scholarly journals Quantitative ultrasound backscatter for pulsed cavitational ultrasound therapy-histotripsy

2009 ◽  
Vol 56 (5) ◽  
pp. 995-1005 ◽  
Author(s):  
T.-y. Wang ◽  
Zhen Xu ◽  
F. Winterroth ◽  
T.L. Hall ◽  
J.B. Fowlkes ◽  
...  
Keyword(s):  
Quantitative Ultrasound ◽  
Ultrasound Therapy ◽  
Ultrasound Backscatter

WE-EF-210-05: Diagnosis and Quantification of Liver Steatosis with Quantitative Ultrasound Backscatter Technique

2015 ◽  
Vol 42 (6Part39) ◽  
pp. 3684-3684
Author(s):  
M Andre ◽  
E Heba ◽  
A Han ◽  
S Lin ◽  
T Wolfson ◽  
...  
Keyword(s):  
Quantitative Ultrasound ◽  
Liver Steatosis ◽  
Ultrasound Backscatter

scholarly journals Quantitative Ultrasound Characterization of Tumor Cell Death: Ultrasound-Stimulated Microbubbles for Radiation Enhancement

2021 ◽  
Author(s):  
Raffi Karshafian ◽  
Hyunjung Christina Kim ◽  
Azza Al-Mahrouki ◽  
Alborz Gorjizadeh ◽  
Ali Sadeghi-Naini ◽  
...  
Keyword(s):  
Cell Death ◽  
Quantitative Ultrasound ◽  
Radiation Effects ◽  
Severe Combined Immunodeficiency ◽  
Cyclophilin A ◽  
Tumor Cell Death ◽  
Backscatter Intensity ◽  
Non Invasive ◽  
Cancer Cell Death ◽  
Ultrasound Backscatter

The aim of this study was to assess the efficacy of quantitative ultrasound imaging in characterizing cancer cell death caused by enhanced radiation treatments. This investigation focused on developing this ultrasound modality as an imaging-based non-invasive method that can be used to monitor therapeutic ultrasound and radiation effects. High-frequency (25 MHz) ultrasound was used to image tumor responses caused by ultrasound-stimulated microbubbles in combination with radiation. Human prostate xenografts grown in severe combined immunodeficiency (SCID) mice were treated using 8, 80, or 1000 µL/kg of microbubbles stimulated with ultrasound at 250, 570, or 750 kPa, and exposed to 0, 2, or 8 Gy of radiation. Tumors were imaged prior to treatment and 24 hours after treatment. Spectral analysis of images acquired from treated tumors revealed overall increases in ultrasound backscatter intensity and the spectral intercept parameter. The increase in backscatter intensity compared to the control ranged from 1.9±1.6 dB for the clinical imaging dose of microbubbles (8 µL/kg, 250 kPa, 2 Gy) to 7.0±4.1 dB for the most extreme treatment condition (1000 µL/kg, 750 kPa, 8 Gy). In parallel, in situ end-labelling (ISEL) staining, ceramide, and cyclophilin A staining demonstrated increases in cell death due to DNA fragmentation, ceramide-mediated apoptosis, and release of cyclophilin A as a result of cell membrane permeabilization, respectively. Quantitative ultrasound results indicated changes that paralleled increases in cell death observed from histology analyses supporting its use for non-invasive monitoring of cancer treatment outcomes.

scholarly journals Estimation of polydispersity in aggregating red blood cells by quantitative ultrasound backscatter analysis

2018 ◽  
Vol 143 (4) ◽  
pp. 2207-2216 ◽  
Author(s):  
Romain de Monchy ◽  
Julien Rouyer ◽  
François Destrempes ◽  
Boris Chayer ◽  
Guy Cloutier ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Quantitative Ultrasound ◽  
Blood Cells ◽  
Ultrasound Backscatter

Three‐dimensional detection of metastases in freshly excised human lymph nodes using quantitative ultrasound backscatter and envelope parameters.

2011 ◽  
Vol 129 (4) ◽  
pp. 2610-2610 ◽  
Author(s):  
Jonathan Mamou ◽  
Alain Coron ◽  
Emi Saegusa‐Beecroft ◽  
Masaki Hata ◽  
Michael L. Oelze ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Quantitative Ultrasound ◽  
Three Dimensional ◽  
Ultrasound Backscatter

scholarly journals OP02.01: Quantitative ultrasound backscatter parameters in the human cervix

2014 ◽  
Vol 44 (S1) ◽  
pp. 65-65
Author(s):  
Q.W. Guerrero ◽  
L. Carlsen ◽  
H. Feltovich ◽  
T.J. Hall
Keyword(s):  
Quantitative Ultrasound ◽  
Ultrasound Backscatter ◽  
Human Cervix

scholarly journals Quantitative Ultrasound Characterization of Tumor Cell Death: Ultrasound-Stimulated Microbubbles for Radiation Enhancement

2021 ◽  
Author(s):  
Raffi Karshafian ◽  
Hyunjung Christina Kim ◽  
Azza Al-Mahrouki ◽  
Alborz Gorjizadeh ◽  
Ali Sadeghi-Naini ◽  
...  
Keyword(s):  
Cell Death ◽  
Quantitative Ultrasound ◽  
Radiation Effects ◽  
Severe Combined Immunodeficiency ◽  
Cyclophilin A ◽  
Tumor Cell Death ◽  
Backscatter Intensity ◽  
Non Invasive ◽  
Cancer Cell Death ◽  
Ultrasound Backscatter

The aim of this study was to assess the efficacy of quantitative ultrasound imaging in characterizing cancer cell death caused by enhanced radiation treatments. This investigation focused on developing this ultrasound modality as an imaging-based non-invasive method that can be used to monitor therapeutic ultrasound and radiation effects. High-frequency (25 MHz) ultrasound was used to image tumor responses caused by ultrasound-stimulated microbubbles in combination with radiation. Human prostate xenografts grown in severe combined immunodeficiency (SCID) mice were treated using 8, 80, or 1000 µL/kg of microbubbles stimulated with ultrasound at 250, 570, or 750 kPa, and exposed to 0, 2, or 8 Gy of radiation. Tumors were imaged prior to treatment and 24 hours after treatment. Spectral analysis of images acquired from treated tumors revealed overall increases in ultrasound backscatter intensity and the spectral intercept parameter. The increase in backscatter intensity compared to the control ranged from 1.9±1.6 dB for the clinical imaging dose of microbubbles (8 µL/kg, 250 kPa, 2 Gy) to 7.0±4.1 dB for the most extreme treatment condition (1000 µL/kg, 750 kPa, 8 Gy). In parallel, in situ end-labelling (ISEL) staining, ceramide, and cyclophilin A staining demonstrated increases in cell death due to DNA fragmentation, ceramide-mediated apoptosis, and release of cyclophilin A as a result of cell membrane permeabilization, respectively. Quantitative ultrasound results indicated changes that paralleled increases in cell death observed from histology analyses supporting its use for non-invasive monitoring of cancer treatment outcomes.

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