Effects of continuous opioid receptor blockade on alcohol intake and up-regulation of opioid receptor subtype signalling in a genetic model of high alcohol drinking

1999 ◽  
Vol 360 (4) ◽  
pp. 391-401 ◽  
Author(s):  
P. Hyytiä ◽  
K. Ingman ◽  
S.L. Soini ◽  
J.T. Laitinen ◽  
E.R. Korpi
Keyword(s):  
Opioid Receptor ◽  
Alcohol Drinking ◽  
Alcohol Intake ◽  
Genetic Model ◽  
Receptor Subtype ◽  
Receptor Blockade ◽  
High Alcohol

Effect of Mu Opioid Receptor Blockade on Alcohol Intake in Rats Bred for High Alcohol Drinking

1998 ◽  
Vol 59 (3) ◽  
pp. 627-635 ◽  
Author(s):  
S Krishnan-Sarin ◽  
G.S Wand ◽  
X.-W Li ◽  
P.S Portoghese ◽  
J.C Froehlich
Keyword(s):  
Opioid Receptor ◽  
Alcohol Drinking ◽  
Alcohol Intake ◽  
Mu Opioid Receptor ◽  
Receptor Blockade ◽  
High Alcohol ◽  
Mu Opioid

scholarly journals Involvement of Purinergic P2X4 Receptors in Alcohol Intake of High-Alcohol-Drinking (HAD) Rats

2015 ◽  
Vol 39 (10) ◽  
pp. 2022-2031 ◽  
Author(s):  
Kelle M. Franklin ◽  
Sheketha R. Hauser ◽  
Amy W. Lasek ◽  
Richard L. Bell ◽  
William J. McBride
Keyword(s):  
Alcohol Drinking ◽  
Alcohol Intake ◽  
High Alcohol ◽  
P2x4 Receptors

scholarly journals Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats

2009 ◽  
Vol 14 (2) ◽  
pp. 152-164 ◽  
Author(s):  
Zachary A. Rodd ◽  
Richard L. Bell ◽  
Kelly A. Kuc ◽  
James M. Murphy ◽  
Lawrence Lumeng ◽  
...  
Keyword(s):  
Alcohol Drinking ◽  
Alcohol Intake ◽  
High Alcohol

scholarly journals Kappa Opioid Receptor and Dynorphin Signaling in the Central Amygdala Regulates Alcohol Intake

2019 ◽  
Author(s):  
Daniel W. Bloodgood ◽  
Dipanwita Pati ◽  
Melanie M. Pina ◽  
Sofia Neira ◽  
J. Andrew Hardaway ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Alcohol Drinking ◽  
Alcohol Intake ◽  
Gene Knockout ◽  
Kappa Opioid Receptor ◽  
Conditional Knockout ◽  
Central Nucleus ◽  
Kappa Opioid ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol

AbstractExcessive alcohol drinking has been shown to modify brain circuitry to predispose individuals for future alcohol abuse. Previous studies have implicated the central nucleus of the amygdala (CeA) as an important site for mediating the somatic symptoms of withdrawal and for regulating alcohol intake. In addition, recent work has established a role for both the Kappa Opioid Receptor (KOR) and its endogenous ligand dynorphin in mediating these processes. However, it is unclear whether these effects are due to dynorphin or KOR arising from within the CeA itself or other input brain regions. To directly examine the role of preprodynorphin (PDYN) and KOR expression in CeA neurons, we performed region-specific conditional knockout of these genes and assessed the effects on the Drinking in the Dark (DID) and Intermittent Access (IA) paradigms. We then examined the effects of DID on PDYN and KOR modulation of CeA circuit physiology. Conditional gene knockout resulted in sex-specific responses wherein PDYN knockout decreased alcohol drinking in both male and female mice, whereas KOR knockout decreased drinking in males only. We also found that neither PDYN nor KOR knockout protected against anxiety caused by alcohol drinking. Lastly, a history of alcohol drinking did not alter synaptic transmission in PDYN neurons in the CeA of either sex, but excitability of PDYN neurons was increased in male mice only. Taken together, our findings indicate that PDYN and KOR signaling in the CeA plays an important role in regulating excessive alcohol consumption and highlight the need for future studies to examine how this is mediated through downstream effector regions.

scholarly journals Prazosin Reduces Alcohol Drinking Throughout Prolonged Treatment and Blocks the Initiation of Drinking in Rats Selectively Bred for High Alcohol Intake

2013 ◽  
Vol 37 (9) ◽  
pp. 1552-1560 ◽  
Author(s):  
Janice C. Froehlich ◽  
Brett J. Hausauer ◽  
David L. Federoff ◽  
Stephen M. Fischer ◽  
Dennis D. Rasmussen
Keyword(s):  
Alcohol Drinking ◽  
Alcohol Intake ◽  
Prolonged Treatment ◽  
High Alcohol ◽  
High Alcohol Intake

scholarly journals EFFECTS OF ARIPIPRAZOLE ON ALCOHOL INTAKE IN AN ANIMAL MODEL OF HIGH-ALCOHOL DRINKING

2006 ◽  
Vol 41 (4) ◽  
pp. 391-398 ◽  
Author(s):  
KIMMO INGMAN ◽  
JOHANNA KUPILA ◽  
PETRI HYYTIÄ ◽  
ESA R. KORPI
Keyword(s):  
Animal Model ◽  
Alcohol Drinking ◽  
Alcohol Intake ◽  
High Alcohol
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