murphy ◽  
Lawrence Lumeng ◽  
...  
Keyword(s):  
Alcohol Drinking ◽  
Alcohol Intake ◽  
High Alcohol

scholarly journals Prazosin Reduces Alcohol Drinking Throughout Prolonged Treatment and Blocks the Initiation of Drinking in Rats Selectively Bred for High Alcohol Intake

2013 ◽  
Vol 37 (9) ◽  
pp. 1552-1560 ◽  
Author(s):  
Janice C. Froehlich ◽  
Brett J. Hausauer ◽  
David L. Federoff ◽  
Stephen M. Fischer ◽  
Dennis D. Rasmussen
Keyword(s):  
Alcohol Drinking ◽  
Alcohol Intake ◽  
Prolonged Treatment ◽  
High Alcohol ◽  
High Alcohol Intake

Effect of Mu Opioid Receptor Blockade on Alcohol Intake in Rats Bred for High Alcohol Drinking

1998 ◽  
Vol 59 (3) ◽  
pp. 627-635 ◽  
Author(s):  
S Krishnan-Sarin ◽  
G.S Wand ◽  
X.-W Li ◽  
P.S Portoghese ◽  
J.C Froehlich
Keyword(s):  
Opioid Receptor ◽  
Alcohol Drinking ◽  
Alcohol Intake ◽  
Mu Opioid Receptor ◽  
Receptor Blockade ◽  
High Alcohol ◽  
Mu Opioid

scholarly journals EFFECTS OF ARIPIPRAZOLE ON ALCOHOL INTAKE IN AN ANIMAL MODEL OF HIGH-ALCOHOL DRINKING

2006 ◽  
Vol 41 (4) ◽  
pp. 391-398 ◽  
Author(s):  
KIMMO INGMAN ◽  
JOHANNA KUPILA ◽  
PETRI HYYTIÄ ◽  
ESA R. KORPI
Keyword(s):  
Animal Model ◽  
Alcohol Drinking ◽  
Alcohol Intake ◽  
High Alcohol

scholarly journals Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras

2020 ◽  
Vol 318 (2) ◽  
pp. G265-G276
Author(s):  
Kinji Asahina ◽  
Steven Balog ◽  
Edward Hwang ◽  
Eugene Moon ◽  
Emily Wan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Alcohol Drinking ◽  
Calcium Binding ◽  
Alcohol Intake ◽  
Western Diet ◽  
Mutant Mice ◽  
Ductal Adenocarcinoma ◽  
Moderate Alcohol Intake

Kras mutations are associated with pancreatic ductal adenocarcinoma (PDAC). Although tobacco smoking, pancreatitis, and obesity are known environmental risk factors for PDAC, the contribution of moderate alcohol intake to PDAC remains elusive. In the present study, we tested whether a combination of risk factors or moderate alcohol intake induces PDAC development in mice. Control Pdx1Cre and Pdx1Cre;LSL- KrasG12D mutant mice were fed a Western alcohol diet containing high levels of cholesterol and saturated fat, 3.5% alcohol, and lipopolysaccharide for 5 mo. In addition, mice were treated with cerulein, for induction of pancreatitis, and nicotine every month. Treatment with all of these risk factors promoted development of advanced pancreatic neoplasia and PDAC in the Pdx1Cre;LSL- KrasG12D mice but not in the control Pdx1Cre mice. Moderate alcohol intake or Western diet feeding also significantly promoted advanced neoplasia and PDAC development in Pdx1Cre;LSL- KrasG12D mice compared with mice fed a regular chow. Alcohol, but not Western diet, increased tumor development in the liver in the Pdx1Cre;LSL- KrasG12D mice, but its origin remained elusive due to leakiness of Pdx1Cre in hepatocytes. RNA-seq analysis revealed that alcohol feeding increases expression of markers for tumors ( Epcam, Krt19, Prom1, Wt1, and Wwtr1), stroma ( Dcn, Fn1, and Tnc), and cytokines ( Tgfb1 and Tnf) and decreases expression of Fgf21 and Il6 in the pancreatic tumor tissues. Immunostaining showed heterogeneous expression of nephronectin, S100 calcium-binding protein A6, and vascular cell adhesion molecule 1 in pancreatic tumors surrounded by podoplanin-positive stromal cells. Our data indicate that moderate alcohol drinking is a risk factor for development of PDAC. NEW & NOTEWORTHY Heavy alcohol intake has been suspected to be a risk factor of pancreatic ductal adenocarcinoma (PDAC) in humans. However, the contribution of moderate alcohol intake to PDAC development remains elusive. In the present study, we experimentally show that moderate alcohol feeding significantly induces advanced stages of pancreatic intraepithelial neoplasia development and invasive PDAC in Pdx1Cre;LSL- KrasG12D mutant mice. Our data indicate that moderate alcohol drinking is a risk factor for PDAC.

Ethanol effects on local cerebral glucose utilization in high-alcohol-drinking and low-alcohol-drinking rats

Alcohol ◽  
2003 ◽  
Vol 29 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Jennifer E Learn ◽  
Daniel G Smith ◽  
William J McBride ◽  
Lawrence Lumeng ◽  
Ting-Kai Li
Keyword(s):  
Alcohol Drinking ◽  
Glucose Utilization ◽  
High Alcohol ◽  
Local Cerebral Glucose Utilization ◽  
Cerebral Glucose Utilization ◽  
Low Alcohol
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