scholarly journals Insulin Signaling Deficiency Produces Immobility in Caenorhabditis elegans That Models Diminished Motivation States in Man and Responds to Antidepressants

2017 ◽  
Vol 3 (2) ◽  
pp. 97-107 ◽  
Author(s):  
Julie Dagenhardt ◽  
Angeline Trinh ◽  
Halen Sumner ◽  
Jeffrey Scott ◽  
Eric Aamodt ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Insulin Signaling

scholarly journals A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication

Development ◽  
2014 ◽  
Vol 141 (8) ◽  
pp. 1767-1779 ◽  
Author(s):  
W. L. Hung ◽  
Y. Wang ◽  
J. Chitturi ◽  
M. Zhen
Keyword(s):  
Caenorhabditis Elegans ◽  
Insulin Signaling ◽  
Developmental Decision

scholarly journals Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs

2007 ◽  
Vol 303 (2) ◽  
pp. 434-447 ◽  
Author(s):  
Wendy B. Iser ◽  
Minaxi S. Gami ◽  
Catherine A. Wolkow
Keyword(s):  
Caenorhabditis Elegans ◽  
Insulin Signaling

scholarly journals DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood in Caenorhabditis elegans

2020 ◽  
Vol 10 (5) ◽  
pp. 1521-1539 ◽  
Author(s):  
Daniel R. McHugh ◽  
Elena Koumis ◽  
Paul Jacob ◽  
Jennifer Goldfarb ◽  
Michelle Schlaubitz-Garcia ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Immune System ◽  
Caenorhabditis Elegans ◽  
Host Defense ◽  
Insulin Signaling ◽  
Bacterial Pathogens ◽  
C Elegans ◽  
Link Type ◽  
Age Dependent ◽  
Over Time

Aging is accompanied by a progressive decline in immune function termed “immunosenescence”. Deficient surveillance coupled with the impaired function of immune cells compromises host defense in older animals. The dynamic activity of regulatory modules that control immunity appears to underlie age-dependent modifications to the immune system. In the roundworm Caenorhabditis elegans levels of PMK-1 p38 MAP kinase diminish over time, reducing the expression of immune effectors that clear bacterial pathogens. Along with the PMK-1 pathway, innate immunity in C. elegans is regulated by the insulin signaling pathway. Here we asked whether DAF-16, a Forkhead box (FOXO) transcription factor whose activity is inhibited by insulin signaling, plays a role in host defense later in life. While in younger C. elegansDAF-16 is inactive unless stimulated by environmental insults, we found that even in the absence of acute stress the transcriptional activity of DAF-16 increases in an age-dependent manner. Beginning in the reproductive phase of adulthood, DAF-16 upregulates a subset of its transcriptional targets, including genes required to kill ingested microbes. Accordingly, DAF-16 has little to no role in larval immunity, but functions specifically during adulthood to confer resistance to bacterial pathogens. We found that DAF-16-mediated immunity in adults requires SMK-1, a regulatory subunit of the PP4 protein phosphatase complex. Our data suggest that as the function of one branch of the innate immune system of C. elegans (PMK-1) declines over time, DAF-16-mediated immunity ramps up to become the predominant means of protecting adults from infection, thus reconfiguring immunity later in life.

scholarly journals Cinnamomum cassia Bark in Two Herbal Formulas Increases Life Span in Caenorhabditis elegans via Insulin Signaling and Stress Response Pathways

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9339 ◽  
Author(s):  
Young-Beob Yu ◽  
Laura Dosanjh ◽  
Lixing Lao ◽  
Ming Tan ◽  
Bum Sang Shim ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Stress Response ◽  
Life Span ◽  
Insulin Signaling ◽  
Cinnamomum Cassia

scholarly journals Electrophysiological Measures of Aging Pharynx Function in C. elegans Reveal Enhanced Organ Functionality in Older, Long-lived Mutants

2017 ◽  
Vol 74 (8) ◽  
pp. 1173-1179 ◽  
Author(s):  
Joshua Coulter Russell ◽  
Nikolay Burnaevskiy ◽  
Bridget Ma ◽  
Miguel Arenas Mailig ◽  
Franklin Faust ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Heat Shock ◽  
Life Span ◽  
Insulin Signaling ◽  
Model System ◽  
Wild Type ◽  
Organ Function ◽  
C Elegans ◽  
Age Related ◽  
The Relationship

Abstract The function of the pharynx, an organ in the model system Caenorhabditis elegans, has been correlated with life span and motility (another measure of health) since 1980. In this study, in order to further understand the relationship between organ function and life span, we measured the age-related decline of the pharynx using an electrophysiological approach. We measured and analyzed electropharyngeograms (EPG) of wild type animals, short-lived hsf-1 mutants, and long-lived animals with genetically decreased insulin signaling or increased heat shock pathway signaling; we recorded a total of 2,478 EPGs from 1,374 individuals. As expected, the long-lived daf-2(e1370) and hsf-1OE(uthIs235) animals maintained pharynx function relatively closer to the youthful state during aging, whereas the hsf-1(sy441) and wild type animals’ pharynx function deviated significantly further from the youthful state at advanced age. Measures of the amount of variation in organ function can act as biomarkers of youthful physiology as well. Intriguingly, the long-lived animals had greater variation in the duration of pharynx contraction at older ages.

scholarly journals Clozapine Interaction with Phosphatidyl Inositol 3-Kinase (PI3K)/Insulin-Signaling Pathway in Caenorhabditis elegans

2009 ◽  
Vol 34 (8) ◽  
pp. 1968-1978 ◽  
Author(s):  
Rakesh Karmacharya ◽  
Gregory R Sliwoski ◽  
Miriam Y Lundy ◽  
Raymond F Suckow ◽  
Bruce M Cohen ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Signaling Pathway ◽  
Insulin Signaling ◽  
Phosphatidyl Inositol ◽  
Insulin Signaling Pathway
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