Antidepressant-Like Effect of Low-Intensity Transcranial Ultrasound Stimulation

2019 ◽  
Vol 66 (2) ◽  
pp. 411-420 ◽  
Author(s):  
Daqu Zhang ◽  
Hangdao Li ◽  
Junfeng Sun ◽  
Weiwei Hu ◽  
Wen Jin ◽  
...  
Keyword(s):  
Transcranial Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation

scholarly journals Neuromodulation Effect of Very Low Intensity Transcranial Ultrasound Stimulation on Multiple Nuclei in Rat Brain

2021 ◽  
Vol 13 ◽  
Author(s):  
Yingjian Liu ◽  
Gang Wang ◽  
Chao Cao ◽  
Gaorui Zhang ◽  
Emily B. Tanzi ◽  
...  
Keyword(s):  
Field Potential ◽  
High Amplitude ◽  
Transcranial Ultrasound ◽  
Spectrum Estimation ◽  
Rhythmic Pattern ◽  
Neural Oscillation ◽  
Time Frequency ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
High Gamma

ObjectiveLow-intensity transcranial ultrasound stimulation (TUS) is a non-invasive neuromodulation technique with high spatial resolution and feasible penetration depth. To date, the mechanisms of TUS modulated neural oscillations are not fully understood. This study designed a very low acoustic intensity (AI) TUS system that produces considerably reduced AI Ultrasound pulses (ISPTA < 0.5 W/cm2) when compared to previous methods used to measure regional neural oscillation patterns under different TUS parameters.MethodsWe recorded the local field potential (LFP) of five brain nuclei under TUS with three groups of simulating parameters. Spectrum estimation, time-frequency analysis (TFA), and relative power analysis methods have been applied to investigate neural oscillation patterns under different stimulation parameters.ResultsUnder PRF, 500 Hz and 1 kHz TUS, high-amplitude LFP activity with the auto-rhythmic pattern appeared in selected nuclei when ISPTA exceeded 12 mW/cm2. With TFA, high-frequency energy (slow gamma and high gamma) was significantly increased during the auto-rhythmic patterns. We observed an initial plateau in nuclei response when ISPTA reached 16.4 mW/cm2 for RPF 500 Hz and 20.8 mW/cm2 for RPF 1 kHz. The number of responding nuclei started decreasing while ISPTA continued increasing. Under 1.5 kHz TUS, no auto-rhythmic patterns have been observed, but slow frequency power was increased during TUS. TUS inhibited most of the frequency band and generated obvious slow waves (theta and delta band) when stimulated at RPF = 1.5 kHz, ISPTA = 8.8 mW/cm2.ConclusionThese results demonstrate that very low intensity Transcranial Ultrasound Stimulation (VLTUS) exerts significant neuromodulator effects under specific parameters in rat models and may be a valid tool to study neuronal physiology.

scholarly journals Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review

2021 ◽  
Vol 15 ◽  
Author(s):  
Taewon Kim ◽  
Christine Park ◽  
Pratik Y. Chhatbar ◽  
Jody Feld ◽  
Brian Mac Grory ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Studies ◽  
Assessment Tool ◽  
Motor Behavior ◽  
Human Subjects ◽  
Human Studies ◽  
Transcranial Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation

Background: Although low-intensity transcranial ultrasound stimulation (LI-TUS) has received more recognition for its neuromodulation potential, there remains a crucial knowledge gap regarding the neuromodulatory effects of LI-TUS and its potential for translation as a therapeutic tool in humans.Objective: In this review, we summarized the findings reported by recently published studies regarding the effect of LI-TUS on neuromodulation in both animals and humans. We also aim to identify challenges and opportunities for the translation process.Methods: A literature search of PubMed, Medline, EMBASE, and Web of Science was performed from January 2019 to June 2020 with the following keywords and Boolean operators: [transcranial ultrasound OR transcranial focused ultrasound OR ultrasound stimulation] AND [neuromodulation]. The methodological quality of the animal studies was assessed by the SYRCLE's risk of bias tool, and the quality of human studies was evaluated by the PEDro score and the NIH quality assessment tool.Results: After applying the inclusion and exclusion criteria, a total of 26 manuscripts (24 animal studies and two human studies) out of 508 reports were included in this systematic review. Although both inhibitory (10 studies) and excitatory (16 studies) effects of LI-TUS were observed in animal studies, only inhibitory effects have been reported in primates (five studies) and human subjects (two studies). The ultrasonic parameters used in animal and human studies are different. The SYRCLE quality score ranged from 25 to 43%, with a majority of the low scores related to performance and detection bias. The two human studies received high PEDro scores (9/10).Conclusion: LI-TUS appears to be capable of targeting both superficial and deep cerebral structures to modulate cognitive or motor behavior in both animals and humans. Further human studies are needed to more precisely define the effective modulation parameters and thereby translate this brain modulatory tool into the clinic.

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