scholarly journals Neural Firing in the Prefrontal Cortex During Alcohol Intake in Alcohol-Preferring “P” Versus Wistar Rats

2015 ◽  
Vol 39 (9) ◽  
pp. 1642-1653 ◽  
Author(s):  
David N. Linsenbardt ◽  
Christopher C. Lapish
2018 ◽  
Author(s):  
David N. Linsenbardt ◽  
Nicholas M. Timme ◽  
Christopher C. Lapish

The prefrontal cortex plays a central role in guiding decision-making, and its function is altered by alcohol use and an individual’s innate risk for excessive alcohol drinking. The primary goal of this work was to determine how neural activity in the prefrontal cortex guides the decision to drink. Towards this goal, the within-session changes in neural activity were measured from medial prefrontal cortex (mPFC) of rats performing a drinking procedure that allowed them to consume or abstain from alcohol in a self-paced manner. Recordings were obtained from rats that either lacked or expressed an innate risk for excessive alcohol intake - Wistar or Alcohol Preferring ‘P’ rats, respectively. Wistar rats exhibited patterns of neural activity consistent with the intention to drink or abstain from drinking, whereas these patterns were blunted or absent in P rats. Collectively, these data indicate that neural activity patterns in mPFC associated with the intention to drink alcohol are influenced by innate risk for excessive alcohol drinking. This observation may indicate a lack of control over the decision to drink by this otherwise well-validated supervisory brain region.


2019 ◽  
Vol 33 (6) ◽  
pp. 748-756 ◽  
Author(s):  
Mariusz Papp ◽  
Piotr Gruca ◽  
Magdalena Lason ◽  
Monika Niemczyk ◽  
Paul Willner

Aims: The Wistar-Kyoto rat has been validated as an animal model of treatment-resistant depression. Here we investigated a role of dopamine D2 and D3 receptors in the ventro-medial prefrontal cortex in the mechanism of action of deep brain stimulation in Wistar-Kyoto rats and venlafaxine in Wistar rats. Methods: Wistar or Wistar-Kyoto rats were exposed chronically to chronic mild stress. Wistar rats were treated chronically with venlafaxine (10 mg/kg) beginning after two weeks of chronic mild stress; Wistar-Kyoto rats received two sessions of deep brain stimulation before behavioural tests. L-742,626 (1 µg), a D2 receptor agonist, or 7-OH DPAT (3 µg), a D3 receptor antagonist, were infused into the ventro-medial prefrontal cortex immediately following the exposure trial in the Novel Object Recognition Test, and discrimination between novel and familiar object was tested one hour later. Results: Chronic mild stress decreased sucrose intake and impaired memory consolidation; these effects were reversed by venlafaxine in Wistar rats and deep brain stimulation in Wistar-Kyoto rats. In control animals, L-742,626 and 7-OH DPAT also impaired memory consolidation. In Wistar rats, venlafaxine reversed the effect of L-742,626 in controls, but not in the chronic mild stress group, and venlafaxine did not reverse the effect of 7-OH DPAT in either group. In Wistar-Kyoto rats, deep brain stimulation reversed the effect of both L-742,626 and 7-OH DPAT in both control and chronic mild stress groups. Conclusions: We conclude that the action of venlafaxine to reverse the impairment of memory consolidation caused by chronic mild stress in Wistar rats involves D2 receptors in the ventro-medial prefrontal cortex; but the effect of deep brain stimulation to reverse the same effect in Wistar-Kyoto rats does not.


2019 ◽  
Vol 362 ◽  
pp. 21-27 ◽  
Author(s):  
Rafael Conte ◽  
Fernando Vagner Lobo Ladd ◽  
Aliny Antunes Barbosa Lobo Ladd ◽  
Amanda Lopez Moreira ◽  
Luciana Le Sueur-Maluf ◽  
...  

Alcohol ◽  
2006 ◽  
Vol 38 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Eric A. Engleman ◽  
Cynthia M. Ingraham ◽  
William J. McBride ◽  
Lawrence Lumeng ◽  
James M. Murphy

2000 ◽  
Vol 67 (4) ◽  
pp. 801-808 ◽  
Author(s):  
F. Sluyter ◽  
M. Hof ◽  
B.A. Ellenbroek ◽  
S.B. Degen ◽  
A.R. Cools

2020 ◽  
Vol 6 (3) ◽  
pp. 98-102
Author(s):  
Centaury Noor Kuncorowati ◽  
◽  
Sofia Mawaddatul Urfah ◽  
Devanico Yuangga Duta Maulana ◽  
Mochamad Bahrudin ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document