scholarly journals Prolonged quiescence delays somatic stem cell‐like divisions in Caenorhabditis elegans and is controlled by insulin signaling

Aging Cell ◽  
2019 ◽  
Vol 19 (2) ◽  
Author(s):  
María Olmedo ◽  
Alejandro Mata‐Cabana ◽  
María Jesús Rodríguez‐Palero ◽  
Sabas García‐Sánchez ◽  
Antonio Fernández‐Yañez ◽  
...  
Keyword(s):  
Stem Cell ◽  
Caenorhabditis Elegans ◽  
Insulin Signaling ◽  
Somatic Stem Cell

scholarly journals A role for the fusogen eff-1 in epidermal stem cell number robustness in Caenorhabditis elegans

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sneha L. Koneru ◽  
Fu Xiang Quah ◽  
Ritobrata Ghose ◽  
Mark Hintze ◽  
Nicola Gritti ◽  
...  
Keyword(s):  
Stem Cell ◽  
Caenorhabditis Elegans ◽  
Cell Fate ◽  
Single Molecule ◽  
Phenotypic Variability ◽  
Low Frequency ◽  
Time Lapse ◽  
Cell Number ◽  
Seam Cell ◽  
Neuronal Tissues

AbstractDevelopmental patterning in Caenorhabditis elegans is known to proceed in a highly stereotypical manner, which raises the question of how developmental robustness is achieved despite the inevitable stochastic noise. We focus here on a population of epidermal cells, the seam cells, which show stem cell-like behaviour and divide symmetrically and asymmetrically over post-embryonic development to generate epidermal and neuronal tissues. We have conducted a mutagenesis screen to identify mutants that introduce phenotypic variability in the normally invariant seam cell population. We report here that a null mutation in the fusogen eff-1 increases seam cell number variability. Using time-lapse microscopy and single molecule fluorescence hybridisation, we find that seam cell division and differentiation patterns are mostly unperturbed in eff-1 mutants, indicating that cell fusion is uncoupled from the cell differentiation programme. Nevertheless, seam cell losses due to the inappropriate differentiation of both daughter cells following division, as well as seam cell gains through symmetric divisions towards the seam cell fate were observed at low frequency. We show that these stochastic errors likely arise through accumulation of defects interrupting the continuity of the seam and changing seam cell shape, highlighting the role of tissue homeostasis in suppressing phenotypic variability during development.

scholarly journals Polycomb Group Genes Psc and Su(z)2 Maintain Somatic Stem Cell Identity and Activity in Drosophila

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52892 ◽  
Author(s):  
Jose Rafael Morillo Prado ◽  
Xin Chen ◽  
Margaret T. Fuller
Keyword(s):  
Stem Cell ◽  
Polycomb Group ◽  
Somatic Stem Cell ◽  
Cell Identity ◽  
Polycomb Group Genes

scholarly journals A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication

Development ◽  
2014 ◽  
Vol 141 (8) ◽  
pp. 1767-1779 ◽  
Author(s):  
W. L. Hung ◽  
Y. Wang ◽  
J. Chitturi ◽  
M. Zhen
Keyword(s):  
Caenorhabditis Elegans ◽  
Insulin Signaling ◽  
Developmental Decision

scholarly journals Insulin Signaling Deficiency Produces Immobility in Caenorhabditis elegans That Models Diminished Motivation States in Man and Responds to Antidepressants

2017 ◽  
Vol 3 (2) ◽  
pp. 97-107 ◽  
Author(s):  
Julie Dagenhardt ◽  
Angeline Trinh ◽  
Halen Sumner ◽  
Jeffrey Scott ◽  
Eric Aamodt ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Insulin Signaling
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