Trapping and dynamic manipulation of magnetic contrast agent targeted cancer cells in photoacoustic imaging: Phantom study

Author(s):  
Chenwei Wei ◽  
Jinjun Xia ◽  
Ivan Mihaylovich Pelivanov ◽  
Xiaoge Hu ◽  
Xiaohu Gao ◽  
...  
2011 ◽  
Author(s):  
Congxian Jia ◽  
Jinjun Xia ◽  
Ivan M. Pelivanov ◽  
Chi Hyung Seo ◽  
Xiaoge Hu ◽  
...  

RSC Advances ◽  
2017 ◽  
Vol 7 (56) ◽  
pp. 35027-35037 ◽  
Author(s):  
Thi Tuong Vy Phan ◽  
Subramaniyan Bharathiraja ◽  
Van Tu Nguyen ◽  
Madhappan Santha Moorthy ◽  
Panchanathan Manivasagan ◽  
...  

A novel contrast agent with broad NIR absorbing properties for combined photo-induced therapy and photoacoustic imaging.


2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Milad Yousefvand ◽  
Zahra Mohammadi ◽  
Farzaneh Ghorbani ◽  
Rasoul Irajirad ◽  
Hormoz Abedi ◽  
...  

In recent years, the conjugation of superparamagnetic iron oxide nanoparticles (SPIONs), as tumor-imaging probes for magnetic resonance imaging (MRI), with tumor targeting peptides possesses promising advantages for specific delivery of MRI agents. The objective of the current study was to design a targeted contrast agent for MRI based on Fe3O4 nanoparticles conjugated triptorelin (SPION@triptorelin), which has a great affinity to the GnRH receptors. The SPIONs-coated carboxymethyl dextran (SPION@CMD) conjugated triptorelin (SPION@CMD@triptorelin) were synthesized using coprecipitation method and characterized by DLS, TEM, XRD, FTIR, Zeta, and VSM techniques. The relaxivities of synthetized formulations were then calculated using a 1.5 Tesla clinical magnetic field. MRI, quantitative cellular uptake, and cytotoxicity level of them were estimated. The characterization results confirmed that the formation of SPION@CMD@triptorelin has been conjugated with a suitable size. Our results demonstrated the lack of cellular cytotoxicity of SPION@CMD@triptorelin, and it could increase the cellular uptake of SPIONs to MDA-MB-231 cancer cells 6.50-fold greater than to SPION@CMD at the concentration of 75 μM. The relaxivity calculations for SPION@CMD@triptorelin showed a suitable r2 and r2/r1 with values of 31.75 mM−1·s−1 and 10.26, respectively. Our findings confirm that triptorelin-targeted SPIONs could provide a T2-weighted probe contrast agent that has the great potential for the diagnosis of GnRH-positive cancer in MRI.


2020 ◽  
Vol 47 (2) ◽  
pp. 0207033
Author(s):  
于静文 Yu Jingwen ◽  
王秀翃 Wang Xiuhong ◽  
冯金超 Feng Jinchao ◽  
张娜 Zhang Na ◽  
王璞 Wang Pu

2020 ◽  
Vol 56 (46) ◽  
pp. 6281-6284 ◽  
Author(s):  
Changjin Ou ◽  
Yewei Zhang ◽  
Wei Ge ◽  
Liping Zhong ◽  
Yong Huang ◽  
...  

3D boron dipyrromethene (BODIPY)–Fe(iii) coordination polymer nanoparticles with NIR-II absorption were developed as photothermal and chemodynamic agent to effectively kill cancer cells.


Author(s):  
Filip J. Bodera ◽  
Michael J. Moore ◽  
Yanjie Wang ◽  
Al Christopher De Leon ◽  
Eric Abenojar ◽  
...  

2010 ◽  
Author(s):  
Katheryne Wilson ◽  
Kimberly Homan ◽  
Stanislav Emelianov

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