In Vivo Inflammatory and Wound Healing Effects of Gold Electrode Voltammetry for MEMS Micro-Reservoir Drug Delivery Device

2004 ◽  
Vol 51 (4) ◽  
pp. 627-635 ◽  
Author(s):  
G. Voskerician ◽  
R.S. Shawgo ◽  
P.A. Hiltner ◽  
J.M. Anderson ◽  
M.J. Cima ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Gold Electrode ◽  
Delivery Device ◽  
Drug Delivery Device

In vivo tolerance and kinetics of a novel ocular drug delivery device

2006 ◽  
Vol 116 (2) ◽  
pp. e47-e49 ◽  
Author(s):  
R.T. Pijls ◽  
H.H.L. Hanssen ◽  
R.M.M.A. Nuijts ◽  
G.W. Daube ◽  
L.H. Koole
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Kinetics Of

In Vitro–In Vivo Evaluation of an Oral Ghost Drug Delivery Device for the Delivery of Salmon Calcitonin

2018 ◽  
Vol 107 (6) ◽  
pp. 1605-1614 ◽  
Author(s):  
Angus R. Hibbins ◽  
Mershen Govender ◽  
Sunaina Indermun ◽  
Pradeep Kumar ◽  
Lisa C. du Toit ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Salmon Calcitonin ◽  
Delivery Device ◽  
In Vivo Evaluation ◽  
Drug Delivery Device

scholarly journals Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures

2021 ◽  
Vol 7 (1) ◽  
pp. eabd4639
Author(s):  
Hyunwoo Joo ◽  
Youngsik Lee ◽  
Jaemin Kim ◽  
Jeong-Suk Yoo ◽  
Seungwon Yoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Survival Rates ◽  
Animal Experiments ◽  
Wearable Devices ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Novel Treatment ◽  
Medical Emergencies

Personalized biomedical devices have enormous potential to solve clinical challenges in urgent medical situations. Despite this potential, a device for in situ treatment of fatal seizures using pharmaceutical methods has not been developed yet. Here, we present a novel treatment system for neurological medical emergencies, such as status epilepticus, a fatal epileptic condition that requires immediate treatment, using a soft implantable drug delivery device (SID). The SID is integrated wirelessly with wearable devices for monitoring electroencephalography signals and triggering subcutaneous drug release through wireless voltage induction. Because of the wireless integration, bulky rigid components such as sensors, batteries, and electronic circuits can be moved from the SID to wearables, and thus, the mechanical softness and miniaturization of the SID are achieved. The efficacy of the prompt treatment could be demonstrated with animal experiments in vivo, in which brain damages were reduced and survival rates were increased.

Magnetically-actuated drug delivery device (MADDD) for minimally invasive treatment of prostate cancer: An in vivo animal pilot study

The Prostate ◽  
2017 ◽  
Vol 77 (13) ◽  
pp. 1356-1365 ◽  
Author(s):  
Werner J. Struss ◽  
Zheng Tan ◽  
Payam Zachkani ◽  
Igor Moskalev ◽  
John K. Jackson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Pilot Study ◽  
Minimally Invasive ◽  
Minimally Invasive Treatment ◽  
Delivery Device ◽  
Invasive Treatment ◽  
Drug Delivery Device ◽  
Magnetically Actuated

An in-vivo evaluation of a MEMS drug delivery device using Kunming mice model

2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Yaqian Liu ◽  
Peiyi Song ◽  
Jianwei Liu ◽  
Danny Jian Hang Tng ◽  
Rui Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mice Model ◽  
Delivery Device ◽  
In Vivo Evaluation ◽  
Drug Delivery Device

scholarly journals Therapeutic effects of EGF-modified curcumin/chitosan nano-spray on wound healing

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Yue Li ◽  
QingQing Leng ◽  
XianLun Pang ◽  
Huan Shi ◽  
YanLin Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Chitosan Nanoparticles ◽  
Skin Lesions ◽  
In Vitro Assays ◽  
Therapeutic Effects ◽  
Skin Defects ◽  
Post Operation

Abstract Dermal injury, including trauma, surgical incisions, and burns, remain the most prevalent socio-economical health care issue in the clinic. Nanomedicine represents a reliable administration strategy that can promote the healing of skin lesions, but the lack of effective drug delivery methods can limit its effectiveness. In this study, we developed a novel nano-drug delivery system to treat skin defects through spraying. We prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor (EGF) to develop an aqueous EGF-modified spray (EGF@CCN) for the treatment of dermal wounds. In vitro assays showed that the EGF@CCN displayed low cytotoxicity, and that curcumin was continuously and slowly released from the EGF@CCN. In vivo efficacy on wound healing was then evaluated using full-thickness dermal defect models in Wistar rats, showing that the EGF@CCN had significant advantages in promoting wound healing. On day 12 post-operation, skin defects in the rats of the EGF@CCN group were almost completely restored. These effects were related to the activity of curcumin and EGF on skin healing, and the high compatibility of the nano formulation. We therefore conclude that the prepared nano-scaled EGF@CCN spray represents a promising strategy for the treatment of dermal wounds.

scholarly journals Novel Drug Delivery Device Using Silicone: Controlled Release of Insoluble Drugs or Two Kinds of Water-Soluble Drugs

2003 ◽  
Vol 51 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Masako Kajihara ◽  
Toshihiko Sugie ◽  
Hiroo Maeda ◽  
Akihiko Sano ◽  
Keiji Fujioka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Water Soluble ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Water Soluble Drugs ◽  
Insoluble Drugs ◽  
Novel Drug
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