scholarly journals Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle‐age period

Aging Cell ◽  
2016 ◽  
Vol 15 (4) ◽  
pp. 725-736 ◽  
Author(s):  
Mandi J. Corenblum ◽  
Sneha Ray ◽  
Quentin W. Remley ◽  
Min Long ◽  
Bryan Harder ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Function ◽  
Middle Age ◽  
Nrf2 Expression

scholarly journals Enhanced NRF2 expression mitigates the decline in neural stem cell function during aging

Aging Cell ◽  
2021 ◽  
Author(s):  
Annadurai Anandhan ◽  
Konner R. Kirwan ◽  
Mandi J. Corenblum ◽  
Lalitha Madhavan
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Function ◽  
Nrf2 Expression

scholarly journals A Role for Nrf2 Expression in Defining the Aging of Hippocampal Neural Stem Cells

2018 ◽  
Vol 27 (4) ◽  
pp. 589-606 ◽  
Author(s):  
S. Ray ◽  
M. J. Corenblum ◽  
A. Anandhan ◽  
A. Reed ◽  
F. O. Ortiz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Subventricular Zone ◽  
Redox Regulation ◽  
Cell Function ◽  
Middle Age ◽  
Pattern Separation ◽  
Age Related ◽  
Nrf2 Knockout ◽  
Nrf2 Expression

Redox mechanisms are emerging as essential to stem cell function given their capacity to influence a number of important signaling pathways governing stem cell survival and regenerative activity. In this context, our recent work identified the reduced expression of nuclear factor (erythroid-derived 2)-like 2, or Nrf2, in mediating the decline in subventricular zone neural stem progenitor cell (NSPC) regeneration during aging. Since Nrf2 is a major transcription factor at the heart of cellular redox regulation and homeostasis, the current study investigates the role that it may play in the aging of NSPCs that reside within the other major mammalian germinal niche located in the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus. Using rats from multiple aging stages ranging from newborn to old age, and aging Nrf2 knockout mice, we first determined that, in contrast with subventricular zone (SVZ) NSPCs, Nrf2 expression does not significantly affect overall DG NSPC viability with age. However, DG NSPCs resembled SVZ stem cells, in that Nrf2 expression controlled their proliferation and the balance of neuronal versus glial differentiation particularly in relation to a specific critical period during middle age. Also, importantly, this Nrf2-based control of NSPC regeneration was found to impact functional neurogenesis-related hippocampal behaviors, particularly in the Morris water maze and in pattern separation tasks. Furthermore, the enrichment of the hippocampal environment via the transplantation of Nrf2-overexpressing NSPCs was able to mitigate the age-related decline in DG stem cell regeneration during the critical middle-age period, and significantly improved pattern separation abilities. In summary, these results emphasize the importance of Nrf2 in DG NSPC regeneration, and support Nrf2 upregulation as a potential approach to advantageously modulate DG NSPC activity with age.

scholarly journals Roles for HIF-1α in neural stem cell function and the regenerative response to stroke

2012 ◽  
Vol 227 (2) ◽  
pp. 410-417 ◽  
Author(s):  
Lee Anna Cunningham ◽  
Kate Candelario ◽  
Lu Li
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Function ◽  
Regenerative Response

scholarly journals Single-Cell Transcriptomics and Fate Mapping of Ependymal Cells Reveals an Absence of Neural Stem Cell Function

Cell ◽  
2018 ◽  
Vol 173 (4) ◽  
pp. 1045-1057.e9 ◽  
Author(s):  
Prajay T. Shah ◽  
Jo A. Stratton ◽  
Morgan Gail Stykel ◽  
Sepideh Abbasi ◽  
Sandeep Sharma ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Cell ◽  
Neural Stem Cell ◽  
Cell Function ◽  
Ependymal Cells ◽  
Fate Mapping

Precise Design Strategy Of  Smart Extracellular Matrix Based on CRISPR/Cas9 for Regulating Neural Stem Cell Function

2021 ◽  
Author(s):  
Yuanxin Zhai ◽  
Lingyan Yang ◽  
Wenlong Zheng ◽  
Quanwei Wang ◽  
Zhanchi Zhu ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Function ◽  
Design Strategy

Overcoming the Aging Systemic Milieu to Restore Neural Stem Cell Function

2011 ◽  
Vol 14 (6) ◽  
pp. 681-684 ◽  
Author(s):  
Andrew R. Mendelsohn ◽  
James W. Larrick
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Function

Abstract PR15: Acting at a distance: Medulloblastoma-secreted ligands disrupt normal neural stem cell function

2020 ◽  
Author(s):  
Alexander Gont ◽  
Jaclin V. Simonetta ◽  
Jenna Park ◽  
Alice R. Shan ◽  
Michael J. Borrett ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Function
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