Age‐associated outcomes after survived out‐of‐hospital cardiac arrest and subsequent target temperature management

2019 ◽  
Vol 63 (8) ◽  
pp. 1079-1088
Author(s):  
Toni Pätz ◽  
Katharina Stelzig ◽  
Rüdiger Pfeifer ◽  
Undine Pittl ◽  
Holger Thiele ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Temperature Management ◽  
Target Temperature Management ◽  
Target Temperature ◽  
Hospital Cardiac Arrest ◽  
Subsequent Target

Cognitive Function in Survivors of Out-of-Hospital Cardiac Arrest After Target Temperature Management at 33°C Versus 36°C

Circulation ◽  
2015 ◽  
Vol 131 (15) ◽  
pp. 1340-1349 ◽  
Author(s):  
Gisela Lilja ◽  
Niklas Nielsen ◽  
Hans Friberg ◽  
Janneke Horn ◽  
Jesper Kjaergaard ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cognitive Function ◽  
Temperature Management ◽  
Target Temperature Management ◽  
Target Temperature ◽  
Hospital Cardiac Arrest

scholarly journals Does Combining Biomarkers and Brain Images Provide Improved Prognostic Predictive Performance for Out-Of-Hospital Cardiac Arrest Survivors before Target Temperature Management?

2020 ◽  
Vol 9 (3) ◽  
pp. 744 ◽  
Author(s):  
Seung Ha Son ◽  
In Ho Lee ◽  
Jung Soo Park ◽  
In Sool Yoo ◽  
Seung Whan Kim ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Neuron Specific Enolase ◽  
Area Under The Curve ◽  
Temperature Management ◽  
Target Temperature Management ◽  
High Signal ◽  
Target Temperature ◽  
Brain Images ◽  
Prognostic Performance ◽  
Hospital Cardiac Arrest

We examined whether combining biomarkers measurements and brain images early after the return of spontaneous circulation improves prognostic performance compared with the use of either biomarkers or brain images for patients with cardiac arrest following target temperature management (TTM). This retrospective observational study involved comatose out-of-hospital cardiac arrest survivors. We analyzed neuron-specific enolase levels in serum (NSE) or cerebrospinal fluid (CSF), grey-to-white matter ratio by brain computed tomography, presence of high signal intensity (HSI) in diffusion-weighted imaging (DWI), and voxel-based apparent diffusion coefficient (ADC). Of the 58 patients, 33 (56.9%) had poor neurologic outcomes. CSF NSE levels showed better prognostic performance (area under the curve (AUC) 0.873, 95% confidence interval (CI) 0.749–0.950) than serum NSE levels (AUC 0.792, 95% CI 0.644–0.888). HSI in DWI showed the best prognostic performance (AUC 0.833, 95% CI 0.711–0.919). Combining CSF NSE levels and HSI in DWI had better prognostic performance (AUC 0.925, 95% CI 0.813–0.981) than each individual method, followed by the combination of serum NSE levels and HSI on DWI and that of CSF NSE levels and the percentage of voxels of ADC (AUC 0.901, 95% CI 0.792–0.965; AUC 0.849, 95% CI 0.717–0.935, respectively). Combining CSF/serum NSE levels and HSI in DWI before TTM improved the prognostic performance compared to either each individual method or other combinations.

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