scholarly journals Neural Firing in the Prefrontal Cortex During Alcohol Intake in Alcohol-Preferring “P” Versus Wistar Rats

2015 ◽  
Vol 39 (9) ◽  
pp. 1642-1653 ◽  
Author(s):  
David N. Linsenbardt ◽  
Christopher C. Lapish
Keyword(s):  
Prefrontal Cortex ◽  
Wistar Rats ◽  
Alcohol Intake ◽  
Neural Firing

scholarly journals Encoding of the Intent to Drink Alcohol by the Prefrontal Cortex is blunted in Rats with a Family History of Excessive Drinking

2018 ◽  
Author(s):  
David N. Linsenbardt ◽  
Nicholas M. Timme ◽  
Christopher C. Lapish
Keyword(s):  
Prefrontal Cortex ◽  
Neural Activity ◽  
Alcohol Drinking ◽  
Wistar Rats ◽  
Alcohol Intake ◽  
Activity Patterns ◽  
Excessive Drinking ◽  
Lack Of Control ◽  
History Of ◽  
Excessive Alcohol

The prefrontal cortex plays a central role in guiding decision-making, and its function is altered by alcohol use and an individual’s innate risk for excessive alcohol drinking. The primary goal of this work was to determine how neural activity in the prefrontal cortex guides the decision to drink. Towards this goal, the within-session changes in neural activity were measured from medial prefrontal cortex (mPFC) of rats performing a drinking procedure that allowed them to consume or abstain from alcohol in a self-paced manner. Recordings were obtained from rats that either lacked or expressed an innate risk for excessive alcohol intake - Wistar or Alcohol Preferring ‘P’ rats, respectively. Wistar rats exhibited patterns of neural activity consistent with the intention to drink or abstain from drinking, whereas these patterns were blunted or absent in P rats. Collectively, these data indicate that neural activity patterns in mPFC associated with the intention to drink alcohol are influenced by innate risk for excessive alcohol drinking. This observation may indicate a lack of control over the decision to drink by this otherwise well-validated supervisory brain region.

The role of prefrontal cortex dopamine D2 and D3 receptors in the mechanism of action of venlafaxine and deep brain stimulation in animal models of treatment-responsive and treatment-resistant depression

2019 ◽  
Vol 33 (6) ◽  
pp. 748-756 ◽  
Author(s):  
Mariusz Papp ◽  
Piotr Gruca ◽  
Magdalena Lason ◽  
Monika Niemczyk ◽  
Paul Willner
Keyword(s):  
Prefrontal Cortex ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Memory Consolidation ◽  
Wistar Rats ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Wistar Kyoto Rats ◽  
Wistar Kyoto ◽  
Deep Brain

Aims: The Wistar-Kyoto rat has been validated as an animal model of treatment-resistant depression. Here we investigated a role of dopamine D2 and D3 receptors in the ventro-medial prefrontal cortex in the mechanism of action of deep brain stimulation in Wistar-Kyoto rats and venlafaxine in Wistar rats. Methods: Wistar or Wistar-Kyoto rats were exposed chronically to chronic mild stress. Wistar rats were treated chronically with venlafaxine (10 mg/kg) beginning after two weeks of chronic mild stress; Wistar-Kyoto rats received two sessions of deep brain stimulation before behavioural tests. L-742,626 (1 µg), a D2 receptor agonist, or 7-OH DPAT (3 µg), a D3 receptor antagonist, were infused into the ventro-medial prefrontal cortex immediately following the exposure trial in the Novel Object Recognition Test, and discrimination between novel and familiar object was tested one hour later. Results: Chronic mild stress decreased sucrose intake and impaired memory consolidation; these effects were reversed by venlafaxine in Wistar rats and deep brain stimulation in Wistar-Kyoto rats. In control animals, L-742,626 and 7-OH DPAT also impaired memory consolidation. In Wistar rats, venlafaxine reversed the effect of L-742,626 in controls, but not in the chronic mild stress group, and venlafaxine did not reverse the effect of 7-OH DPAT in either group. In Wistar-Kyoto rats, deep brain stimulation reversed the effect of both L-742,626 and 7-OH DPAT in both control and chronic mild stress groups. Conclusions: We conclude that the action of venlafaxine to reverse the impairment of memory consolidation caused by chronic mild stress in Wistar rats involves D2 receptors in the ventro-medial prefrontal cortex; but the effect of deep brain stimulation to reverse the same effect in Wistar-Kyoto rats does not.

Behavioral and stereological analysis of the prefrontal cortex of rats submitted to chronic alcohol intake

2019 ◽  
Vol 362 ◽  
pp. 21-27 ◽  
Author(s):  
Rafael Conte ◽  
Fernando Vagner Lobo Ladd ◽  
Aliny Antunes Barbosa Lobo Ladd ◽  
Amanda Lopez Moreira ◽  
Luciana Le Sueur-Maluf ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Alcohol Intake ◽  
Chronic Alcohol ◽  
Stereological Analysis

Extracellular dopamine levels are lower in the medial prefrontal cortex of alcohol-preferring rats compared to Wistar rats

Alcohol ◽  
2006 ◽  
Vol 38 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Eric A. Engleman ◽  
Cynthia M. Ingraham ◽  
William J. McBride ◽  
Lawrence Lumeng ◽  
James M. Murphy
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Wistar Rats ◽  
Extracellular Dopamine

Genetic, sex, and early environmental effects on the voluntary alcohol intake in Wistar rats

2000 ◽  
Vol 67 (4) ◽  
pp. 801-808 ◽  
Author(s):  
F. Sluyter ◽  
M. Hof ◽  
B.A. Ellenbroek ◽  
S.B. Degen ◽  
A.R. Cools
Keyword(s):  
Environmental Effects ◽  
Wistar Rats ◽  
Alcohol Intake

scholarly journals Effect of Electronic Cigarette on Brain Prefrontal Cortex of Male Wistar Rats

2020 ◽  
Vol 6 (3) ◽  
pp. 98-102
Author(s):  
Centaury Noor Kuncorowati ◽  
◽  
Sofia Mawaddatul Urfah ◽  
Devanico Yuangga Duta Maulana ◽  
Mochamad Bahrudin ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Wistar Rats ◽  
Electronic Cigarette ◽  
Male Wistar Rats
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