scholarly journals Cytological and histochemical study of the prefrontal cortex and hippocampus after treatment with extract of jatropha tanjorensis in wistar rats

IBRO Reports ◽  
2019 ◽  
Vol 7 ◽  
pp. 29
Author(s):  
I.F. Bassey ◽  
N.J. Obosi ◽  
A.O. Akpantah
Keyword(s):  
Prefrontal Cortex ◽  
Wistar Rats ◽  
Histochemical Study

The role of prefrontal cortex dopamine D2 and D3 receptors in the mechanism of action of venlafaxine and deep brain stimulation in animal models of treatment-responsive and treatment-resistant depression

2019 ◽  
Vol 33 (6) ◽  
pp. 748-756 ◽  
Author(s):  
Mariusz Papp ◽  
Piotr Gruca ◽  
Magdalena Lason ◽  
Monika Niemczyk ◽  
Paul Willner
Keyword(s):  
Prefrontal Cortex ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Memory Consolidation ◽  
Wistar Rats ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Wistar Kyoto Rats ◽  
Wistar Kyoto ◽  
Deep Brain

Aims: The Wistar-Kyoto rat has been validated as an animal model of treatment-resistant depression. Here we investigated a role of dopamine D2 and D3 receptors in the ventro-medial prefrontal cortex in the mechanism of action of deep brain stimulation in Wistar-Kyoto rats and venlafaxine in Wistar rats. Methods: Wistar or Wistar-Kyoto rats were exposed chronically to chronic mild stress. Wistar rats were treated chronically with venlafaxine (10 mg/kg) beginning after two weeks of chronic mild stress; Wistar-Kyoto rats received two sessions of deep brain stimulation before behavioural tests. L-742,626 (1 µg), a D2 receptor agonist, or 7-OH DPAT (3 µg), a D3 receptor antagonist, were infused into the ventro-medial prefrontal cortex immediately following the exposure trial in the Novel Object Recognition Test, and discrimination between novel and familiar object was tested one hour later. Results: Chronic mild stress decreased sucrose intake and impaired memory consolidation; these effects were reversed by venlafaxine in Wistar rats and deep brain stimulation in Wistar-Kyoto rats. In control animals, L-742,626 and 7-OH DPAT also impaired memory consolidation. In Wistar rats, venlafaxine reversed the effect of L-742,626 in controls, but not in the chronic mild stress group, and venlafaxine did not reverse the effect of 7-OH DPAT in either group. In Wistar-Kyoto rats, deep brain stimulation reversed the effect of both L-742,626 and 7-OH DPAT in both control and chronic mild stress groups. Conclusions: We conclude that the action of venlafaxine to reverse the impairment of memory consolidation caused by chronic mild stress in Wistar rats involves D2 receptors in the ventro-medial prefrontal cortex; but the effect of deep brain stimulation to reverse the same effect in Wistar-Kyoto rats does not.

Extracellular dopamine levels are lower in the medial prefrontal cortex of alcohol-preferring rats compared to Wistar rats

Alcohol ◽  
2006 ◽  
Vol 38 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Eric A. Engleman ◽  
Cynthia M. Ingraham ◽  
William J. McBride ◽  
Lawrence Lumeng ◽  
James M. Murphy
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Wistar Rats ◽  
Extracellular Dopamine

scholarly journals Effect of Electronic Cigarette on Brain Prefrontal Cortex of Male Wistar Rats

2020 ◽  
Vol 6 (3) ◽  
pp. 98-102
Author(s):  
Centaury Noor Kuncorowati ◽  
◽  
Sofia Mawaddatul Urfah ◽  
Devanico Yuangga Duta Maulana ◽  
Mochamad Bahrudin ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Wistar Rats ◽  
Electronic Cigarette ◽  
Male Wistar Rats

scholarly journals Immunohistochemical studies of codeine medication on the prefrontal cortex and cerebellum of adult Wistar rats

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Victor B. Archibong ◽  
Theresa B. Ekanem ◽  
Anozeng O. Igiri ◽  
Ann M. Lemuel ◽  
Ibe M. Usman ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Wistar Rats ◽  
Immunohistochemical Studies

Treadmill exercise induces age and protocol-dependent epigenetic changes in prefrontal cortex of Wistar rats

2016 ◽  
Vol 313 ◽  
pp. 82-87 ◽  
Author(s):  
Laura Reck Cechinel ◽  
Carla Giovana Basso ◽  
Karine Bertoldi ◽  
Bruna Schallenberger ◽  
Louisiana Carolina Ferreira de Meireles ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Wistar Rats ◽  
Treadmill Exercise ◽  
Epigenetic Changes
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